The Role Of Matrix Metalloproteinase In Human Body Pathologies PDF Download
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Author | : Francesco Travascio |
Publisher | : BoD – Books on Demand |
Total Pages | : 202 |
Release | : 2017-12-20 |
Genre | : Medical |
ISBN | : 9535137174 |
Download The Role of Matrix Metalloproteinase in Human Body Pathologies Book in PDF, ePub and Kindle
Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body.
Author | : Francesco Travascio |
Publisher | : |
Total Pages | : 200 |
Release | : 2017 |
Genre | : Genetics |
ISBN | : 9789535140139 |
Download The Role of Matrix Metalloproteinase in Human Body Pathologies Book in PDF, ePub and Kindle
Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body.
Author | : Constance E Brinckerhoff |
Publisher | : World Scientific |
Total Pages | : 295 |
Release | : 2017-05-05 |
Genre | : Science |
ISBN | : 9813207566 |
Download Matrix Metalloproteinases In Health And Disease: Sculpting The Human Body Book in PDF, ePub and Kindle
The biochemistry and cell biology of Matrix Metalloproteinases (MMPs) are not necessarily straightforward, but basic information on the history of these enzymes, their various functions that extend far beyond the cleaving of the extracellular matrix, and the complex mechanisms that control their expression are valuable to both scientists and clinicians. This volume summarizes the salient features and functions of MMPs and applies this information in a practical manner in order to understand how they contribute to normal physiology and pathology of selected diseases. Chapters by noted clinicians Jean-Michel Dayer, MD in rheumatology, Jian Cao, MD in oncology, and Peter Libby, MD in cardiology, represent important practical and clinically-oriented contributions.
Author | : J. F. Woessner |
Publisher | : Oxford University Press on Demand |
Total Pages | : 223 |
Release | : 2000 |
Genre | : Medical |
ISBN | : 9780198502685 |
Download Matrix Metalloproteinases and TIMPs Book in PDF, ePub and Kindle
The matrix metalloproteinases (MMPs) are a large family of enzymes that breakdown different components of the extracellular matrix. Their catalytic activity is dependent a metal ion, usually zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this, is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the 4 known classes of TIMP. Matrix metalloproteinases will therefore be an invaluable source of data for all researchers interested in MMPs and TIMPs.
Author | : Francesco Travascio |
Publisher | : BoD – Books on Demand |
Total Pages | : 376 |
Release | : 2016-06-15 |
Genre | : Science |
ISBN | : 9535124153 |
Download Composition and Function of the Extracellular Matrix in the Human Body Book in PDF, ePub and Kindle
The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.
Author | : William C. Parks |
Publisher | : Springer Science & Business Media |
Total Pages | : 262 |
Release | : 2011-04-07 |
Genre | : Science |
ISBN | : 3642168612 |
Download Extracellular Matrix Degradation Book in PDF, ePub and Kindle
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Author | : Neil J. Clendeninn |
Publisher | : Springer Science & Business Media |
Total Pages | : 371 |
Release | : 2000-09-17 |
Genre | : Medical |
ISBN | : 159259011X |
Download Matrix Metalloproteinase Inhibitors in Cancer Therapy Book in PDF, ePub and Kindle
Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.
Author | : Raffaele Serra |
Publisher | : |
Total Pages | : 196 |
Release | : 2020-09-11 |
Genre | : |
ISBN | : 9783039430529 |
Download Matrix Metalloproteinases in Health and Disease Book in PDF, ePub and Kindle
Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual's disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems.
Author | : Sajal Chakraborti |
Publisher | : Springer |
Total Pages | : 516 |
Release | : 2017-07-13 |
Genre | : Medical |
ISBN | : 9811031622 |
Download Proteases in Human Diseases Book in PDF, ePub and Kindle
This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Author | : Cai Huang |
Publisher | : BoD – Books on Demand |
Total Pages | : 482 |
Release | : 2012-09-06 |
Genre | : Medical |
ISBN | : 9535107372 |
Download Protein Phosphorylation in Human Health Book in PDF, ePub and Kindle
15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.