The Search For Anti Inflammatory Drugs PDF Download
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Author | : Vincent J. Merluzzi |
Publisher | : Springer Science & Business Media |
Total Pages | : 310 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 146159846X |
Download The Search for Anti-Inflammatory Drugs Book in PDF, ePub and Kindle
Perspectives on Anti-Inflammatory Drugs Inflammation is a very complicated process of interrelated events and cas cades that does not allow for an easily defined, focused attack for drug discovery. It is evident from years of research and development that certain classes of compounds (e.g., NSAIDs, steroids, and so on) have had a meas ure of success in alleviating pain and even dampening cellularlhormonal mechanisms involved in the process. Clear, mechanism-related therapies (e.g., for arthritis) and targeted drugs (e.g., for transplantation) have not been available in the past and, in reality, research in inflammation has re lied on more phenomenological approaches for resolving symptoms or on blatant cytoreductive approaches in cases like organ transplantation. In the last decade, approaches that have revealed novel cellular pathways in which intervention is possible for lymphocyte regulation (for example, cyclosporine and FK506) and small molecular weight mediators (e.g., leu kotriene inhibitors) are now either standard therapy or will be in a short time. These latter approaches have been the result of research from the 1970s up to the present.
Author | : Vincent J. Merluzzi |
Publisher | : Birkhäuser |
Total Pages | : 304 |
Release | : 1995-07-01 |
Genre | : Medical |
ISBN | : 9780817636852 |
Download The Search for Anti-Inflammatory Drugs Book in PDF, ePub and Kindle
Perspectives on Anti-Inflammatory Drugs Inflammation is a very complicated process of interrelated events and cas cades that does not allow for an easily defined, focused attack for drug discovery. It is evident from years of research and development that certain classes of compounds (e.g., NSAIDs, steroids, and so on) have had a meas ure of success in alleviating pain and even dampening cellularlhormonal mechanisms involved in the process. Clear, mechanism-related therapies (e.g., for arthritis) and targeted drugs (e.g., for transplantation) have not been available in the past and, in reality, research in inflammation has re lied on more phenomenological approaches for resolving symptoms or on blatant cytoreductive approaches in cases like organ transplantation. In the last decade, approaches that have revealed novel cellular pathways in which intervention is possible for lymphocyte regulation (for example, cyclosporine and FK506) and small molecular weight mediators (e.g., leu kotriene inhibitors) are now either standard therapy or will be in a short time. These latter approaches have been the result of research from the 1970s up to the present.
Author | : |
Publisher | : |
Total Pages | : 952 |
Release | : 1979 |
Genre | : |
ISBN | : 9780387086408 |
Download Anti-inflammatory Drugs Book in PDF, ePub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 288 |
Release | : 2019-07-13 |
Genre | : Medical |
ISBN | : 0128173173 |
Download Drug-Induced Liver Injury Book in PDF, ePub and Kindle
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Author | : Sir John R. Vane |
Publisher | : Springer Science & Business Media |
Total Pages | : 249 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9401090297 |
Download Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors Book in PDF, ePub and Kindle
In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene from COX-I. COX-2 is induced by inflammatory stimuli and by cytokines in migratory and other cells. Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.
Author | : Leobardo Manuel Gómez-Oliván |
Publisher | : Springer Nature |
Total Pages | : 338 |
Release | : 2020-10-14 |
Genre | : Science |
ISBN | : 3030562948 |
Download Non-Steroidal Anti-Inflammatory Drugs in Water Book in PDF, ePub and Kindle
This book gathers the main international research findings on non-steroidal anti-inflammatory drugs (NSAIDs) as emerging contaminants in water. It focuses on the major routes of exposure, and the destinations and life cycles of NSAIDs in water, as well as the manifestations of toxicity in different organisms. It also reviews the methods used in the detection, analysis and quantification of NSAIDs in water as well as the biological and chemical methods of removing them. Lastly, the book offers an overview of the legal frameworks in place and provides conclusions and recommendations for the future. Given its scope, the book is an indispensable resource for scientists in academia and industry, as well as for decision-makers involved in contamination assessment and environmental analysis and NGOs interested in the problem of water contamination by NSAIDs.
Author | : Juan Carlos Kaski |
Publisher | : European Society of Cardiology |
Total Pages | : 961 |
Release | : 2019-05-23 |
Genre | : Medical |
ISBN | : 0198759932 |
Download The ESC Handbook on Cardiovascular Pharmacotherapy Book in PDF, ePub and Kindle
The ESC Handbook on Cardiovascular Pharmacotherapy, based on the most recent guidelines in cardiovascular pharmacology, and containing a comprehensive A-Z formulary of common and less commonly used cardiac drugs and drug groups, provides practical and accessible guidance on all areas of drugprescribing.Previously published as Drugs in Cardiology, this new edition has been developed by the ESC Working Group on Cardiovascular Pharmacology. Pharmacology is an integral aspect in almost all disciplines within cardiology and all cardiologists use cardiovascular drugs.Completely updated and aligned with the ESC Clinical Practice Guidelines for prescribing, this handbook is essential reading for consultants, registrars in training, general practitioners, specialist cardiac nurses and cardiovascular pharmacologists.
Author | : K. D. Rainsford |
Publisher | : Springer Science & Business Media |
Total Pages | : 261 |
Release | : 2013-02-01 |
Genre | : Medical |
ISBN | : 3034804962 |
Download Ibuprofen: Pharmacology, Therapeutics and Side Effects Book in PDF, ePub and Kindle
Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.
Author | : Subash Chandra Gupta |
Publisher | : Springer |
Total Pages | : 479 |
Release | : 2016-09-26 |
Genre | : Medical |
ISBN | : 3319413341 |
Download Anti-inflammatory Nutraceuticals and Chronic Diseases Book in PDF, ePub and Kindle
This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.
Author | : Hyman J. Zimmerman |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 848 |
Release | : 1999 |
Genre | : Medical |
ISBN | : 9780781719520 |
Download Hepatotoxicity Book in PDF, ePub and Kindle
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.