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The Wild Mouse in Immunology

The Wild Mouse in Immunology
Author: Michael Potter
Publisher: Springer Science & Business Media
Total Pages: 393
Release: 2012-12-06
Genre: Medical
ISBN: 3642713041
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The present volume of "Current Topics in Microbiology and Immunology" is a series of papers on subjects that are relevant to the growing use of 'wild mice' in immunological, microbiological and genetical research. 'Wild mice' is a jargonistic term that is used chiefly in the laboratory to refer to the naturally living forms of house mice (Mus musculus) and also other species closely related to M. musculus. This group of species is designated by systematists as the genus Mus. Immunologists began 20 years ago to study the polymorphisms of 1mmunoglobulins and major histocompatibility complex antigens in wild mice. An extrordinary extension of the highly polymorphic array of phenotypes known in inbred mice was encountered. Breeding stocks of wild mice were brought into the laboratory. This included not only M. musculus but a)so many of the available species in the genus Mus-from Southeast Asia ~nd Europe. This availability led to other comparisons of 'wild' and inbred mice and the discovery of other new and interesting phenotypes and genotypes. It became apparent that inbred strains of mice provided only a limited window for viewing the genetic diversity of Mus musculus.

Microbiome in Human Health and Disease

Microbiome in Human Health and Disease
Author: Pallaval Veera Bramhachari
Publisher: Springer Nature
Total Pages: 306
Release: 2021-10-18
Genre: Medical
ISBN: 9811631565
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The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.

Wild Immunology—The Answers Are Out There

Wild Immunology—The Answers Are Out There
Author: Gregory M. Woods
Publisher: Frontiers Media SA
Total Pages: 191
Release: 2019-03-20
Genre:
ISBN: 2889458091
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“Go into partnership with nature; she does more than half the work and asks none of the fee.” - Martin H. Fisher. Nature has undertaken an immense amount of work throughout evolution. The evolutionary process has provided a power of information that can address key questions such as - Which immune molecules and pathways are conserved across species? Which molecules and pathways are exploited by pathogens to cause disease? What methods can be broadly used or readily adapted for wild immunology? How does co-infection and exposure to a dynamic environment affect immunity? Section 1 addresses these questions through an evolutionary approach. Laboratory mice have been instrumental in dissecting the nuances of the immune system. The first paper investigates the immunology of wild mice and reviews how evolution and ecology sculpt differences in the immune responses of wild mice and laboratory mice. A better understanding of wild immunology is required and sets the scene for the subsequent papers. Although nature doesn't ask for a fee, it is appropriate that nature is repaid in one form or another. The translational theme of the second section incorporates papers that translate wild immunology back to nature. But any non-human, non-laboratory mouse research environment is hindered by a lack of research tools, hence the underlying theme throughout the second section. Physiological resource allocation is carefully balanced according to the most important needs of the body. Tissue homeostasis can involve trade-offs between energy requirements of the host and compensatory mechanisms to respond to infection. The third section comprises a collection of papers that employ novel strategies to understand how the immune system is compensated under challenging physiological situations. Technology has provided substantial advances in understanding the immune system at cellular and molecular levels. The specificity of these tools (e.g. monoclonal antibodies) often limits the study to a specific species or strain. A consequence of similar genetic sequences or cross-reactivity is that the technology can be adapted to wild species. Section 4 provides two examples of probing wild immunology by adapting technology developed for laboratory species.

Genetics in Wild Mice

Genetics in Wild Mice
Author: Kazuo Moriwaki
Publisher:
Total Pages: 368
Release: 1994
Genre: Medical
ISBN:
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Nutrient Requirements of Laboratory Animals,

Nutrient Requirements of Laboratory Animals,
Author: National Research Council
Publisher: National Academies Press
Total Pages: 188
Release: 1995-02-01
Genre: Science
ISBN: 0309051266
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In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

The Mouse in Biomedical Research

The Mouse in Biomedical Research
Author:
Publisher: Academic Press
Total Pages: 0
Release: 2006-12-15
Genre: Science
ISBN: 9780123694546
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In no other species of animal has such a wealth of experimental data been utilized for scientific pursuits. Now in its Second Edition, this Four Volume Set is dedicated to the understanding of the mouse and its role in scientific research. This valuable compendium serves as a standard reference source of information for students embarking on scientific careers, specialists in laboratory animal science, technicians in both animal care and research, and the broad scientific community. This set is also sold individually and covers History, Wild Mice, and Genetics; Diseases; Normative Biology, Husbandry, and Models; and Immunology. Volume 1: History, Wild Mice, and Genetics KEY FEATURES: . A primer for scientists new to the field of mouse research . Information about the history, biology and genomics of the laboratory mouse (Mus musculus) . Mouse origins and relationships covered in chapters on history, evolutionary taxonomy and wild mice . Mouse genetics and genomics discussed in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome . Use of the mouse as a model system for basic biomedical research described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation Volume 2: Diseases KEY FEATURES: . New format by discussing specific disease causing microorganisms versus the format used in the first edition which discussed infectious diseases affecting specific organs and tissues . Consists of 26 chapters subdivided into RNA viruses and DNA viruses, mycotic, and parasitic infections. . Provides updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens . Offers information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter Volume 3: Normative Biology, Husbandry, and Models KEY FEATURES: . Encompasses 23 chapters with a broad overview on the laboratory mouse's normative biology, husbandry, and its use as a model in biomedical research. . Includes chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. . Discusses management, nutrition, gnotobiotics and disease surveillance . Provides analysis of the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases Volume 4: Immunology KEY FEATURES: . A complete new addition to this series, dedicated to mouse immunology including both the innate and adaptive immune systems . Based on the mouse as a choice model when studying immunity in man-arguably more is known about the immune system in mice than any other species except man . Chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells NEW TO THIS EDITION: * Over 50% new material * Each volume contains 4-color page inserts with indispensable figures * Greatly expanded sections on genetics including: the mouse genome, gene mapping, and gene therapy * Information on newly recognized disease-causing organisms, such as mouse parvovirus and Helicobacter * A volume entirely devoted to mouse immunology * New section on stem cell biology * Each of the four volumes are available individually

Advances in Network Clustering and Blockmodeling

Advances in Network Clustering and Blockmodeling
Author: Patrick Doreian
Publisher: John Wiley & Sons
Total Pages: 425
Release: 2020-02-03
Genre: Mathematics
ISBN: 1119224705
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Provides an overview of the developments and advances in the field of network clustering and blockmodeling over the last 10 years This book offers an integrated treatment of network clustering and blockmodeling, covering all of the newest approaches and methods that have been developed over the last decade. Presented in a comprehensive manner, it offers the foundations for understanding network structures and processes, and features a wide variety of new techniques addressing issues that occur during the partitioning of networks across multiple disciplines such as community detection, blockmodeling of valued networks, role assignment, and stochastic blockmodeling. Written by a team of international experts in the field, Advances in Network Clustering and Blockmodeling offers a plethora of diverse perspectives covering topics such as: bibliometric analyses of the network clustering literature; clustering approaches to networks; label propagation for clustering; and treating missing network data before partitioning. It also examines the partitioning of signed networks, multimode networks, and linked networks. A chapter on structured networks and coarsegrained descriptions is presented, along with another on scientific coauthorship networks. The book finishes with a section covering conclusions and directions for future work. In addition, the editors provide numerous tables, figures, case studies, examples, datasets, and more. Offers a clear and insightful look at the state of the art in network clustering and blockmodeling Provides an excellent mix of mathematical rigor and practical application in a comprehensive manner Presents a suite of new methods, procedures, algorithms for partitioning networks, as well as new techniques for visualizing matrix arrays Features numerous examples throughout, enabling readers to gain a better understanding of research methods and to conduct their own research effectively Written by leading contributors in the field of spatial networks analysis Advances in Network Clustering and Blockmodeling is an ideal book for graduate and undergraduate students taking courses on network analysis or working with networks using real data. It will also benefit researchers and practitioners interested in network analysis.

Analysis of Biological Networks

Analysis of Biological Networks
Author: Björn H. Junker
Publisher: John Wiley & Sons
Total Pages: 278
Release: 2011-09-20
Genre: Computers
ISBN: 1118209915
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An introduction to biological networks and methods for their analysis Analysis of Biological Networks is the first book of its kind to provide readers with a comprehensive introduction to the structural analysis of biological networks at the interface of biology and computer science. The book begins with a brief overview of biological networks and graph theory/graph algorithms and goes on to explore: global network properties, network centralities, network motifs, network clustering, Petri nets, signal transduction and gene regulation networks, protein interaction networks, metabolic networks, phylogenetic networks, ecological networks, and correlation networks. Analysis of Biological Networks is a self-contained introduction to this important research topic, assumes no expert knowledge in computer science or biology, and is accessible to professionals and students alike. Each chapter concludes with a summary of main points and with exercises for readers to test their understanding of the material presented. Additionally, an FTP site with links to author-provided data for the book is available for deeper study. This book is suitable as a resource for researchers in computer science, biology, bioinformatics, advanced biochemistry, and the life sciences, and also serves as an ideal reference text for graduate-level courses in bioinformatics and biological research.

The Mouse in Biomedical Research

The Mouse in Biomedical Research
Author: Henry Foster
Publisher: Elsevier
Total Pages: 321
Release: 1981-01-01
Genre: Science
ISBN: 0323156061
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The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.

Origins of Inbred Mice

Origins of Inbred Mice
Author: Herbert C. III Morse
Publisher: Elsevier
Total Pages: 737
Release: 2012-12-02
Genre: Nature
ISBN: 0323142834
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Origins of Inbred Mice documents the proceedings of a symposium on the state of knowledge on inbred mice held in Bethesda, Maryland, in 1978. The book is organized into seven parts. Part I provides introductory remarks on the history of the development of inbred mice. Part II contains papers that examine mutations of inbred strains of mice. Part III contains studies dealing with viruses that affect inbred mice, including those that cause leukemia and mammary tumors. Part IV examines histocompatibility genes and their antigens; cell surface antigens of mouse leukemia; the characteristics of genes of the Tla region of the mouse; and the use of recombinant inbred strains in gene mapping. Part V presents studies on differences among sublines of inbred mouse strains. The papers in Part VI focus on wild mice, covering their classification and biochemical polymorphisms. Finally, Part VIII discusses the viruses, T locus, and histocompatibility antigens of wild mice.