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The Slow Inward Current and Cardiac Arrhythmias

The Slow Inward Current and Cardiac Arrhythmias
Author: Douglas P. Zipes
Publisher: Springer Science & Business Media
Total Pages: 518
Release: 2012-12-06
Genre: Medical
ISBN: 9400988907

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Since Paul Cranefield published his monograph, The Conduction of the Cardiac Impulse, in 1975, much has been learned about the role of the slow inward current in cardiac electrophysiology. Because of this expanse in know ledge, both basic and clinical, it appeared reasonable to review in a mono graph once again what was known. When Martinus Nijhoff first approached us to undertake the task of updating this information, we were initially reluctant for several reasons. First, we did not feel that the subject could be adequately and thoroughly reviewed, from the cell to the bedside, by a single person. Second, time constraints on all of us precluded even attempting such a task. However, we were encouraged by several of our friends (' egged on' one might even say, since they wished the job done but did not want to do it themselves!) who promised faithfully to contribute chapters on time if we accepted the task. So we did, and most of them did also.


Cardiac Repolarization

Cardiac Repolarization
Author: Ihor Gussak
Publisher: Springer Science & Business Media
Total Pages: 549
Release: 2003-03-13
Genre: Medical
ISBN: 1592593623

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A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.


Anesthetic Pharmacology

Anesthetic Pharmacology
Author: Alex S. Evers
Publisher: Cambridge University Press
Total Pages: 2902
Release: 2011-03-10
Genre: Medical
ISBN: 1139497022

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In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.


Cardiovascular Physiology Concepts

Cardiovascular Physiology Concepts
Author: Richard E. Klabunde
Publisher: Lippincott Williams & Wilkins
Total Pages: 689
Release: 2020-12-01
Genre: Medical
ISBN: 1975150090

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Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice.


Cardiac Arrhythmias

Cardiac Arrhythmias
Author: Wilbert S. Aronow
Publisher: BoD – Books on Demand
Total Pages: 164
Release: 2014-02-12
Genre: Medical
ISBN: 953511221X

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This book is useful for physicians taking care of patients with cardiac arrhythmias and includes six chapters written by experts in their field. Chapter 1 discusses basic mechanisms of cardiac arrhythmias. Chapter 2 discusses the chronobiological aspects of the impact of apnoic episodes on ventricular arrhythmias. Chapter 3 discusses navigation, detection, and tracking during cardiac ablation interventions. Chapter 4 discusses epidemiology and pathophysiology of ventricular arrhythmias in several noncardiac diseases, methods used to assess arrhythmia risk, and their association with long-term outcomes. Chapter 5 discusses the treatment of ventricular arrhythmias including indications for implantation of an AICD for primary and for secondary prevention in patients with and without congestive heart failure. Chapter 6 discusses surgical management of atrial fibrillation.


Clinical Guide to Cardiology

Clinical Guide to Cardiology
Author: Christian Fielder Camm
Publisher: John Wiley & Sons
Total Pages: 440
Release: 2016-03-07
Genre: Medical
ISBN: 1118755332

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Clinical Guide to Cardiology is a quick-reference resource, packed full of bullet points, diagrams, tables and algorithms for the key concepts and facts for important presentations and conditions within cardiology. It provides practical, evidence-based information on interventions, investigations, and the management of clinical cardiology. Key features include: A clear evidence-base providing key guidelines and clinical trials in each chapter Coverage of examination techniques, common conditions, imaging modalities (including ECGs, chest X-rays, MRI and CT), interventional therapies, and pharmacology A companion website at www.wiley.com/go/camm/cardiology featuring audio clips, developed for differing levels of knowledge, that explain key concepts or an area in greater detail, as well as numerous additional clinical case studies, audio scripts, and self-assessment material


Regenerative Pharmacology

Regenerative Pharmacology
Author: George J. Christ
Publisher: Cambridge University Press
Total Pages: 361
Release: 2013-04-15
Genre: Medical
ISBN: 1107354730

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Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.


Cardiac Adaptation in Heart Failure

Cardiac Adaptation in Heart Failure
Author: J. Holtz
Publisher: Steinkopff
Total Pages: 0
Release: 2011-12-21
Genre: Medical
ISBN: 9783642724794

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Traditionally, cardiac hypertrophy is regarded as an adaptation of the heart to permanent mechanical overload. Regardless of the fact that many different and often unknown primary causes can result in heart failure, mechanical overload and myocardial hypertrophy is found in almost all forms of manifest chronic heart failure (apart from failure due to extramyocardial hindrances to inflow or to relaxation). However, the reactive enlargement of myocardial mass in response to an enhanced hemodynamic burden appears to be a double-edged sword. Obviously, the hypertrophy helps to reduce the enhanced ventricular wall stress in heart failure by adding contractile units to the overdistended chamber wall. However, in recent years it became clear that this adaptive hypertrophic process is rather complex and may include problematic facets. The adaptive hypertrophy includes proliferation of the nonmyocyte cardiac cells as well as substantial alterations in the phenotype of the growing myocytes due to differential changes in gene expression.