Topics On Drug Metabolism PDF Download
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| Author | : James Paxton |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 310 |
| Release | : 2012-02-22 |
| Genre | : Medical |
| ISBN | : 9535100998 |
Download Topics on Drug Metabolism Book in PDF, ePub and Kindle
In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
| Author | : Corina Ionescu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 444 |
| Release | : 2006-02-28 |
| Genre | : Medical |
| ISBN | : 9781402041419 |
Download Drug Metabolism Book in PDF, ePub and Kindle
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
| Author | : Drug Metabolism Discussion Group |
| Publisher | : |
| Total Pages | : |
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Download Interesting Topics in Drug Metabolism Book in PDF, ePub and Kindle
| Author | : Siamak Cyrus Khojasteh |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 222 |
| Release | : 2011-04-07 |
| Genre | : Medical |
| ISBN | : 1441956298 |
Download Drug Metabolism and Pharmacokinetics Quick Guide Book in PDF, ePub and Kindle
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
| Author | : Drug Metabolism Discussion Group |
| Publisher | : |
| Total Pages | : |
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Download Special Topics in Drug Metabolism Book in PDF, ePub and Kindle
| Author | : Wen Xie |
| Publisher | : Academic Press |
| Total Pages | : 296 |
| Release | : 2016-09-12 |
| Genre | : Medical |
| ISBN | : 0128029633 |
Download Drug Metabolism in Diseases Book in PDF, ePub and Kindle
Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic
| Author | : Robert S. Rozman |
| Publisher | : |
| Total Pages | : 229 |
| Release | : 1981 |
| Genre | : Drugs |
| ISBN | : |
Download Fourth Annual Symposium on Interesting Topics in Drug Metabolism Book in PDF, ePub and Kindle
| Author | : G. Gordon Gibson |
| Publisher | : Nelson Thornes |
| Total Pages | : 274 |
| Release | : 2001 |
| Genre | : Medical |
| ISBN | : 9780748760114 |
Download Introduction to Drug Metabolism Book in PDF, ePub and Kindle
Of drug-metabolising reactions. p. 25.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 56 |
| Release | : 1997-08-25 |
| Genre | : Medical |
| ISBN | : 030917452X |
Download Pharmacokinetics and Drug Interactions in the Elderly and Special Issues in Elderly African-American Populations Book in PDF, ePub and Kindle
Reports in the popular press about the increasing longevity of Americans and the aging of the baby boom generation are constant reminders that the American population is becoming older. Consequently, an issue of growing medical, health policy, and social concern is the appropriate and rational use of medications by the elderly. Although becoming older does not necessarily correlate with increasing illness, aging is associated with anatomical and physiological changes that affect how medications are metabolized by the body. Furthermore, aging is often related to an increased frequency of chronic illness (often combined with multiple health problems) and an increased use of medications. Thus, a better understanding of the absorption, distribution, metabolism, and excretion of drugs; of the physiologic responses to those medications; as well as of the interactions among multiple medications is crucial for improving the health of older people.
| Author | : |
| Publisher | : |
| Total Pages | : 115 |
| Release | : 1983 |
| Genre | : |
| ISBN | : |
Download Special topics in drug metabolism Book in PDF, ePub and Kindle
