Umbilical Cord Blood Cells For Perinatal Brain Injury The Right Cells At The Right Time PDF Download
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| Author | : Courtney A. McDonald |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : Science |
| ISBN | : |
Download Umbilical Cord Blood Cells for Perinatal Brain Injury: The Right Cells at the Right Time? Book in PDF, ePub and Kindle
Cerebral palsy (CP) is the most common cause of physical disability in children. CP currently has no cure and there are only few interventions to prevent the development of disability. There are four principal complications of pregnancy or birth that can damage the developing brain and lead to CP: preterm birth, fetal growth restriction, infection during pregnancy and severe hypoxia-ischemia at birth. Umbilical cord blood (UCB) cells are a very promising therapy for the treatment of CP. While UCB therapy for juveniles with CP is currently being assessed in clinical trials, very little is known about their mechanisms of action or which cells found in umbilical cord blood protect against and/or repair brain injury. In this chapter, we first explore the complications that can lead to perinatal brain injury. We then discuss the different cell types found in UCB and the specific properties that make each of them individually attractive therapeutic candidates for treatment of perinatal brain injury. While UCB holds much promise as a therapy for CP, it is imperative that more research is conducted to understand how the different cell types found in UCB can protect against brain injury in order to design more effective and targeted therapies.
| Author | : Haruo Shintaku |
| Publisher | : Springer |
| Total Pages | : 155 |
| Release | : 2018-03-01 |
| Genre | : Medical |
| ISBN | : 9811014124 |
Download Cell Therapy for Perinatal Brain Injury Book in PDF, ePub and Kindle
This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.
| Author | : Sandra Kumbruch |
| Publisher | : |
| Total Pages | : |
| Release | : 2008 |
| Genre | : |
| ISBN | : |
Download Mechanisms of Therapeutic Effects of Umbilical Cord Blood Cells After Perinatal Hypoxic-ischemic Brain Damage in the Rat Book in PDF, ePub and Kindle
| Author | : Ana Colette Maurício |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 260 |
| Release | : 2017-01-11 |
| Genre | : Science |
| ISBN | : 9535128655 |
Download Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine Book in PDF, ePub and Kindle
Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.
| Author | : Anthony Atala |
| Publisher | : Academic Press |
| Total Pages | : 438 |
| Release | : 2018-06-14 |
| Genre | : Medical |
| ISBN | : 0128120630 |
Download Perinatal Stem Cells Book in PDF, ePub and Kindle
Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells
| Author | : Mari Dezawa |
| Publisher | : Springer |
| Total Pages | : 315 |
| Release | : 2018-11-27 |
| Genre | : Medical |
| ISBN | : 4431568476 |
Download Muse Cells Book in PDF, ePub and Kindle
This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.
| Author | : Marc Fisher |
| Publisher | : Butterworth-Heinemann |
| Total Pages | : 432 |
| Release | : 2001 |
| Genre | : Medical |
| ISBN | : |
Download Stroke Therapy Book in PDF, ePub and Kindle
This new edition keeps you up to date with the exciting new developments in treating cerebrovascular disorders. Comprehensive and practical, it surveys methods for accurate stroke diagnosis necessary for you to make appropriate therapeutic decisions.
| Author | : Bernhard Schaller |
| Publisher | : Nova Publishers |
| Total Pages | : 116 |
| Release | : 2008 |
| Genre | : Cerebral anoxia |
| ISBN | : 9781604562286 |
Download Endogenous Neuroprotection Book in PDF, ePub and Kindle
Endogenous neuoprotection is a phenomenon where a brief episode of ischemia renders the brain resistant against a subsequent longer-asting ischemia event. Experimentally, the author was able to model hypoxic preconditioning in animal model. Increasing knowledge of this endogenous neuroprotectin by ischemic tolerance may help to minimize neuronal damage following ischemic stroke and hypoxic encephalopathy. This book is, therefore, the first overview of this important topic and will certainly influence further investigations in clinical and neuroscience research.
| Author | : Pedro A. de Alarcón |
| Publisher | : Cambridge University Press |
| Total Pages | : 501 |
| Release | : 2021-02-18 |
| Genre | : Medical |
| ISBN | : 1108488986 |
Download Neonatal Hematology Book in PDF, ePub and Kindle
An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.
| Author | : Raymond W. Redline |
| Publisher | : Cambridge University Press |
| Total Pages | : 367 |
| Release | : 2018-08-23 |
| Genre | : Medical |
| ISBN | : 1316632539 |
Download Placental and Gestational Pathology with Online Resource Book in PDF, ePub and Kindle
A guide to identifying disease processes in the placenta affecting pregnancy outcome, with current diagnostic criteria and clinical consequences.
