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Using Ontology and Semantic Web Services to Support Modeling in Systems Biology

Using Ontology and Semantic Web Services to Support Modeling in Systems Biology
Author: Z. Sun
Publisher:
Total Pages:
Release: 2009
Genre:
ISBN:

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This thesis addresses the problem of collaboration among experimental biologists and modelers in the study of systems biology by using ontology and Semantic Web Services techniques. Modeling in systems biology is concerned with using experimental information and mathematical methods to build quantitative models across different biological scales. This requires interoperation among various knowledge sources and services. Ontology and Semantic Web Services potentially provide an infrastructure to meet this requirement. In our study, we propose an ontology-centered framework within the Semantic Web infrastructure that aims at standardizing various areas of knowledge involved in the biological modeling processes. In this framework, first we specify an ontology-based meta-model for building biological models. This meta-model supports using shared biological ontologies to annotate biological entities in the models, allows semantic queries and automatic discoveries, enables easy model reuse and composition, and serves as a basis to embed external knowledge. We also develop means of transforming biological data sources and data analysis methods into Web Services. These Web Services can then be composed together to perform parameterization in biological modeling. The knowledge of decision-making and workflow of parameterization processes are then recorded by the semantic descriptions of these Web Services, and embedded in model instances built on our proposed meta-model. We use three cases of biological modeling to evaluate our framework. By examining our ontology-centered framework in practice, we conclude that by using ontology to represent biological models and using Semantic Web Services to standardize knowledge components in modeling processes, greater capabilities of knowledge sharing, reuse and collaboration can be achieved. We also conclude that ontology-based biological models with formal semantics are essential to standardize knowledge in compliance with the Semantic Web vision.


Ontology-Based Applications for Enterprise Systems and Knowledge Management

Ontology-Based Applications for Enterprise Systems and Knowledge Management
Author: Nazir Ahmad, Mohammad
Publisher: IGI Global
Total Pages: 429
Release: 2012-08-31
Genre: Computers
ISBN: 1466619945

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"This book provides an opportunity for readers to clearly understand the notion of ontology engineering and the practical aspects of this approach in the domains of two interest areas: Knowledge Management Systems and Enterprise Systems"--


Web Information Systems Engineering – WISE 2007 Workshops

Web Information Systems Engineering – WISE 2007 Workshops
Author: Mathias Weske
Publisher: Springer
Total Pages: 526
Release: 2007-11-22
Genre: Computers
ISBN: 3540770100

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This book constitutes the joint refereed proceedings of six workshops held in conjunction with the 8th International Conference on Web Information Systems Engineering, WISE 2007 in Nancy, France, in December 2007. The 44 revised full papers presented were carefully reviewed and selected from numerous submissions for presentation in the six workshops. The workshops discuss a broad range of subjects.


Semantic Web

Semantic Web
Author: Christopher J. O. Baker
Publisher: Springer Science & Business Media
Total Pages: 449
Release: 2007-04-14
Genre: Science
ISBN: 0387484388

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This book introduces advanced semantic web technologies, illustrating their utility and highlighting their implementation in biological, medical, and clinical scenarios. It covers topics ranging from database, ontology, and visualization to semantic web services and workflows. The volume also details the factors impacting on the establishment of the semantic web in life science and the legal challenges that will impact on its proliferation.


Semantic Web Services, Processes and Applications

Semantic Web Services, Processes and Applications
Author: Jorge Cardoso
Publisher: Springer Science & Business Media
Total Pages: 400
Release: 2006-12-26
Genre: Computers
ISBN: 0387346856

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Semantics, Web services, and Web processes promise better re-use, universal interoperability and integration. Semantics has been recognized as the primary tool to address the challenges of a broad spectrum of heterogeneity and for improving automation through machine understandable descriptions. Semantic Web Services, Processes and Applications brings contributions from researchers who study, explore and understand the semantic enabling of all phases of semantic Web processes. This encompasses design, annotation, discovery, choreography and composition. Also this book presents fundamental capabilities and techniques associated with ontological modeling or services, annotation, matching and mapping, and reasoning. This is complemented by discussion of applications in e-Government and bioinformatics. Special bulk rates are available for course adoption through Publishing Editor.


Bioinformatics

Bioinformatics
Author: Information Resources Management Association
Publisher: IGI Global
Total Pages: 1826
Release: 2013-03-31
Genre: Computers
ISBN: 146663605X

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"Bioinformatics: Concepts, Methodologies, Tools, and Applications highlights the area of bioinformatics and its impact over the medical community with its innovations that change how we recognize and care for illnesses"--Provided by publisher.


The Semantic Web

The Semantic Web
Author: Vipul Kashyap
Publisher: Springer Science & Business Media
Total Pages: 415
Release: 2008-08-15
Genre: Computers
ISBN: 3540764518

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The Semantic Web is a vision – the idea of having data on the Web defined and linked in such a way that it can be used by machines not just for display purposes but for automation, integration and reuse of data across various applications. However, there is a widespread misconception that the Semantic Web is a rehash of existing AI and database work. Kashyap, Bussler, and Moran dispel this notion by presenting the multi-disciplinary technological underpinnings such as machine learning, information retrieval, service-oriented architectures, and grid computing. Thus they combine the informational and computational aspects needed to realize the full potential of the Semantic Web vision.


Intelligent Computing in Bioinformatics

Intelligent Computing in Bioinformatics
Author: De-Shuang Huang
Publisher: Springer
Total Pages: 532
Release: 2014-07-03
Genre: Computers
ISBN: 3319093304

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This book – in conjunction with the volumes LNCS 8588 and LNAI 8589 – constitutes the refereed proceedings of the 10th International Conference on Intelligent Computing, ICIC 2014, held in Taiyuan, China, in August 2014. The 58 papers of this volume were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections such as machine learning; neural networks; image processing; computational systems biology and medical informatics; biomedical informatics theory and methods; advances on bio-inspired computing; protein and gene bioinformatics: analysis, algorithms, applications.


Semantic Web Technologies

Semantic Web Technologies
Author: John Davies
Publisher: John Wiley & Sons
Total Pages: 326
Release: 2006-05-01
Genre: Technology & Engineering
ISBN: 0470030348

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The Semantic Web combines the descriptive languages RDF (Resource Description Framework) and OWL (Web Ontology Language), with the data-centric, customizable XML (eXtensible Mark-up Language) to provide descriptions of the content of Web documents. These machine-interpretable descriptions allow more intelligent software systems to be written, automating the analysis and exploitation of web-based information. Software agents will be able to create automatically new services from already published services, with potentially huge implications for models of e-Business. Semantic Web Technologies provides a comprehensive overview of key semantic knowledge technologies and research. The authors explain (semi-)automatic ontology generation and metadata extraction in depth, along with ontology management and mediation. Further chapters examine how Semantic Web technology is being applied in knowledge management (“Semantic Information Access”) and in the next generation of Web services. Semantic Web Technologies: Provides a comprehensive exposition of the state-of-the art in Semantic Web research and key technologies. Explains the use of ontologies and metadata to achieve machine-interpretability. Describes methods for ontology learning and metadata generation. Discusses ontology management and evolution, covering ontology change detection and propagation, ontology dependency and mediation. Illustrates the theoretical concepts with three case studies on industrial applications in digital libraries, the legal sector and the telecommunication industry. Graduate and advanced undergraduate students, academic and industrial researchers in the field will all find Semantic Web Technologies an essential guide to the technologies of the Semantic Web.