Translational Research Methods For Diabetes Obesity And Cardiometabolic Drug Development PDF Download
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Author | : Andrew J. Krentz |
Publisher | : Springer |
Total Pages | : 316 |
Release | : 2014-11-29 |
Genre | : Medical |
ISBN | : 1447149203 |
Download Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development Book in PDF, ePub and Kindle
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Author | : Andrew J. Krentz |
Publisher | : Springer |
Total Pages | : 556 |
Release | : 2019-04-02 |
Genre | : Medical |
ISBN | : 3030117480 |
Download Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease Book in PDF, ePub and Kindle
This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Author | : Dorairaj Prabhakaran |
Publisher | : World Bank Publications |
Total Pages | : 948 |
Release | : 2017-11-17 |
Genre | : Medical |
ISBN | : 1464805202 |
Download Disease Control Priorities, Third Edition (Volume 5) Book in PDF, ePub and Kindle
Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.
Author | : National Academies of Sciences Engineering and Medicine |
Publisher | : |
Total Pages | : |
Release | : 2021-12-02 |
Genre | : |
ISBN | : 9780309684736 |
Download High and Rising Mortality Rates Among Working-Age Adults Book in PDF, ePub and Kindle
Author | : Roger Detels |
Publisher | : Oxford University Press |
Total Pages | : 1717 |
Release | : 2017 |
Genre | : Medical |
ISBN | : 019881013X |
Download Oxford Textbook of Global Public Health Book in PDF, ePub and Kindle
Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline
Author | : Magdalene K. Montgomery |
Publisher | : Frontiers Media SA |
Total Pages | : 320 |
Release | : 2022-09-07 |
Genre | : Medical |
ISBN | : 2889769135 |
Download Non-Alcoholic Steatohepatitis (NASH) – Metabolic Contributors and Therapeutic Targets Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 94 |
Release | : 2002 |
Genre | : Obesity |
ISBN | : |
Download The Practical Guide Book in PDF, ePub and Kindle
Author | : Empar Lurbe |
Publisher | : Springer |
Total Pages | : 277 |
Release | : 2019-07-29 |
Genre | : Medical |
ISBN | : 3030181677 |
Download Hypertension in Children and Adolescents Book in PDF, ePub and Kindle
This book is devoted to hypertension in children and adolescents, a clinical issue that – thanks to the strides made in several areas of pathophysiological and clinical research – has received growing interest in cardiovascular medicine over the last several years. Given the increasing prevalence of hypertension in children and adolescents, this book represents an important and useful tool to address what has become a significant public health issue. It covers a diverse range of topics, from advances in the definition of hypertension and the identification of new risk factors, to current treatment strategies. The book also presents an overview of the latest findings, including the clinical significance of isolated systolic hypertension (ISH) in youth, the importance of out-of-office and central blood pressure measurement, new methods for assessing vascular phenotypes, and clustering of CV risk factors. Gathering contributions by international experts and pursuing a practice-oriented approach, the book offers a valuable tool for cardiologists, pediatricians and nephrologists, as well as general practitioners.
Author | : Dr Nikhil Dhurandhar |
Publisher | : HarperCollins |
Total Pages | : 240 |
Release | : 2018-01-10 |
Genre | : Health & Fitness |
ISBN | : 9352770315 |
Download Dr Dhurandhar's Fat-loss Diet Book in PDF, ePub and Kindle
Author | : Samy I. McFarlane |
Publisher | : Springer Science & Business Media |
Total Pages | : 196 |
Release | : 2012-10-19 |
Genre | : Medical |
ISBN | : 1603273573 |
Download Diabetes and Hypertension Book in PDF, ePub and Kindle
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.