The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis PDF Download
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Author | : Zhouxiao Li |
Publisher | : Frontiers Media SA |
Total Pages | : 693 |
Release | : 2024-01-15 |
Genre | : Science |
ISBN | : 2832537332 |
Download The role of the tumor microenvironment (TME) and relevant novel biomarkers in oncogenesis Book in PDF, ePub and Kindle
Author | : Lars A. Akslen |
Publisher | : Springer |
Total Pages | : 537 |
Release | : 2017-08-02 |
Genre | : Medical |
ISBN | : 331939147X |
Download Biomarkers of the Tumor Microenvironment Book in PDF, ePub and Kindle
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
Author | : Jacinta Serpa |
Publisher | : Springer Nature |
Total Pages | : 430 |
Release | : 2020-03-04 |
Genre | : Medical |
ISBN | : 3030340252 |
Download Tumor Microenvironment Book in PDF, ePub and Kindle
The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Author | : Peter P. Lee |
Publisher | : Springer Nature |
Total Pages | : 326 |
Release | : 2020-03-25 |
Genre | : Medical |
ISBN | : 303038862X |
Download Tumor Microenvironment Book in PDF, ePub and Kindle
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Author | : Debabrata Banerjee |
Publisher | : Springer Nature |
Total Pages | : 171 |
Release | : 2021-12-09 |
Genre | : Medical |
ISBN | : 3030832821 |
Download Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions Book in PDF, ePub and Kindle
Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
Author | : Lars A. Akslen |
Publisher | : Springer Nature |
Total Pages | : 596 |
Release | : 2022-07-12 |
Genre | : Medical |
ISBN | : 303098950X |
Download Biomarkers of the Tumor Microenvironment Book in PDF, ePub and Kindle
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed. Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.
Author | : Z. Kmiec |
Publisher | : Springer Science & Business Media |
Total Pages | : 154 |
Release | : 2013-06-29 |
Genre | : Science |
ISBN | : 3642565530 |
Download Cooperation of Liver Cells in Health and Disease Book in PDF, ePub and Kindle
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Author | : Bharat B. Aggarwal |
Publisher | : Springer |
Total Pages | : 489 |
Release | : 2014-05-12 |
Genre | : Medical |
ISBN | : 3034808372 |
Download Inflammation and Cancer Book in PDF, ePub and Kindle
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author | : Supriya Srivastava |
Publisher | : BoD – Books on Demand |
Total Pages | : 168 |
Release | : 2018-09-19 |
Genre | : Medical |
ISBN | : 178923686X |
Download Histopathology Book in PDF, ePub and Kindle
This book, "Histopathology-An Update" is a comprehensive book that deals with the latest advances in the field of histopathology. This book will be of help to pathologists, clinicians and researchers in the latest update in histopathology of various organs.
Author | : Katarzyna A. Rejniak |
Publisher | : Springer |
Total Pages | : 264 |
Release | : 2016-10-13 |
Genre | : Medical |
ISBN | : 3319420232 |
Download Systems Biology of Tumor Microenvironment Book in PDF, ePub and Kindle
This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.