The Neurobiology Of Multiple Sclerosis PDF Download
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| Author | : Stephen Waxman |
| Publisher | : Elsevier |
| Total Pages | : 495 |
| Release | : 2005-05-27 |
| Genre | : Medical |
| ISBN | : 0080489419 |
Download Multiple Sclerosis As A Neuronal Disease Book in PDF, ePub and Kindle
This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis* Places MS in a new and important perspective that promises to open up new therapeutic avenues* Superbly illustrated and referenced
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 759 |
| Release | : 2007-06-07 |
| Genre | : Science |
| ISBN | : 0080544274 |
Download The Neurobiology of Multiple Sclerosis Book in PDF, ePub and Kindle
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the “cause and the “cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 457 |
| Release | : 2001-08-10 |
| Genre | : Medical |
| ISBN | : 0309072859 |
Download Multiple Sclerosis Book in PDF, ePub and Kindle
Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
| Author | : Ian D. Duncan |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 296 |
| Release | : 2012-08-31 |
| Genre | : Medical |
| ISBN | : 1461422183 |
Download Myelin Repair and Neuroprotection in Multiple Sclerosis Book in PDF, ePub and Kindle
Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier. Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients.
| Author | : Alastair Compston |
| Publisher | : |
| Total Pages | : 620 |
| Release | : 1998 |
| Genre | : Medical |
| ISBN | : |
Download McAlpine's Multiple Sclerosis Book in PDF, ePub and Kindle
This is the latest edition of the classic book on the subject of multiple sclerosis. An international group of authors has been involved in updating this edition which features more information on imaging and investigations, and a new chapter on neurobiology and glial development.
| Author | : Barbara S. Giesser |
| Publisher | : Oxford University Press |
| Total Pages | : 613 |
| Release | : 2016-01-29 |
| Genre | : Medical |
| ISBN | : 0199341028 |
Download Primer on Multiple Sclerosis Book in PDF, ePub and Kindle
Primer on Multiple Sclerosis, 2nd Edition is an updated reference manual for the practicing clinician. It covers the range of information needed to treat persons with MS, beginning with basic science and immunopathology, thorough differential diagnosis, symptom management and disease modifying therapies. This essential book also includes material covering new and experimental strategies as well as a review of commonly used complementary and alternative modalities that are used by persons with MS.Multiple Sclerosis (MS) is the most common demyelinating disease of the CNS and the third most common cause of disability among young adults. The complex management issues that are often present in the care of individuals with MS may demand the participation of health care professionals from a variety of disciplines, although the team is usually led by a neurologist. It is therefore essential for the neurologist to have a thorough grounding in the basic science and clinical phenomenology of MS. In this second edition of Primer on Multiple Sclerosis, the latest updates on therapeutics are provided, including new medications that have been FDA- approved since the first edition. Includes new diagnostic criteria, as well as any advances made in current diagnostic techniques, e.g. new imaging metrics. Important new information in the basic sciences and pathophysiology of MS is provided as well as newer epidemiologic studies. Treatment algorithms for common symptoms will be expanded, as well as any new guidelines for switching medications for Disease Modifying treatment "failures". The chapter on alternative and complimentary therapies discusses new research on CCSVI. The chapter on legal issues includes information on the putative effect of the Affordable Health Care Act on access to neurologic care and treatments. Finally, there is expanded discussion of progressive forms of MS both from a basic science and treatment perspective.
| Author | : Seung U. Kim |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 276 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1461307775 |
Download Myelination and Demyelination Book in PDF, ePub and Kindle
In June 1987, neurobiologists, immunologists, molecular biologists, virologists and neurologists from several countries met in Vancouver to discuss recent advances of relevance to multiple sclerosis. The symposium was a part of the 22nd Canadian Congress of Neurological Sciences meeting and was sponsored by funds from the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada. The presentations covered five major topics: basic neurobiology, molecular biology, the role of viruses in demyelination, immune function and dysfunction in multiple sclerosis, and clinical magnetic resonance imaging studies. It was heartening to note that scientists from several different disciplines were working towards a common end-point: the understanding and treatment of multiple sclerosis. In this book, speakers at the symposium have each presented a chapter of their findings and discussions. In addition, some non-participants at the symposium have been invited to submit chapters in order to give this volume a more complete scope. It is hoped that the reader will find this book a useful reference for several subjects of interest to multiple sclerosis. In closing, I would like to thank the following for their help and support: the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada for their financial support; the contributors of this book for their manuscripts; Dr. A. Eisen, Mrs. K. Eisen, Mrs. P. Bodnarchuk and Mrs. M. Kim for their efforts in planning and organizing the symposium; and Ms. Catherine Schikowski for her secretarial assistance. Seung U. Kim, M.D. Ph.D.
| Author | : Howard L. Weiner, M.D. |
| Publisher | : Harmony |
| Total Pages | : 354 |
| Release | : 2007-12-18 |
| Genre | : Health & Fitness |
| ISBN | : 0307420523 |
Download Curing MS Book in PDF, ePub and Kindle
What causes multiple sclerosis? When will there be a cure? Dr. Howard Weiner has spent nearly three decades trying to find answers to the mysteries of multiple sclerosis, an utterly confounding and debilitating disease that afflicts almost half a million Americans. Curing MS is his moving, personal account of the long-term scientific quest to pinpoint the origins of the disease and to find a breakthrough treatment for its victims. Dr. Weiner has been at the cutting edge of MS research and drug development, and he describes in clear and illuminating detail the science behind the symptoms and how new drugs may hold the key to "taming the monster." From the "Twenty-one Points" of MS--a concise breakdown of the knowns and unknowns of the disease--to stories from the frontlines of laboratories and hospitals, Curing MS offers a message of hope about new treatments and makes a powerful argument that a cure can--and will--be found.
| Author | : Stephen Waxman |
| Publisher | : Elsevier |
| Total Pages | : 549 |
| Release | : 2004-11-05 |
| Genre | : Medical |
| ISBN | : 0080506984 |
Download From Neuroscience to Neurology Book in PDF, ePub and Kindle
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work* Explores the future of this field
| Author | : Moses Rodriguez |
| Publisher | : Oxford University Press |
| Total Pages | : 216 |
| Release | : 2013-05-17 |
| Genre | : Medical |
| ISBN | : 019997019X |
Download Multiple Sclerosis Book in PDF, ePub and Kindle
This latest edition to the 'Contemporary Neurology Series' will fill one of the few remaining 'neurologic gaps' within the Series. 'Multiple Sclerosis,' written solely by Moses Rodriguez, Orhun Kantarci and Istvan Pirko of the Mayo Clinic in Rochester, MN will offer proven, effective treatments for specific presentations and symptoms of multiple sclerosis along with a pathophysiological explanation of why they work. It bridges a needed gap between overly simplistic therapy manuals and basic science texts that discuss human disease only insofar as it mimics what is observed in animal models of the disease in the laboratory. Additionally, it seeks to offer an efficient integrative approach to symptomatic treatment to avoid over-medication and side effects. It discusses the heterogeneous causes of the disease and the need to develop individualized treatments that address the basic pathophysiologic processes that characterize each patient's disease with the future goal of individualized medicine. 'Multiple Sclerosis' covers both the basic research aspects of MS: epidemiology, neuropathology, genetics, and immunology as well as the treatment options associated with the MS patient: sleep, steroids, pharma, neuropsychology, and growth factors (to name a few). 'Multiple Sclerosis' will focus on the medical treatment - drug treatment - of MS rather than on physical medicine and rehabilitation (not the author's strength). The authors will also make ample use of flow diagrams, bulleted points, and tables to help the reader better understand MS and its etiology and treatment.
