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Total Synthesis of Natural Products

Total Synthesis of Natural Products
Author: Jie Jack Li
Publisher: Springer Science & Business Media
Total Pages: 292
Release: 2013-03-14
Genre: Science
ISBN: 3642340652

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'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.


Total Synthesis of Bioactive Natural Products

Total Synthesis of Bioactive Natural Products
Author: Goutam Brahmachari
Publisher: Elsevier
Total Pages: 350
Release: 2019-04-27
Genre: Science
ISBN: 0081028237

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Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule


Efficiency in Natural Product Total Synthesis

Efficiency in Natural Product Total Synthesis
Author: Pei-Qiang Huang
Publisher: John Wiley & Sons
Total Pages: 512
Release: 2018-07-24
Genre: Science
ISBN: 1118940210

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Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals


From Biosynthesis to Total Synthesis

From Biosynthesis to Total Synthesis
Author: Alexandros L. Zografos
Publisher: John Wiley & Sons
Total Pages: 585
Release: 2016-04-18
Genre: Science
ISBN: 1118751736

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Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field


The Total Synthesis of Natural Products, Volume 7

The Total Synthesis of Natural Products, Volume 7
Author: John ApSimon
Publisher: John Wiley & Sons
Total Pages: 483
Release: 2009-09-22
Genre: Science
ISBN: 0470129581

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The appearance of the seventh volume of The Total Synthesis of Natural Products signals the continued health of the art and science of organic synthesis. This new volume contains a chapter updating monoterpene synthesis and reviews the newer areas of leukotrienes and macro-cyclic lactones. The Total Synthesis of Natural Products, Volume Seven forms an integral part of the invaluable working reference begun in Volumes One through Six, to which chemists may turn for the available data on the total synthesis of complex molecules. Lessons learned from the synthetic challenges presented here by various natural products will serve as a sound base for this continually evolving field.


Classics in Total Synthesis

Classics in Total Synthesis
Author: K. C. Nicolaou
Publisher: John Wiley & Sons
Total Pages: 826
Release: 1996-04-11
Genre: Science
ISBN: 3527292314

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K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.


Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products

Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products
Author: Sasadhar Majhi
Publisher: World Scientific
Total Pages: 469
Release: 2023-04-25
Genre: Science
ISBN: 9811268703

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Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.


Efficiency in Natural Product Total Synthesis

Efficiency in Natural Product Total Synthesis
Author: Pei-Qiang Huang
Publisher: John Wiley & Sons
Total Pages: 512
Release: 2018-10-16
Genre: Science
ISBN: 1118605403

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Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals


Heterocycles in Natural Product Synthesis

Heterocycles in Natural Product Synthesis
Author: Krishna C. Majumdar
Publisher: John Wiley & Sons
Total Pages: 648
Release: 2011-06-15
Genre: Science
ISBN: 3527634894

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Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.