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| Author | : Ajay K. Banga |
| Publisher | : CRC Press |
| Total Pages | : 396 |
| Release | : 2015-04-23 |
| Genre | : Medical |
| ISBN | : 1466566078 |
Download Therapeutic Peptides and Proteins Book in PDF, ePub and Kindle
There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The c
| Author | : Ajay K. Banga |
| Publisher | : CRC Press |
| Total Pages | : 375 |
| Release | : 2005-09-14 |
| Genre | : Medical |
| ISBN | : 1420039830 |
Download Therapeutic Peptides and Proteins Book in PDF, ePub and Kindle
Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up
| Author | : Puneet Tyagi |
| Publisher | : Academic Press |
| Total Pages | : 318 |
| Release | : 2022-08-18 |
| Genre | : Business & Economics |
| ISBN | : 0128210605 |
Download Oral Delivery of Therapeutic Peptides and Proteins Book in PDF, ePub and Kindle
Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development
| Author | : Chris Van Der Walle |
| Publisher | : Academic Press |
| Total Pages | : 380 |
| Release | : 2011-05-12 |
| Genre | : Science |
| ISBN | : 9780123849366 |
Download Peptide and Protein Delivery Book in PDF, ePub and Kindle
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
| Author | : Ved Srivastava |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 572 |
| Release | : 2019-08-28 |
| Genre | : Science |
| ISBN | : 1788014332 |
Download Peptide Therapeutics Book in PDF, ePub and Kindle
Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 408 |
| Release | : 2018-04-18 |
| Genre | : Science |
| ISBN | : 012814341X |
Download Therapeutic Proteins and Peptides Book in PDF, ePub and Kindle
Therapeutic Proteins and Peptides, Volume 112 in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides and their adsorption on plasmonic nanoparticles, Enzymatic approaches of protein-polymer conjugation, Chimeric small antibody fragments as a strategy to deliver therapeutic payloads, Smart cell-penetrating peptide-based techniques for cytoplasmic delivery of therapeutic macromolecules, and more. Describes advances in the discovery and application of therapeutic proteins/peptides which allow better targeting to the site of treatment and cause fewer adverse effects when compared to chemical compounds used for disease treatment Targeted to a very wide audience of specialists, researchers and students Written by well-renown authorities in their field Includes a number of high quality illustrations, figures and tables
| Author | : Lars Hovgaard |
| Publisher | : CRC Press |
| Total Pages | : 395 |
| Release | : 2012-11-14 |
| Genre | : Medical |
| ISBN | : 1439853886 |
Download Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition Book in PDF, ePub and Kindle
The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product. Providing integrated solutions, this book discusses: The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology The physicochemical characteristics and stability of peptides and proteins The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids The opportunities and challenges of non-parenteral delivery of peptides and proteins Risk factors, specifically the development of an unwanted immune response A simulation approach to describe the fate of peptides and proteins upon administration to a biological system The documentation required to register a protein-based drug Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.
| Author | : Randall J. Mrsny |
| Publisher | : CRC Press |
| Total Pages | : 288 |
| Release | : 2009-10-19 |
| Genre | : Medical |
| ISBN | : 1420078070 |
Download Proteins and Peptides Book in PDF, ePub and Kindle
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is
| Author | : Ulo Langel |
| Publisher | : CRC Press |
| Total Pages | : 440 |
| Release | : 2009-11-18 |
| Genre | : Medical |
| ISBN | : 1439882045 |
Download Introduction to Peptides and Proteins Book in PDF, ePub and Kindle
Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform
| Author | : Daniel R. Marshak |
| Publisher | : Cold Spring Harbor Laboratory Press |
| Total Pages | : 378 |
| Release | : 1988 |
| Genre | : Medical |
| ISBN | : |
Download Therapeutic Peptides and Proteins Book in PDF, ePub and Kindle
