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Trabecular and Cortical Bone

Trabecular and Cortical Bone
Author: Varsha Subramanium
Publisher: Nova Science Publishers
Total Pages: 0
Release: 2013-10
Genre: Bone
ISBN: 9781628087666

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In this book, the authors present topical research in the study of the morphology, biomechanics and clinical implications of trabecular and cortical bone. Topics discussed include trabecular bone biomechanics and morphology; cortical bone as an enduring depot of bone-seeking contaminants and the evaluation of cortical bone resportion rate on the basis of a contaminant (90SR) measurement in humans; evaluation of apparent stress and strain at fracture of human trabecular bone under quasi-static compression load using micro-CT finite elements simulation; application of computational modelling to predict the effect of exercise on whole bone strength; advancements in cortical bone imaging; morphology of the pelvis (acetabulum) and femur; the release kinetics of bone morphogenetic proteins from demineralised cortical bone grafts; and preservation of cortical bone in oral and maxillofacial surgery procedures.


Image Analysis for Trabecular Bone Properties on Cone-Beam CT Data

Image Analysis for Trabecular Bone Properties on Cone-Beam CT Data
Author: Eva Klintström
Publisher: Linköping University Electronic Press
Total Pages: 73
Release: 2017-10-20
Genre:
ISBN: 9176854345

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Trabecular bone structure as well as bone mineral density (BMD) have impact on the biomechanical competence of bone. In osteoporosis-related fractures, there have been shown to exist disconnections in the trabecular network as well as low bone mineral density. Imaging of bone parameters is therefore of importance in detecting osteoporosis. One available imaging device is cone-beam computed tomography (CBCT). This device is often used in pre-operative imaging of dental implants, for which the trabecular network also has great importance. Fourteen or 15 trabecular bone specimens from the radius were imaged for conducting this in vitro project. The imaging data from one dual-energy X-ray absorptiometry (DXA), two multi-slice computed tomography (MSCT), one high-resolution peripheral quantitative computed tomography (HR-pQCT) and four CBCT devices were segmented using an in-house developed code based on homogeneity thresholding. Seven trabecular microarchitecture parameters, as well as two trabecular bone stiffness parameters, were computed from the segmented data. Measurements from micro-computed tomography (micro-CT) data of the same bone specimens were regarded as gold standard. Correlations between MSCT and micro-CT data showed great variations, depending on device, imaging parameters and between the bone parameters. Only the bone-volume fraction (BV/TV) parameter was stable with strong correlations. Regarding both HR-pQCT and CBCT, the correlations to micro-CT were strong for bone structure parameters as well as bone stiffness parameters. The CBCT device 3D Accuitomo showed the strongest correlations, but overestimated BV/TV more than three times compared to micro-CT. The imaging protocol most often used in clinical imaging practice at our clinic demonstrated strong correlations as well as low radiation dose. CBCT data of trabecular bone can be used for analysing trabecular bone properties, like bone microstructure and bone biomechanics, showing strong correlations to the reference method of micro-CT. The results depend on choice of CBCT device as well as segmentation method used. The in-house developed code based on homogeneity thresholding is appropriate for CBCT data. The overestimations of BV/TV must be considered when estimating bone properties in future clinical dental implant and osteoporosis research.


Bones

Bones
Author: John D. Currey
Publisher: Princeton University Press
Total Pages: 453
Release: 2013-10-31
Genre: Science
ISBN: 1400849500

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This is a comprehensive and accessible overview of what is known about the structure and mechanics of bone, bones, and teeth. In it, John Currey incorporates critical new concepts and findings from the two decades of research since the publication of his highly regarded The Mechanical Adaptations of Bones. Crucially, Currey shows how bone structure and bone's mechanical properties are intimately bound up with each other and how the mechanical properties of the material interact with the structure of whole bones to produce an adapted structure. For bone tissue, the book discusses stiffness, strength, viscoelasticity, fatigue, and fracture mechanics properties. For whole bones, subjects dealt with include buckling, the optimum hollowness of long bones, impact fracture, and properties of cancellous bone. The effects of mineralization on stiffness and toughness and the role of microcracking in the fracture process receive particular attention. As a zoologist, Currey views bone and bones as solutions to the design problems that vertebrates have faced during their evolution and throughout the book considers what bones have been adapted to do. He covers the full range of bones and bony tissues, as well as dentin and enamel, and uses both human and non-human examples. Copiously illustrated, engagingly written, and assuming little in the way of prior knowledge or mathematical background, Bones is both an ideal introduction to the field and also a reference sure to be frequently consulted by practicing researchers.


Musculoskeletal Research and Basic Science

Musculoskeletal Research and Basic Science
Author: Feza Korkusuz
Publisher: Springer
Total Pages: 773
Release: 2015-11-26
Genre: Medical
ISBN: 3319207776

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Strong roots in basic science and research enhance clinical practice. This book is a rich source of information for basic scientists and translational researchers who focus on musculoskeletal tissues and for orthopedic and trauma surgeons seeking relevant up-to-date information on molecular biology and the mechanics of musculoskeletal tissue repair and regeneration. The book opens by discussing biomaterials and biomechanics, with detailed attention to the biologic response to implants and biomaterials and to the surface modification of implants, an important emerging research field. Finite element analysis, mechanical testing standards and gait analysis are covered. All these chapters are strongly connected to clinical applications. After a section on imaging techniques, musculoskeletal tissues and their functions are addressed, the coverage including, for example, stem cells, molecules important for growth and repair, regeneration of cartilage, tendons, ligaments, and peripheral nerves, and the genetic basis of orthopedic diseases. State-of-the-art applications such as platellet rich plasma were included. Imaging is a daily practice of scientists and medical doctors. Recent advancements in ultrasonography, computerized tomography, magnetic resonance, bone mineral density measurements using dual energy X-ray absorptiometry, and scintigraphy was covered following conventional radiography basics. Further extensive sections are devoted to pathology, oncogenesis and tumors, and pharmacology. Structure is always related with function. Surgical anatomy was therefore covered extensively in the last section.


Noninvasive Assessment of Trabecular Bone Architecture and The Competence of Bone

Noninvasive Assessment of Trabecular Bone Architecture and The Competence of Bone
Author: Sharmila Majumdar
Publisher: Springer Science & Business Media
Total Pages: 227
Release: 2012-12-06
Genre: Medical
ISBN: 1461506514

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The study of bone microarchitecture is flourishing because of a recent shift in perspective that has taken researchers beyond utilizing bone mineral density as the primary source of information about certain matters related to bone. In the area of osteoporosis and skeletal changes, bone mineral density (BMD) is widely used for screening, monitoring and assessing therapeutic efficacy, and yet, it is currently accepted that BMD does not fully explain the pathogenesis of osteoporosis, the process of aging, nor mechanisms of therapeutic efficacy. In this context, the study of trabecular microarchitecture has much to contribute. The emerging field of trabecular microarchitecture, however, is diverse, inter-disciplinary and encompasses many different imaging modalities. This volume represents a compilation of papers from world-renowned researchers, reflecting the most current research in the area of noninvasive assessment of trabecular microcarchitecture. This varied research applies sophisticated imaging tools to questions of bone biomechanics at both the basic science and clinical levels. The authors' works range from review articles and research articles to works in progress. Taken together, they offer a foray into the "state of the art" of investigating bone at its most basic levels.


Bone Research in Biomechanics

Bone Research in Biomechanics
Author: G. Lowet
Publisher: IOS Press
Total Pages: 234
Release: 1997
Genre: Biomechanics
ISBN: 9789051993271

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This book focuses on the structure of bone, and its consequences for the mechanical behaviour of the bone structure. The first part of this book focuses on the development of models to predict the adaptation of bone due to changes on the mechanical loading situation (such as provoked by an implant). But far more important than the computer power presently available, the incorporation of knowledge on the biological processes have led to new kinds of models. Next to the development of models itself, the issue of model validation though comparison with clinical data is a main issue addressed in the papers of this symposium. The second part, dealing with the relationship between bone architecture and competence of bone, focuses on the morphology of trabecular bone structure. This work is mainly carried out in the context of research on osteoporosis, and look for the relation between bone structure and fracture risk. The last part is devoted to ultrasound research in bone biomechanics. Several methods have been described for the in vitro and in vivo measurement of ultrasound velocity and attenuation, both on cortical and on trabecular bone. The reader will not only discover the state-of-the-art when reading though this book. This book can give a taste of the fascinating perspectives the research in bone biomechanics still have to offer, even after more than 100 years.


Cancellous Bone

Cancellous Bone
Author: Ardiyansyah Syahrom
Publisher: Springer
Total Pages: 78
Release: 2017-08-05
Genre: Science
ISBN: 981105472X

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This book provides comprehensive mechanobiological insights into bone, including the microstructure of cancellous bone and its realistic loading in the human body. This approach considers different types of loads, i.e. static and dynamic, and the response under uniaxial and multiaxial loading conditions. The book also reviews additional factors influencing biomechanical properties, e.g. fluid transport. In closing, the mechanobiological approach is discussed in the context of the finite element method.


Radiology of Osteoporosis

Radiology of Osteoporosis
Author: Stephan Grampp
Publisher: Springer Science & Business Media
Total Pages: 204
Release: 2013-06-29
Genre: Medical
ISBN: 3662052350

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Due to the aging population in the Western world, osteoporosis has become a major problem which is of interest to several medical disciplines: not only radiologists but also gynecologists, endocrinologists, rheumatologists, and orthopedic surgeons are involved in the management of this widespread condition. Functional imaging is becoming rapidly an important area of diagnostic radiology. Imaging of osteoporosis is another application of this recent addition to the armory of radiology. It is important that radiologists should be fully aware of the range of diagnostic modalities-conventional radiologic methods, dual X-ray absorptiometry, quantitative computed tomography, quantitative ultrasound, magnetic resonance imaging, etc. -that are now available for the diagnosis and the follow-up of osteoporosis, and know how to apply these sophisticated methods in daily clinical practice. Dr. S. Grampp is a radiologist with a longstanding interest in osteoporosis, and his previous publications on this condition are internationally known. He has been very successful in engaging several outstandingly qualified experts to contribute to the indi vidual chapters of this superb book, which provides a omprehensive c overview of our current knowledge of osteoporosis. I am confident that this volume will meet with great interest from radiologists and all other clinicians involved in the care of patients with osteoporosis and will encounter the same success as many previous volumes in this series.


Principles of Bone Biology

Principles of Bone Biology
Author: John P. Bilezikian
Publisher: Academic Press
Total Pages: 2074
Release: 2008-09-29
Genre: Medical
ISBN: 0080568750

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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition


Bioinspired Structures and Design

Bioinspired Structures and Design
Author: Wole Soboyejo
Publisher: Cambridge University Press
Total Pages: 374
Release: 2020-09-17
Genre: Technology & Engineering
ISBN: 1108963447

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Master simple to advanced biomaterials and structures with this essential text. Featuring topics ranging from bionanoengineered materials to bio-inspired structures for spacecraft and bio-inspired robots, and covering issues such as motility, sensing, control and morphology, this highly illustrated text walks the reader through key scientific and practical engineering principles, discussing properties, applications and design. Presenting case studies for the design of materials and structures at the nano, micro, meso and macro-scales, and written by some of the leading experts on the subject, this is the ideal introduction to this emerging field for students in engineering and science as well as researchers.