Translational Toxicology And Therapeutics PDF Download
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Author | : Claude L. Hughes |
Publisher | : Humana Press |
Total Pages | : 384 |
Release | : 2016-03-23 |
Genre | : Medical |
ISBN | : 331927449X |
Download Translational Toxicology Book in PDF, ePub and Kindle
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
Author | : Claude L. Hughes |
Publisher | : |
Total Pages | : |
Release | : 2018 |
Genre | : MEDICAL |
ISBN | : 9781119023647 |
Download Translational Toxicology and Therapeutics Book in PDF, ePub and Kindle
Author | : Michael D. Waters |
Publisher | : John Wiley & Sons |
Total Pages | : 790 |
Release | : 2018-01-04 |
Genre | : Medical |
ISBN | : 1119023602 |
Download Translational Toxicology and Therapeutics Book in PDF, ePub and Kindle
Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms
Author | : Michael D. Waters |
Publisher | : Royal Society of Chemistry |
Total Pages | : 595 |
Release | : 2022-04-27 |
Genre | : Medical |
ISBN | : 1839163062 |
Download The Coronavirus Pandemic and the Future: Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 1 Book in PDF, ePub and Kindle
By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.
Author | : Claude L. Hughes |
Publisher | : Royal Society of Chemistry |
Total Pages | : 695 |
Release | : 2022-04-27 |
Genre | : Medical |
ISBN | : 1839166789 |
Download The Coronavirus Pandemic and the Future: Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 2 Book in PDF, ePub and Kindle
This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to repurpose and produce new therapeutics and vaccines. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.
Author | : Joy A. Cavagnaro |
Publisher | : CRC Press |
Total Pages | : 542 |
Release | : 2021-11-26 |
Genre | : Medical |
ISBN | : 1000471829 |
Download Translational Medicine Book in PDF, ePub and Kindle
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Author | : Martin Wehling |
Publisher | : Academic Press |
Total Pages | : 365 |
Release | : 2015-04-02 |
Genre | : Science |
ISBN | : 0128007214 |
Download Principles of Translational Science in Medicine Book in PDF, ePub and Kindle
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions
Author | : Michael D. Waters |
Publisher | : John Wiley & Sons |
Total Pages | : 716 |
Release | : 2017-11-10 |
Genre | : Medical |
ISBN | : 1119023629 |
Download Translational Toxicology and Therapeutics Book in PDF, ePub and Kindle
Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms
Author | : Bertram G. Katzung |
Publisher | : |
Total Pages | : 1217 |
Release | : 2001 |
Genre | : Clinical pharmacology |
ISBN | : 9780071179683 |
Download Basic and Clinical Pharmacology Book in PDF, ePub and Kindle
This best selling book delivers the most current, complete, and authoritative pharmacology information to students and practitioners. All sections are updated with new drug information and references. New! Many new figures and diagrams, along with boxes of highlighted material explaining the "how and why" behind the facts.
Author | : Yvonne Will |
Publisher | : John Wiley & Sons |
Total Pages | : 899 |
Release | : 2016-03-22 |
Genre | : Medical |
ISBN | : 1119053390 |
Download Drug Discovery Toxicology Book in PDF, ePub and Kindle
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices