Theoretical And Experimental Characterization Of Time Dependent Signatures Of Acoustic Wave Based Biosensors PDF Download
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| Author | : Sang Hun Lee |
| Publisher | : |
| Total Pages | : |
| Release | : 2006 |
| Genre | : Acoustic surface waves |
| ISBN | : |
Download Theoretical and Experimental Characterization of Time-dependent Signatures of Acoustic Wave Based Biosensors Book in PDF, ePub and Kindle
The object of this thesis research is to facilitate the appraisal and analysis of the signatures of the modern acoustic wave biosensors, as well as to improve the experimental methodology to enhance sensor performance. For this purpose, both theoretical characterization of acoustic wave sensor signatures and experimental studies for the most frequently used acoustic wave biosensors, the liquid phase QCM (quartz crystal microbalance) and the vapor phase SAW (surface acoustic wave) sensors, are presented. For the study of SAW vapor phase detection, the author fabricated different types of two-port SAW resonator sensors on quartz substrates and designed and performed a significant number of detection experiments. These were conducted both with calibrated or known target samples under laboratory conditions at Georgia Tech Hunt Lab and with samples of unknown concentrations such as seized crack cocaine (courtesy of Georgia Bureau of Investigation, GBI) to see the sensors capability to work in the field conditions. In addition, the dependence of the SAW sensor signatures on specific locations of the surface perturbation was investigated to account for some observed abnormal responses. Finally, a novel approach to classify and visualize chemically analogous substances is introduced. The author expects that the thesis work herein may contribute to the study of the modern acoustic wave biosensors which includes but is not limited to: the establishment of underpinning theory that will aid in the evaluation of the signatures; the practical aspects of design and fabrication of SAW devices specific to the vapor phase immunoassay; the development of efficient experimental methodologies; the strategic immobilization of a biolayer on SAW resonator based biosensors; and, the acquisition of reference data for the development of commercial acoustic wave sensors.
| Author | : D. S. Ballantine Jr. |
| Publisher | : Elsevier |
| Total Pages | : 451 |
| Release | : 1996-10-21 |
| Genre | : Science |
| ISBN | : 0080523331 |
Download Acoustic Wave Sensors Book in PDF, ePub and Kindle
Written by an interdisciplinary group of experts from both industry and academia, Acoustic Wave Sensors provides an in-depth look at the current state of acoustic wave devices and the scope of their use in chemical, biochemical, and physical measurements, as well as in engineering applications. Because of the inherent interdisciplinary applications of these devices, this book will be useful for the chemist and biochemist interested in the use and development ofthese sensors for specific applications; the electrical engineer involved in the design and improvement of these devices; the chemical engineer and the biotechnologist interested in using these devices for process monitoring and control; and the sensor community at large. Provides in-depth comparison and analyses of different types of acoustic wave devices Discusses operating principles and design considerations Includes table of relevant material constants for quick reference Presents an extensive review of current uses of these devices for chemical, biochemical, and physical measurements, and engineering applications
| Author | : Mandek Richardson |
| Publisher | : |
| Total Pages | : |
| Release | : 2015 |
| Genre | : Biogeochemistry |
| ISBN | : |
Download Theoretical And Experimental Investigations To Improve The Performance Of Surface Acoustic Wave (SAW) Biosensors Book in PDF, ePub and Kindle
The objective of this dissertation is to improve the performance of surface acoustic wave (SAW) biosensors for use in point-of-care-testing (POCT) applications. SAW biosensors have the ability to perform fast, accurate detection of an analyte in real time without the use of labels. However, the technology suffers from the inability to differentiate between specific and non-specific binding. Due to this limitation, direct testing of bodily fluids using SAW sensors to accurately determine an analyte's concentration is difficult. In addition, these sensors are challenged by the need to detect small concentrations of a biomarker that are typically required to give a clinical diagnosis. Sensitivity, selectivity and reliability are three critical aspects for any sensing platform. To improve sensitivity the delay path of a SAW sensor has been modified with microcavities filled with various materials. These filled cavities increased sensitivity by confining wave energy to the surface by way of constructive interference and waveguiding. Thus, the improved sensitivity will result in a lower limit of detection. In addition, insertion loss is decreased as a consequence of increased wave confinement to the surface. Sensor selectivity and reliability are adversely affected by non-specific binding of unwanted species present in a sample. To address this issue a multifunctional SAW sensor is presented. The sensor consists of two SAW delay lines oriented orthogonal to each on ST-quartz in order to generate two distinct wave modes. One wave mode is used for sensing while the other is used to remove loosely bound material. By using the same transduction mechanism for both removal and sensing, the sensor chip is simplified and complex electronics are avoided. The findings of this research involve the technological advances for SAW biosensors that make their use in POCT possible.
| Author | : Onursal Onen |
| Publisher | : |
| Total Pages | : |
| Release | : 2013 |
| Genre | : |
| ISBN | : |
Download Analytical Modeling, Perturbation Analysis and Experimental Characterization of Guided Surface Acoustic Wave Sensors Book in PDF, ePub and Kindle
In this dissertation, guided surface acoustic wave sensors were investigated theoretically and experimentally in detail for immunosensing applications. Shear horizontal polarized guided surface acoustic wave propagation for mass loading sensing applications was modeled using analytical modeling and characterized by perturbation analysis. The model verification was performed experimentally and a surface acoustic wave immunosensor case study was presented. The results of the immunosensing were also investigated using the perturbation analysis. Guided surface acoustic wave propagation problem was investigated in detail for gravimetric (or mass loading) guided wave sensors, more specifically for immunosensors. The analytical model was developed for multilayer systems taking viscoelasticity into account. The closed form algebraic solutions were obtained by applying appropriate boundary conditions. A numerical approach was used to solve dispersion equation. Detailed parametric investigation of dispersion curves was conducted using typical substrate materials and guiding layers. Substrate types of ST-cut quartz, 41° YX lithium Niobate and 36° YX lithium tantalate with guiding layers of silicon dioxide, metals (chromium and gold), and polymers (Parylene-C and SU-8) were investigated. The effects of frequency and degree of viscoelasticity were also studied. The results showed that frequency only has effect on thickness with same shaped dispersion curves. Dispersion curves were found to be unaffected by the degree of viscoelasticity. It was also observed that when there was a large shear velocity difference between substrate and guiding layer, a transition region with a gradual decrease in phase velocity was obtained. However, when shear velocities were close, a smooth transition was observed. Furthermore, it was observed that, large density differences between substrate and guiding layer resulted in sharp and with nearly constant slope transition.
| Author | : Qingjun Liu |
| Publisher | : Artech House |
| Total Pages | : 291 |
| Release | : 2009-10 |
| Genre | : Medical |
| ISBN | : 1596934409 |
Download Cell-based Biosensors Book in PDF, ePub and Kindle
Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
| Author | : Thomas Laurell |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 593 |
| Release | : 2014-12-08 |
| Genre | : Technology & Engineering |
| ISBN | : 1849737061 |
Download Microscale Acoustofluidics Book in PDF, ePub and Kindle
The manipulation of cells and microparticles within microfluidic systems using external forces is valuable for many microscale analytical and bioanalytical applications. Acoustofluidics is the ultrasound-based external forcing of microparticles with microfluidic systems. It has gained much interest because it allows for the simple label-free separation of microparticles based on their mechanical properties without affecting the microparticles themselves. Microscale Acoustofluidics provides an introduction to the field providing the background to the fundamental physics including chapters on governing equations in microfluidics and perturbation theory and ultrasound resonances, acoustic radiation force on small particles, continuum mechanics for ultrasonic particle manipulation, and piezoelectricity and application to the excitation of acoustic fields for ultrasonic particle manipulation. The book also provides information on the design and characterization of ultrasonic particle manipulation devices as well as applications in acoustic trapping and immunoassays. Written by leading experts in the field, the book will appeal to postgraduate students and researchers interested in microfluidics and lab-on-a-chip applications.
| Author | : |
| Publisher | : |
| Total Pages | : 2316 |
| Release | : 1993 |
| Genre | : Electrical engineering |
| ISBN | : |
Download Science Abstracts Book in PDF, ePub and Kindle
| Author | : |
| Publisher | : |
| Total Pages | : 1948 |
| Release | : 1997 |
| Genre | : Electrical engineering |
| ISBN | : |
Download Electrical & Electronics Abstracts Book in PDF, ePub and Kindle
| Author | : L. Melo |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 679 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9401118248 |
Download Biofilms - Science and Technology Book in PDF, ePub and Kindle
Biofilms -- Science and Technology covers the main topics of biofilm formation and activity, from basic science to applied aspects in engineering and medicine. The book presents a masterly discussion of microbial adhesion, the metabolism of microorganisms in biofilms, modelling of mass transfer and biological reaction within biofilms, as well as the behaviour of these microbial communities in industry (waste water treatment, heat exchanger biofouling, membranes, food processing) and in medicine (teeth, implants, prosthetic devices). Laboratory techniques and industrial monitoring methods are also presented. The book is directed at readers at the postgraduate level and is organised as a textbook, containing 11 chapters, a glossary, and a detailed subject index.
| Author | : Kourosh Kalantar-zadeh |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 502 |
| Release | : 2007-09-19 |
| Genre | : Technology & Engineering |
| ISBN | : 0387680233 |
Download Nanotechnology-Enabled Sensors Book in PDF, ePub and Kindle
Nanotechnology provides tools for creating functional materials, devices, and systems by controlling materials at the atomic and molecular scales and making use of novel properties and phenomena. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.
