Trial at Arms
Author | : Ian Bisset |
Publisher | : |
Total Pages | : 159 |
Release | : 1960 |
Genre | : |
ISBN | : |
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Author | : Ian Bisset |
Publisher | : |
Total Pages | : 159 |
Release | : 1960 |
Genre | : |
ISBN | : |
Author | : Massachusetts Arms Company |
Publisher | : |
Total Pages | : 418 |
Release | : 1851 |
Genre | : |
ISBN | : |
Author | : |
Publisher | : |
Total Pages | : 215 |
Release | : 1957 |
Genre | : |
ISBN | : |
Author | : Massachusetts Arms Company |
Publisher | : Legare Street Press |
Total Pages | : 0 |
Release | : 2022-10-27 |
Genre | : History |
ISBN | : 9781018190716 |
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author | : United States. War Department |
Publisher | : |
Total Pages | : 176 |
Release | : 1856 |
Genre | : |
ISBN | : |
Author | : Ying Yuan |
Publisher | : CRC Press |
Total Pages | : 238 |
Release | : 2017-12-19 |
Genre | : Mathematics |
ISBN | : 1315354225 |
Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.
Author | : Ian Bisset |
Publisher | : |
Total Pages | : 232 |
Release | : 1957 |
Genre | : Courts-martial and courts of inquiry |
ISBN | : |
Author | : Guosheng Yin |
Publisher | : John Wiley & Sons |
Total Pages | : 368 |
Release | : 2012-01-03 |
Genre | : Medical |
ISBN | : 0470581719 |
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Author | : [Anonymus AC10243174] |
Publisher | : |
Total Pages | : 176 |
Release | : 1856 |
Genre | : |
ISBN | : |
Author | : |
Publisher | : |
Total Pages | : |
Release | : 1957 |
Genre | : Courts-martial and courts of inquiry |
ISBN | : |