The Selected Papers Of Denis Noble Cbe Frs PDF Download
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| Author | : Denis Noble |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2012 |
| Genre | : Biological models |
| ISBN | : 9781848168428 |
Download The Selected Papers of Denis Noble CBE FRS Book in PDF, ePub and Kindle
This is a scientific and philosophical autobiography written around a collection of Denis Noble's most significant papers. It traces a remarkable journey from na ve reductionism to a rigorous systems approach to living systems. It is rigorous because Denis Noble was one of the first biologists to construct computer models of cells and organs of the body. His theoretical work is entirely mathematically based, with no room for ambiguity. Far from the denigration of the systems approach as holistic 'hand-waving', his work is now regarded by pharmaceutical companies and regulators as the gold standard of modelling in the development of new medication. Systems Biology is an idea in search of a definition. This book explains why this is true: it is an approach rather than a subject. Denis Noble's work is one of the clearest examples of the systems approach in practice since it reveals the nature of some of the forms of downward causation in multilevel analysis. The story will delight readers who like to see how scientific controversy is resolved, since many of the developments described in each chapter were highly controversial when they occurred.
| Author | : Denis Noble |
| Publisher | : OUP Oxford |
| Total Pages | : 169 |
| Release | : 2008-02-14 |
| Genre | : Science |
| ISBN | : 0191578800 |
Download The Music of Life Book in PDF, ePub and Kindle
What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.
| Author | : Peter Coveney |
| Publisher | : Princeton University Press |
| Total Pages | : 336 |
| Release | : 2023-03-28 |
| Genre | : Science |
| ISBN | : 0691223408 |
Download Virtual You Book in PDF, ePub and Kindle
The visionary science behind the digital human twins that will enhance our health and our future Virtual You is a panoramic account of efforts by scientists around the world to build digital twins of human beings, from cells and tissues to organs and whole bodies. These virtual copies will usher in a new era of personalized medicine, one in which your digital twin can help predict your risk of disease, participate in virtual drug trials, shed light on the diet and lifestyle changes that are best for you, and help identify therapies to enhance your well-being and extend your lifespan—but thorny challenges remain. In this deeply illuminating book, Peter Coveney and Roger Highfield reveal what it will take to build a virtual, functional copy of a person in five steps. Along the way, they take you on a fantastic voyage through the complexity of the human body, describing the latest scientific and technological advances—from multiscale modeling to extraordinary new forms of computing—that will make “virtual you” a reality, while also considering the ethical questions inherent to realizing truly predictive medicine. With an incisive foreword by Nobel Prize–winning biologist Venki Ramakrishnan, Virtual You is science at its most astounding, showing how our virtual twins and even whole populations of virtual humans promise to transform our health and our lives in the coming decades.
| Author | : Malcolm S. Gordon |
| Publisher | : CRC Press |
| Total Pages | : 364 |
| Release | : 2017-05-25 |
| Genre | : Medical |
| ISBN | : 1351966197 |
Download Animal Locomotion Book in PDF, ePub and Kindle
Animal Locomotion: Physical Principles and Adaptations is a professional-level, state of the art review and reference summarizing the current understanding of macroscopic metazoan animal movement. The comparative biophysics, biomechanics and bioengineering of swimming, flying and terrestrial locomotion are placed in contemporary frameworks of biodiversity, evolutionary process, and modern research methods, including mathematical analysis. The intended primary audience is advanced-level students and researchers primarily interested in and trained in mathematics, physical sciences and engineering. Although not encyclopedic in its coverage, anyone interested in organismal biology, functional morphology, organ systems and ecological physiology, physiological ecology, molecular biology, molecular genetics and systems biology should find this book useful.
| Author | : C. A. R. Boyd |
| Publisher | : |
| Total Pages | : 244 |
| Release | : 1993 |
| Genre | : Science |
| ISBN | : |
Download The Logic of Life Book in PDF, ePub and Kindle
A highly challenging collection of essays by eminent scientists on the theme of integrative approaches to physiological questions, this book discusses the changing boundaries between different disciplines in modern experimental biology. The contributors are experts in the fields of integrative physiology, cellular evolution, control mechanisms, endocrinology, and behavioral biology. Conceived as a tribute to the 1993 International Congress of Physiological Sciences, this important work matches the immense challenge of modern biological science at the end of the twentieth century.
| Author | : Jean-Pierre Poirier |
| Publisher | : University of Pennsylvania Press |
| Total Pages | : 541 |
| Release | : 1998 |
| Genre | : Biography & Autobiography |
| ISBN | : 0812216490 |
Download Lavoisier Book in PDF, ePub and Kindle
Originally published in French in 1993 (Editions Pygmalion/Gerard Watelet, Paris), and expanded and revised for this translation. The founder of modern chemistry, Lavoisier (1743-1794) was active on commisions connected with agriculture, gunpowder, banking, and finance, and was ultimately executed during the Reign of Terror. This biography recounts Lavoisier's scientific accomplishments and his role in the chemical revolution and early history of organic chemistry and physiology; but it is in the examination of his political and economic activities and accomplishments that it breaks new ground. Annotation copyrighted by Book News, Inc., Portland, OR
| Author | : Denis Noble |
| Publisher | : Cambridge University Press |
| Total Pages | : 315 |
| Release | : 2017 |
| Genre | : Medical |
| ISBN | : 1107176247 |
Download Dance to the Tune of Life Book in PDF, ePub and Kindle
This book formulates a relativistic theory of biology, challenging the common gene-centred view of organisms.
| Author | : Harry M Markowitz |
| Publisher | : World Scientific |
| Total Pages | : 719 |
| Release | : 2009-03-03 |
| Genre | : Business & Economics |
| ISBN | : 981447021X |
Download Harry Markowitz: Selected Works Book in PDF, ePub and Kindle
Harry M Markowitz received the Nobel Prize in Economics in 1990 for his pioneering work in portfolio theory. He also received the von Neumann Prize from the Institute of Management Science and the Operations Research Institute of America in 1989 for his work in portfolio theory, sparse matrices and the SIMSCRIPT computer language. While Dr Markowitz is well-known for his work on portfolio theory, his work on sparse matrices remains an essential part of linear optimization calculations. In addition, he designed and developed SIMSCRIPT — a computer programming language. SIMSCRIPT has been widely used for simulations of systems such as air transportation and communication networks.This book consists of a collection of Dr Markowitz's most important works in these and other fields.
| Author | : James Campbell |
| Publisher | : Open Court Publishing |
| Total Pages | : 328 |
| Release | : 1995 |
| Genre | : Philosophy |
| ISBN | : 9780812692853 |
Download Understanding John Dewey Book in PDF, ePub and Kindle
Dewey is the most influential of American social thinkers, and his stock is now rising once more among professional philosophers. Yet there has heretofore been no adequate, readable survey of the full range of Dewey's thought. After an introduction situating Dewey in the context of American social and intellectual history, Professor Campbell devotes Part I to Dewey's general philosophical perspective as it considers humans and their natural home. Three aspects of human nature are most prominent in Dewey's thinking: humans as evolutionary emergents, as essentially social beings, and as problem solvers. Part II examines Dewey's social vision, taking his ethical views as the starting point. Underlying all of Dewey's efforts at social reconstruction are certain assumptions about cooperative enquiry as a social method, assumptions which Campbell explains and clarifies before evaluating various criticisms of Dewey's ideas. The final chapter discusses Dewey's views on religion.
| Author | : C. Brad Faught |
| Publisher | : Potomac Books, Inc. |
| Total Pages | : 139 |
| Release | : 2013-01-31 |
| Genre | : History |
| ISBN | : 1612341683 |
Download Clive Book in PDF, ePub and Kindle
Robert Clive (1725–1774), later Baron Clive of Plassey, is widely considered the founder of British India. He arrived in Madras as a clerk for the East India Company in 1744. Through timely promotion and a clear affinity for military leadership, he proceeded to consolidate the company's commercial and territorial position in South India before doing the same in the northeast in Bengal. In 1757 company troops under his command defeated the Nawab of Bengal at the Battle of Plassey. This victory set in motion the East India Company's ascendancy over much of India and eventual development into the world's largest transnational trading company at the time. This paved the way for the 1857 creation of the British Raj, which would last for another ninety years. Clive is a fascinating and important historical figure: a lowly company employee who rose to great heights; an informally trained military commander who led company and local Indian troops to a series of stirring victories over local rivals who were supported by the French; a grasping politician who used his great wealth to secure a prominent social position; and, finally, a hounded society notable who, plagued by illness, allegedly took his own life. No one in the early days of the British ventures in India was as well known or as controversial as Clive. Today, when empire and globalism are witnessed and talked about with ease, Clive's position as both a servant of the East India Company and an agent of imperialism makes him a surprisingly resonant figure.
