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| Author | : Brian P. Head |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2005 |
| Genre | : |
| ISBN | : |
| Author | : Alexey V. Glukhov |
| Publisher | : Frontiers Media SA |
| Total Pages | : 212 |
| Release | : 2020-07-08 |
| Genre | : |
| ISBN | : 2889638367 |
| Author | : |
| Publisher | : |
| Total Pages | : 71 |
| Release | : 1927 |
| Genre | : |
| ISBN | : 9789957117955 |
| Author | : Viacheslav Nikolaev |
| Publisher | : Springer |
| Total Pages | : 383 |
| Release | : 2017-09-19 |
| Genre | : Medical |
| ISBN | : 3319545795 |
The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.
| Author | : Andrew L. Clark |
| Publisher | : Oxford University Press |
| Total Pages | : 897 |
| Release | : 2022 |
| Genre | : Medical |
| ISBN | : 019876622X |
Taking the reader from an understanding of the basic mechanisms of heart failure through to an appreciation of the complexities of heart failure management and the remarkable improvements possible with good treatment, the Oxford Textbook of Heart Failure 2e covers all aspects necessary to manage a patient with heart failure. In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last two decades, the textbook also includes extensive chapters on common co-morbidities. The new edition has been completely updated in line with new British and European Guidelines and contains new chapters on; Natriuretic Peptides and Novel Biomarkers in Heart Failure, The Future of Heart Failure, and Regenerative Therapies. Essential reading for consultant cardiologists and those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses.
| Author | : Thomas Brand |
| Publisher | : MDPI |
| Total Pages | : 307 |
| Release | : 2018-07-10 |
| Genre | : Medical |
| ISBN | : 3038429899 |
This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD
| Author | : José Marín-García |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 511 |
| Release | : 2011-06-21 |
| Genre | : Medical |
| ISBN | : 1441994610 |
Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.
| Author | : José Marín-García |
| Publisher | : Academic Press |
| Total Pages | : 935 |
| Release | : 2014-05-09 |
| Genre | : Medical |
| ISBN | : 0124046428 |
In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
| Author | : Christopher J. Fielding |
| Publisher | : John Wiley & Sons |
| Total Pages | : 294 |
| Release | : 2006-12-13 |
| Genre | : Science |
| ISBN | : 3527607501 |
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
| Author | : Ihor Gussak |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 549 |
| Release | : 2003-03-13 |
| Genre | : Medical |
| ISBN | : 1592593623 |
A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.
