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The Role of RNF157 in Central Nervous System Development

The Role of RNF157 in Central Nervous System Development
Author: Annika Matz
Publisher:
Total Pages: 0
Release: 2012
Genre:
ISBN:

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Apoptosis or programmed cell death is a crucial event during neuronal development to reduce excessive neurons. In addition, neuronal apoptosis is the cause of many neurodegenerative diseases including Alzheimer's disease or Parkinson's disease. Emerging evidence implicates the ubiquitin-proteasome system (UPS) in apoptosis and neurodegeneration. Ubiquitination of intracellular proteins by E3 ubiquitin ligases brings about degradation by the proteasome or serves as important regulatory modification. RING (Really Interesting New Gene) finger proteins represent the largest group of E3 ligases ...


Regenerative Medicine I

Regenerative Medicine I
Author: Ioannis V. Yannas
Publisher: Springer Science & Business Media
Total Pages: 220
Release: 2005-02-10
Genre: Medical
ISBN: 9783540228714

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With contributions by numerous experts


Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment
Author: National Research Council
Publisher: National Academies Press
Total Pages: 348
Release: 2000-12-21
Genre: Nature
ISBN: 0309070864

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Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.


Drug and Hormonal Resistance in Breast Cancer

Drug and Hormonal Resistance in Breast Cancer
Author: Robert Brent Dickson
Publisher: Prentice Hall PTR
Total Pages: 474
Release: 1995
Genre: Medical
ISBN:

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Featuring contributions from expert authors of international standing, this book explores emerging studies on the success and/or failure of chemotherapy in breast cancer. Covers the clinical resistance of breast cancer to treatment; chemo-hormonal reactions; anti-hormonal resistance; multidrug resistance; and fu/antimetabolites. For cancer and hormonal researchers and development scientists in pharmaceuticals and biomedicine. Previously announced in 7/93 PTR Catalog.


Extracellular Vesicles in Health and Disease

Extracellular Vesicles in Health and Disease
Author: Paul Harrison
Publisher: CRC Press
Total Pages: 484
Release: 2014-05-02
Genre: Medical
ISBN: 9814411981

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Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role in pathogenesis as well as their possible use as biomarkers. This book stems from the first international meeting on "Microvesicles and Nanovesicles in Health and Disease" held at Magdalen College, Oxford, in 2010. The purpose of the meeting was to bring together, for the first time, a range of experts from around the world to discuss the latest advances in this field. Key to the study of these vesicles is the availability of methodologies for their measurement in biological fluids. A major section of the meeting focused on a range of exciting new technologies which have been developed for this purpose. The presentations at this meeting form the basis of this book, which will appeal to basic scientists, clinicians, and those developing technology for the measurement of extracellular vesicles.


Neurocardiology

Neurocardiology
Author: J. Andrew Armour
Publisher: Oxford University Press, USA
Total Pages: 464
Release: 1994
Genre: Law
ISBN:

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New ideas about intrinsic and extrinsic cardiac intrathoracic neurons, the role of spinal cord and medullary and higher center neurons are presented. The final chapters focus on the role that autonomic neurons play in the maintenance of cardiac function in the conscious state as well as in two major clinical conditions, dysrythimias and heart failure.


Ambulatory Blood Pressure Monitoring

Ambulatory Blood Pressure Monitoring
Author: M.D. Weber
Publisher: Springer Science & Business Media
Total Pages: 239
Release: 2013-03-09
Genre: Medical
ISBN: 3662056852

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The availability of new technologies that enable blood pressure to be measured and re corded continuously or repetitively during prolonged observation periods has created ex citing opportunities for studying the physiology of blood pressure regulation and the characteristics of clinical hypertension. Ambulatory blood pressure monitoring has been based on three types of approach. The first of these has utilized an intra-arterial catheter that allows blood pressure to be meas ured directly and continuously during a full 24-hour period. The second approach is based on non-invasive techniques, and utilizes devices capable of automatically inflating conventional arm cuffs and recording blood pressures at pre-set intervals throughout the day. The third, and most simple method, has depended upon semiautomated techniques that require the subject to inflate a cuff at convenient intervals during the period of obser vation. During the last few years, concerted research into these differing techniques has exposed their strengths and shortcomings. Overall, however, there has been a growing perception that these approaches to the measurement of blood pressure might add con siderably to the information obtained in the doctor's office by the traditional single or casual reading. This book summarizes the state of the art in ambulatory blood pressure monitoring.


The New Russian Nationalism

The New Russian Nationalism
Author: John B. Dunlop
Publisher: Praeger
Total Pages: 0
Release: 1985-10-15
Genre: Political Science
ISBN: 0275916650

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