Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Vaccinia Viruses As Vectors For Vaccine Antigens PDF full book. Access full book title Vaccinia Viruses As Vectors For Vaccine Antigens.
| Author | : Gerald V. Quinnan |
| Publisher | : Elsevier Publishing Company |
| Total Pages | : 280 |
| Release | : 1985 |
| Genre | : Medical |
| ISBN | : |
| Author | : Gerald V. Quinnan |
| Publisher | : |
| Total Pages | : 258 |
| Release | : 1985 |
| Genre | : Smallpox |
| ISBN | : |
| Author | : Stuart N. Isaacs |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 402 |
| Release | : 2008-02-03 |
| Genre | : Science |
| ISBN | : 1592597890 |
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
| Author | : Sara Cohen |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 197 |
| Release | : 2013-06-29 |
| Genre | : Medical |
| ISBN | : 1489913823 |
Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).
| Author | : Thiru Vanniasinkam |
| Publisher | : Springer Nature |
| Total Pages | : 232 |
| Release | : 2020-11-30 |
| Genre | : Medical |
| ISBN | : 3030519279 |
This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology.
| Author | : Fred Brown |
| Publisher | : S. Karger AG (Switzerland) |
| Total Pages | : 284 |
| Release | : 1994 |
| Genre | : Medical |
| ISBN | : |
This volume explores the use of recombinant vectors in the development of new vaccines to benefit both human and animal health. Emphasis is placed on bacterial and viral vectors and their applications.
| Author | : Stanley A. Plotkin |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 1748 |
| Release | : 2008-02-11 |
| Genre | : Medical |
| ISBN | : 1437721583 |
Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination-from development to use in reducing disease. It provides authoritative information on vaccine production, available preparations, efficacy, and safety...recommendations for vaccine use, with rationales...data on the impact of vaccination programs on morbidity and mortality...and more. And now, as an Expert Consult title, it includes a companion web site offering this unparalleled guidance where and when you need it most! Provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well an epidemiology and public health issues. Offers comprehensive coverage of both existing vaccines and vaccines currently in the research and development stage. Examines vaccine stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease control strategies. Analyses the cost-benefit and cost-effectiveness of vaccines. Discusses the proper use of immune globulins and antitoxins. Illustrates concepts and objective data with approximately 600 tables and figures. Includes access to a companion web site offering the complete contents of the book - fully searchable - for rapid consultation from anyplace with an Internet connection.
| Author | : Igor S Lukashevich |
| Publisher | : Springer |
| Total Pages | : 393 |
| Release | : 2014-11-13 |
| Genre | : Medical |
| ISBN | : 3709118182 |
This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.
| Author | : Alice Marie Bennett |
| Publisher | : |
| Total Pages | : 283 |
| Release | : 1995 |
| Genre | : |
| ISBN | : |
| Author | : Allan Granoff |
| Publisher | : Academic Press |
| Total Pages | : 926 |
| Release | : 1999-09-03 |
| Genre | : Medical |
| ISBN | : |
Reference source of current virological knowledge. It is also the first to bring together all aspects of the subject for a wide variety of readers. Unique in its use of concise 'mini-review' articles, the mate rial covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria, and insects. More general articles focus on the effects of viruses on the immune system, the role of viruses in disease, oncology, gene therapy, and evolution, plus a wide range of related topics.
