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Biological Transformation

Biological Transformation
Author: Reimund Neugebauer
Publisher: Springer Nature
Total Pages: 404
Release: 2020-09-11
Genre: Technology & Engineering
ISBN: 3662596598
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The global population is expected to rise to 9.8 billion by the year 2050 - with everyone ultimately striving for prosperity. New methods must therefore be found to achieve more efficient production. Research to date shows that the biological inventory that has evolved: its products, processes, principles and tools, can spur modern technology. The development of technological innovations based on biological concepts, with the goal of particularly innovative and sustainable value creation, today is collectively known as "biological transformation". It results in highly functional products with striking properties that can be both manufactured and utilized in a resource-saving way. In terms of taking responsibility of the good of all people, biological transformation is therefore a path that applied research will have to take. The Fraunhofer-Gesellschaft has recognized the developmental technology potential of biological transformation and sees it as its task not only to drive the relevant research forward, but also to promote public awareness of the topic.

Systematic

Systematic
Author: James R. Valcourt
Publisher: Bloomsbury Publishing USA
Total Pages: 289
Release: 2017-02-07
Genre: Science
ISBN: 1632860317
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A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.

Transforming Biology

Transforming Biology
Author: Juliet Flesch
Publisher: Melbourne Univ. Publishing
Total Pages: 395
Release: 2015-04-01
Genre: Science
ISBN: 0522867715
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Transforming Biology opens a window on the lives and work of the scientists, teachers and students who have contributed to the achievements of the Department of Biochemistry and Molecular Biology at the University of Melbourne. Established in 1938, the department teaches and undertakes research in a discipline that links chemistry, physiology, genetics, microbiology, virology and physics, and has championed new techniques and biotechnology innovations that reverberate around the world. Highlighting the successful careers of many of its alumni and staff, including the influential Victor Trikojus, and the impact of benefactors such as Russell Grimwade, Juliet Flesch tells the story of the evolution of a department engaged in fundamental biomolecular science, as well as the translation of discoveries to industry and the clinic. It has been one of the most important national and international bodies engaged in transforming biology.

Nano Comes to Life

Nano Comes to Life
Author: Sonia Contera
Publisher: Princeton University Press
Total Pages: 232
Release: 2021-11-16
Genre: Medical
ISBN: 0691206449
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"Increasingly, scientists are gaining control over matter at the nanometer scale. Spearheaded by physical scientists operating at the interfaces of physics and biology (such as the author herself), advances in nanoscience and technology are transforming how we think about life and treat human health. This is due to a convergence of size. To do medicine, one must understand and be able to reach the nanoscale environment of healthy cells in tissues and organs, as well as other nano-sized building blocks that constitute a living organism, such as proteins and DNA. The ground-breaking advances being made at the frontiers of nanoscience and -technology, specifically in the areas of biology and medicine, are the subject of this short, popular-level book. Chapter 1 describes how nanotechnology and quantitative methods in biology are progressively being deployed to embrace life in all its multiscale, hierarchical intricacy and multiplicity. Chapters 2 through 4 review how bioinspired and biomimetic nanostructures and nanomachines are being created and integrated into strategies aimed at solving specific medical problems. In particular, Chapter 2 summarizes how scientists are seeking to build artificial nanostructures using both biological molecules and the organizational principles of biology. Chapter 3 gives an account of how nanotechnology is being used to develop drug-delivery strategies that specifically target cancer cells and tumors to improve the efficacy of current cancer chemotherapies. Chapter 4 reviews the science of one of the most potentially transformative scientific fields: tissue engineering. In a concluding chapter (Chapter 5), Contera reviews how nanotechnology, biology, and medicine will continue fusing with other sciences and technologies - incorporating more mathematical and computational modelling, as well as AI and robotics. Nanoscale devices will be used to learn biology; and biology will be used to inspire increasingly sophisticated "transmaterial" devices that mimic some of the characteristics of biology and incorporate new features that are not available in the biological world. The effects on human health and longevity will be profound. In a more personal epilogue, Contera describes the crossroads at which we find ourselves. Accessing our own biology evokes a mixture of possibility and dread. However, Contera maintains that we can create a positive transmaterial world for the benefit of humankind, and she describes ways in which scientists are proactively engaging with the public, politicians, industry, and entrepreneurs, as well as the media and the arts, to communicate the power and risks of new advances and to influence the ways in which new technologies will affect our future"--

Molecular Biology of The Cell

Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
Total Pages: 0
Release: 2002
Genre: Cytology
ISBN: 9780815332183
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Digital Biology

Digital Biology
Author: Peter J. Bentley
Publisher: Simon and Schuster
Total Pages: 407
Release: 2010-05-11
Genre: Computers
ISBN: 0743238168
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Imagine a future world where computers can create universes -- digital environments made from binary ones and zeros. Imagine that within these universes there exist biological forms that reproduce, grow, and think. Imagine plantlike forms, ant colonies, immune systems, and brains, all adapting, evolving, and getting better at solving problems. Imagine if our computers became greenhouses for a new kind of nature. Just think what digital biology could do for us. Perhaps it could evolve new designs for us, think up ways to detect fraud using digital neurons, or solve scheduling problems with ants. Perhaps it could detect hackers with immune systems or create music from the patterns of growth of digital seashells. Perhaps it would allow our computers to become creative and inventive. Now stop imagining. digital biology is an intriguing glimpse into the future of technology by one of the most creative thinkers working in computer science today. As Peter J. Bentley explains, the next giant step in computing technology is already under way as computer scientists attempt to create digital universes that replicate the natural world. Within these digital universes, we will evolve solutions to problems, construct digital brains that can learn and think, and use immune systems to trap and destroy computer viruses. The biological world is the model for the next generation of computer software. By adapting the principles of biology, computer scientists will make it possible for computers to function as the natural world does. In practical terms, this will mean that we will soon have "smart" devices, such as houses that will keep the temperature as we like it and automobiles that will start only for drivers they recognize (through voice recognition or other systems) and that will navigate highways safely and with maximum fuel efficiency. Computers will soon be powerful enough and small enough that they can become part of clothing. "Digital agents" will be able to help us find a bank or restaurant in a city that we have never visited before, even as we walk through the airport. Miniature robots may even be incorporated into our bodies to monitor our health. Digital Biology is also an exploration of biology itself from a new perspective. We must understand how nature works in its most intimate detail before we can use these same biological processes inside our computers. Already scientists engaged in this work have gained new insights into the elegant simplicity of the natural universe. This is a visionary book, written in accessible, nontechnical language, that explains how cutting-edge computer science will shape our world in the coming decades.

Biology in the Nineteenth Century

Biology in the Nineteenth Century
Author: William Coleman
Publisher: Cambridge University Press
Total Pages: 204
Release: 1977
Genre: Medical
ISBN: 9780521292931
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Essential themes in the development of the life sciences during the nineteenth century.

Synthetic Biology

Synthetic Biology
Author: Huimin Zhao
Publisher: Academic Press
Total Pages: 352
Release: 2013-03-21
Genre: Science
ISBN: 0123978203
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Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomes Highlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development

The Transforming Principle

The Transforming Principle
Author: Maclyn McCarty
Publisher: W. W. Norton & Company
Total Pages: 258
Release: 1986
Genre: Philosophy
ISBN: 9780393304503
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Forty years ago, three medical researchers--Oswald Avery, Colin MacLeod, and Maclyn McCarty--made the discovery that DNA is the genetic material. With this finding was born the modern era of molecular biology and genetics.

Agrobacterium biology and its application to transgenic plant production

Agrobacterium biology and its application to transgenic plant production
Author: Hau-Hsuan Hwang
Publisher: Frontiers Media SA
Total Pages: 167
Release: 2015-06-26
Genre: Botany
ISBN: 2889195740
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The broad host range pathogenic bacterium Agrobacterium tumefaciens has been widely studied as a model system to understand horizontal gene flow, secretion of effector proteins into host cells, and plant-pathogen interactions. Agrobacterium-mediated plant transformation also is the major method for generating transgenic plants for research and biotechnology purposes. Agrobacterium species have the natural ability to conduct interkingdom genetic transfer from bacteria to eukaryotes, including most plant species, yeast, fungi, and even animal cells. In nature, A. tumefaciens causes crown gall disease resulting from expression in plants of auxin and cytokinin biosynthesis genes encoded by the transferred (T-) DNA. Gene transfer from A. tumefaciens to host cells requires virulence (vir) genes that reside on the resident tumor-inducing (Ti) plasmid. In addition to T-DNA, several Virulence (Vir) effector proteins are also translocated to host cells through a bacterial type IV secretion system. These proteins aid in T-DNA trafficking through the host cell cytoplasm, nuclear targeting, and T-DNA integration. Genes within native T-DNAs can be replaced by any gene of interest, making Agrobacterium species important tools for plant research and genetic engineering. In this research topic, we provided updated information on several important areas of Agrobacterium biology and its use for biotechnology purposes.