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This book gathers selected papers that were submitted to the 2021 International Conference on Digital Science (DSIC 2021) that aims to make available the discussion and the publication of papers on all aspects of single and multidisciplinary research on conference topics. DSIC 2021 was held on October 15–17, 2021. An important characteristic feature of conference is the short publication time and worldwide distribution. Written by respected researchers, the book covers a range of innovative topics related to: digital economics; digital education; digital engineering; digital environmental sciences; digital finance, business and banking; digital health care, hospitals and rehabilitation; digital media; digital medicine, pharma and public health; digital public administration; digital technology and applied sciences. This book may be used for private and professional non-commercial research and classroom use (e.g., sharing the contribution by mail or in hard copy form with research colleagues for their professional non-commercial research and classroom use); for use in presentations or handouts for any level students, researchers, etc.; for the further development of authors’ scientific career (e.g., by citing, and attaching contributions to job or grant application).