The Role of Oxidative Stress in C. Elegans Aging
Author | : Maike Thamsen |
Publisher | : |
Total Pages | : 0 |
Release | : 2011 |
Genre | : |
ISBN | : |
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Author | : Maike Thamsen |
Publisher | : |
Total Pages | : 0 |
Release | : 2011 |
Genre | : |
ISBN | : |
Author | : David R. Riddle |
Publisher | : CRC Press |
Total Pages | : 408 |
Release | : 2007-04-19 |
Genre | : Medical |
ISBN | : 9781420005523 |
Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Author | : Satomi Miwa |
Publisher | : Springer Science & Business Media |
Total Pages | : 318 |
Release | : 2008-06-17 |
Genre | : Medical |
ISBN | : 1597454206 |
Human aging is a complex phenomenon. This state-of-the-art book discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in humans (following an introduction section of the basics and theory of free radicals). In addition, the major interventions trials of antioxidant supplements in age-related disease, cancer and so forth are reviewed and discussed.
Author | : Richard G. Cutler |
Publisher | : World Scientific |
Total Pages | : 758 |
Release | : 2003 |
Genre | : Medical |
ISBN | : 9789812389978 |
This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.
Author | : Robert C. Roach |
Publisher | : Springer |
Total Pages | : 372 |
Release | : 2003-12-31 |
Genre | : Medical |
ISBN | : 0306480727 |
The International Hypoxia Symposium convenes biannually to bring together international experts from many fields to explore the state of the art in normal and pathophysiological responses to hypoxia. Representatives from five continents and 32 countries joined together in February 2003 for four days in the dramatic mountains of Banff, Alberta. As editors of the Proceedings of the International Hypoxia Symposia, we strive to maintain a 26 six year tradition of presenting a stimulating blend of clinical and basic science papers focused on hypoxia. Topics covered in 2003 include hibernation and hypoxia, hypoxia and fetal development and new advances in high altitude pathophysiology, oxidative stress and membrane damage, hypoxic regulation of blood flow, heat shock proteins in hypoxia, and future directions in hypoxia research. In 2003 we also had the privilege ofhonoring John W. Severinghaus as a friend, colleague, mentor and inspiration to many in the field. Tom Hornbein's personal tribute to John Severinghaus is the first chapter in this volume, followed by an entertaining update of the history of the discovery of oxygen written by John Severinghaus.
Author | : Thuy Tuong Nguyen |
Publisher | : |
Total Pages | : 166 |
Release | : 2016 |
Genre | : Electronic dissertations |
ISBN | : |
Author | : R.C. Cutler |
Publisher | : Birkhäuser |
Total Pages | : 393 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 3034873379 |
Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.
Author | : S. Valentini |
Publisher | : |
Total Pages | : |
Release | : 2011 |
Genre | : |
ISBN | : |
In my thesis I was testing two established ageing theories in C. elegans. One was about the role of oxidative damage, induced via the Fenton reaction, in C. elegans ageing. In my other project I was investigating the role of sirtuins, NAD+- dependent histone deacetylases, in ageing. The oxidative damage theory predicts that reactive oxygen species (ROS) is a main cause of ageing. Iron can generate ROS via the Fenton reaction, indicating that iron homeostasis might protect against aging. Ferritins, iron storage proteins, regulate the iron concentration by storing excess iron. C. elegans has two ferritin genes, ftn-1 and ftn-2. Long-lived daf- 2 mutants show an increase in ftn-1 mRNA levels, indicating that ftn-1 might contribute to longevity assurance. I tested the role of ftn-1 in longevity assurance and found that reduced ftn-1 levels did not affect daf-2 mutant longevity or wildtype life span, nor did over-expression of ftn-1 increase life span. Changing iron levels via ftn-1 over-expression or iron chelator treatment led to resistance to oxidative stress, but had no effect on ageing. Overall, our results show that ferritin does not contribute to longevity assurance, and imply that oxidative damage, induced via the Fenton reaction is not a determinant of aging in C. elegans. Over-expression of sirtuins has been reported to increase life span in yeast, C. elegans and Drosophila. Rumours and contradictory findings caused us to re-test the effects of sirtuin over-expression on ageing. We found that backcrossing the two mainly used sir-2.1 over-expressing strains LG100 and NL3909, to wildtype background abolished the increase in life span, without changing the over-expression of sir-2.1. Reducing sir-2.1 levels had no effect on LG100. Instead, longevity co-segregated with a second-site mutation affecting sensory neurons in LG100. These findings question the role of sirtuins in ageing.
Author | : Mallappa Kumara Swamy |
Publisher | : Springer Nature |
Total Pages | : 619 |
Release | : 2020-05-11 |
Genre | : Science |
ISBN | : 9811517614 |
Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.
Author | : |
Publisher | : World Scientific |
Total Pages | : 750 |
Release | : |
Genre | : |
ISBN | : |