Understanding The Crosstalk Between Immune Cells And The Tumor Microenvironment In Cancer And Its Implications For Immunotherapy PDF Download
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| Author | : Noha Mousaad Elemam |
| Publisher | : Frontiers Media SA |
| Total Pages | : 144 |
| Release | : 2023-09-13 |
| Genre | : Medical |
| ISBN | : 2832534929 |
Download Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy Book in PDF, ePub and Kindle
One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.
| Author | : Bo Kong |
| Publisher | : Frontiers Media SA |
| Total Pages | : 167 |
| Release | : 2023-08-31 |
| Genre | : Science |
| ISBN | : 2832532705 |
Download Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: An emerging target of anti-cancer immunotherapy Book in PDF, ePub and Kindle
| Author | : Muzafar Ahmad Macha |
| Publisher | : Springer Nature |
| Total Pages | : 223 |
| Release | : 2022-05-16 |
| Genre | : Medical |
| ISBN | : 9811662266 |
Download Immuno-Oncology Crosstalk and Metabolism Book in PDF, ePub and Kindle
This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
| Author | : Yongsheng Li |
| Publisher | : Frontiers Media SA |
| Total Pages | : 87 |
| Release | : 2019-03-20 |
| Genre | : |
| ISBN | : 2889457850 |
Download Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment Book in PDF, ePub and Kindle
Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.
| Author | : Peter P. Lee |
| Publisher | : Springer Nature |
| Total Pages | : 326 |
| Release | : 2020-03-25 |
| Genre | : Medical |
| ISBN | : 303038862X |
Download Tumor Microenvironment Book in PDF, ePub and Kindle
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
| Author | : Haidong Dong |
| Publisher | : Springer |
| Total Pages | : 164 |
| Release | : 2018-01-05 |
| Genre | : Medical |
| ISBN | : 3319706225 |
Download The Basics of Cancer Immunotherapy Book in PDF, ePub and Kindle
This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today’s daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors’ expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.
| Author | : Michael R Shurin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 745 |
| Release | : 2013-03-19 |
| Genre | : Medical |
| ISBN | : 9400762178 |
Download The Tumor Immunoenvironment Book in PDF, ePub and Kindle
Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
| Author | : Magdalena Klink |
| Publisher | : Springer Nature |
| Total Pages | : 358 |
| Release | : 2022-02-14 |
| Genre | : Medical |
| ISBN | : 3030913112 |
Download Interaction of Immune and Cancer Cells Book in PDF, ePub and Kindle
Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.
| Author | : Haidong Dong |
| Publisher | : Springer Nature |
| Total Pages | : 228 |
| Release | : |
| Genre | : |
| ISBN | : 3031594754 |
Download The Basics of Cancer Immunotherapy Book in PDF, ePub and Kindle
| Author | : Petranel T. Ferrao |
| Publisher | : Frontiers Media SA |
| Total Pages | : 186 |
| Release | : 2019-11-01 |
| Genre | : |
| ISBN | : 288963115X |
Download Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response Book in PDF, ePub and Kindle
Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.
