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| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 68 |
| Release | : 2005-11-17 |
| Genre | : Science |
| ISBN | : 0309097002 |
Download Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens Book in PDF, ePub and Kindle
Toxicogenomics is a discipline that combines expertise in toxicology, genetics, molecular biology, and environmental health to help understand the response of living organisms to stressful environments. The National Research Council convened a workshop to discuss how toxicogenomic data could be applied to improve risk assessments, particularly cancer risk from environmental exposure to chemicals. Risk assessments serve as the basis of many public-health decisions in environmental, occupational, and consumer protection from chemicals. The workshop provided a forum for communities of experts, including those working in "-omics" and those in the policy arena, to discuss where their fields intersect, and how toxicogenomics could address critical knowledge gaps in risk assessments.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 300 |
| Release | : 2007-11-19 |
| Genre | : Science |
| ISBN | : 0309178894 |
Download Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment Book in PDF, ePub and Kindle
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
| Author | : Darrell R. Boverhof |
| Publisher | : John Wiley & Sons |
| Total Pages | : 470 |
| Release | : 2011-10-11 |
| Genre | : Science |
| ISBN | : 1118008987 |
Download Applications of Toxicogenomics in Safety Evaluation and Risk Assessment Book in PDF, ePub and Kindle
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
| Author | : Russell S Thomas |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 524 |
| Release | : 2016-06-16 |
| Genre | : Medical |
| ISBN | : 1782624058 |
Download Toxicogenomics in Predictive Carcinogenicity Book in PDF, ePub and Kindle
Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 135 |
| Release | : 2010-06-07 |
| Genre | : Nature |
| ISBN | : 0309156920 |
Download Toxicity-Pathway-Based Risk Assessment Book in PDF, ePub and Kindle
In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment. The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.
| Author | : Helmut Greim |
| Publisher | : John Wiley & Sons |
| Total Pages | : 838 |
| Release | : 2018-11-05 |
| Genre | : Science |
| ISBN | : 1119135915 |
Download Toxicology and Risk Assessment Book in PDF, ePub and Kindle
Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.
| Author | : Wai Nang Choy |
| Publisher | : CRC Press |
| Total Pages | : 405 |
| Release | : 2001-08-31 |
| Genre | : Medical |
| ISBN | : 0824745221 |
Download Genetic Toxicology and Cancer Risk Assessment Book in PDF, ePub and Kindle
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
| Author | : Wayne G. Landis |
| Publisher | : ASTM International |
| Total Pages | : 430 |
| Release | : 1993 |
| Genre | : Environmental health |
| ISBN | : 0803118600 |
Download Environmental Toxicology and Risk Assessment Book in PDF, ePub and Kindle
| Author | : Harry Salem |
| Publisher | : CRC Press |
| Total Pages | : 344 |
| Release | : 2000-02-17 |
| Genre | : Medical |
| ISBN | : 9781560328377 |
Download Toxicology in Risk Assessment Book in PDF, ePub and Kindle
Toxicology is an integral part of the risk assessment process. In this book, investigators from the scientific and regulatory communities describe recent technical developments in risk assessment embracing toxicology and its allied sciences, risk qualification and characterisation, risk management, and risk communication. Case studies pertaining to current issues involving chemical and environmental risks, including military and industrial scenarios, are presented. Chapters describe value and ethical choices underlying toxicological decisions, economic and legal implications of regulations, understanding risk, and recommendations of the commission on risk assessment and risk management.
| Author | : United States. Congress. Office of Technology Assessment |
| Publisher | : DIANE Publishing |
| Total Pages | : 240 |
| Release | : 1981 |
| Genre | : Cancer |
| ISBN | : 142892437X |
Download Assessment of Technologies for Determining Cancer Risks from the Environment Book in PDF, ePub and Kindle
