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| Author | : Charles B. Carpenter |
| Publisher | : |
| Total Pages | : 77 |
| Release | : 1989 |
| Genre | : |
| ISBN | : |
| Author | : Lucienne Chatenoud |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 198 |
| Release | : 2013-11-22 |
| Genre | : Medical |
| ISBN | : 3662221950 |
Experimental and clinical evidence presented in this book illustrates that antibodies expressing different specificities can be very effective in preventing or reversing established transplant rejection. Moreover, the data leads us to hope that the use of these new therapeutic agents may allow the induction of specific tolerance to transplant alloantigens which is the only means to avoid the major risks of sustained immunosuppression, namely an increased susceptibility to infection and tumor development. In this volume the editors combine contributions dealing with very practical aspects of the clinical use of monoclonal antibodies with a more general discussion on the developments one may foresee in the near future.
| Author | : William J. Burlingham |
| Publisher | : CRC Press |
| Total Pages | : 154 |
| Release | : 1991-12-18 |
| Genre | : Medical |
| ISBN | : 9780849368219 |
Critical Analysis of Monoclonal Antibody Therapy in Transplantation provides a critical analysis of monoclonal antibody therapies in transplantation. The book presents diverse approaches to monoclonal antibody therapy in transplantation and addresses some of the serious obstacles that remain both in understanding these mechanisms and in successfully applying them in clinical situations. The background and rationale for OKT3 therapy are examined and an extensive clinical experience with OKT3 induction therapy in cardiac transplantation is reviewed. The book also examines the background and rationale for the use of anti-TcR (??), anti-IL-2R, and anti-LFA-1 monoclonal antibodies in clinical transplantations. Other topics include the use of monclonal antibodies to CD4 and CD8 for the induction of adult transplantation tolerance in rodents and the possibilities for applying anti-idiotypical strategies that have proven useful in autoimmunity models to transplant recipients. Researchers and basic scientists involved in this field will find the book a fascinating and useful resource for their investigations.
| Author | : Lucienne Chatenoud |
| Publisher | : |
| Total Pages | : 208 |
| Release | : 2014-09-01 |
| Genre | : |
| ISBN | : 9783662221969 |
| Author | : Angus W. Thomson |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 534 |
| Release | : 2001 |
| Genre | : Medical |
| ISBN | : 9780792368892 |
This work has broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (for example, rheumatoid arthritis), skin disease and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area.
| Author | : Stefan Dübel |
| Publisher | : John Wiley & Sons |
| Total Pages | : 2538 |
| Release | : 2014-08-04 |
| Genre | : Science |
| ISBN | : 3527682449 |
Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.
| Author | : Stuart J. Knechtle |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 752 |
| Release | : 2019-08-31 |
| Genre | : Medical |
| ISBN | : 0323547966 |
Offering practical guidance for all members of the transplant team, Kidney Transplantation, Principles and Practice, 8th Edition, provides the balanced, up-to-date information you need to achieve optimal outcomes for your patients. A global team of internationally renowned surgeons and nephrologists, many new to this edition, offers fresh perspectives on everything from applied science and surgical techniques to immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, in both adults and children. Offers state-of-the-art coverage of all areas of kidney transplantation such as preservation of kidneys; mechanisms of rejection and the induction of tolerance; techniques of laparoscopic live donor nephrectomy; and immunosuppression. Contains up-to-date outcomes data and analysis of the evidence supporting current practice in the field. Includes new information on desensitization and considerable new data on the clinical use of costimulation blockade. Keeps you current with new chapters on kidney allocation policy that reflects the ethical and societal values of different countries and populations; and biomarkers of kidney injury and rejection, including the need for better monitoring tools to guide therapy and patient management. Covers hot topics such as management of chronic allograft failure, the sensitized patient and antibody-mediated rejection, and paired exchange principles. Features hundreds of superb illustrations to help you visualize key concepts and nuances of renal transplantation. Provides dynamic visual guidance with new real-time video coverage of ultrasound-guided pancreas allograft biopsy; a new animation of calcineurin inhibitor mechanism of action animation; and videos that demonstrate the formation of an immune synapse, 3-D rotational images of immune synapses, an NK cell killing its target, peritoneal dialysis-catheter insertion techniques, laparoendoscopic single site (LESS) donor nephrectomy, and more.
| Author | : Charat Thongprayoon |
| Publisher | : |
| Total Pages | : 270 |
| Release | : 2020-09-10 |
| Genre | : |
| ISBN | : 9783039364077 |
Advances in immunosuppression and kidney transplant techniques have led to significant improvements in the short-term survival of the renal allograft. Long-term graft survival, however, has relatively lagged behind and has now become one of the main problems in kidney transplantation. In this Special Issue, we discuss the recent research developments in kidney transplants that may affect long-term allografts, as well as the survival of the patient. The latest developments in living kidney donation are also explored.
| Author | : Robert W Maitta |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 380 |
| Release | : 2019-08-27 |
| Genre | : Medical |
| ISBN | : 0323675107 |
Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.
| Author | : Wadi N. Suki |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1258 |
| Release | : 2013-06-29 |
| Genre | : Medical |
| ISBN | : 1475766327 |
The field of renal disease has witnessed a huge increase in new knowledge in the 1990s. Advances in our understanding of the pathogenesis and treatment of this complex group of disorders have been escalating rapidly. This is a third edition of this book, which is intended to provide the physician with a clear, comprehensive text on the management of the diverse array of disorders of fluids and electrolytes, of acid-base and mineral metabolism, and of renal structure and function.
