The Molecular Biology Of Neurological Disease PDF Download
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| Author | : Roger N. Rosenberg |
| Publisher | : Butterworth-Heinemann |
| Total Pages | : 277 |
| Release | : 2013-10-22 |
| Genre | : Medical |
| ISBN | : 148316330X |
Download The Molecular Biology of Neurological Disease Book in PDF, ePub and Kindle
The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.
| Author | : David B. Teplow |
| Publisher | : Academic Press |
| Total Pages | : 499 |
| Release | : 2012-04-13 |
| Genre | : Medical |
| ISBN | : 0123858836 |
Download Molecular Biology of Neurodegenerative Diseases Book in PDF, ePub and Kindle
Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson's, Alzheimer's and Huntington's disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field
| Author | : Roger N. Rosenberg |
| Publisher | : Butterworth-Heinemann |
| Total Pages | : 1054 |
| Release | : 1993 |
| Genre | : Medical |
| ISBN | : |
Download The Molecular and Genetic Basis of Neurological Disease Book in PDF, ePub and Kindle
| Author | : Stephen Waxman |
| Publisher | : Elsevier |
| Total Pages | : 597 |
| Release | : 2010-07-26 |
| Genre | : Medical |
| ISBN | : 0080546188 |
Download Molecular Neurology Book in PDF, ePub and Kindle
Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments
| Author | : Dieter B. Wildenauer |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 303 |
| Release | : 2008-11-28 |
| Genre | : Science |
| ISBN | : 3540853839 |
Download Molecular Biology of Neuropsychiatric Disorders Book in PDF, ePub and Kindle
It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.
| Author | : Sunil Kumar |
| Publisher | : Academic Press |
| Total Pages | : 178 |
| Release | : 2021-02-16 |
| Genre | : Medical |
| ISBN | : 0128232544 |
Download The Molecular Immunology of Neurological Diseases Book in PDF, ePub and Kindle
The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches. Discusses the molecular immunogenetics of different neurological diseases Covers strategies for the development of therapeutic approaches Encompasses both acute and chronic neurogenerative disorders Describes the molecular pathogenesis of viral genes in various diseases Features chapters on migraine, muscular dystrophy and cancer
| Author | : Daniela Tropea |
| Publisher | : Frontiers Media SA |
| Total Pages | : 586 |
| Release | : 2018-01-31 |
| Genre | : |
| ISBN | : 2889453804 |
Download Biology of Brain Disorders Book in PDF, ePub and Kindle
Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future. In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.
| Author | : Fredric P. Manfredsson |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2015-11-26 |
| Genre | : Medical |
| ISBN | : 9781493932702 |
Download Gene Therapy for Neurological Disorders Book in PDF, ePub and Kindle
This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.
| Author | : Patrick A. Lewis |
| Publisher | : Academic Press |
| Total Pages | : 274 |
| Release | : 2018-11-16 |
| Genre | : Science |
| ISBN | : 0128110708 |
Download The Molecular and Clinical Pathology of Neurodegenerative Disease Book in PDF, ePub and Kindle
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
| Author | : Roger N. Rosenberg |
| Publisher | : Butterworth-Heinemann |
| Total Pages | : 898 |
| Release | : 2003 |
| Genre | : Medical |
| ISBN | : |
Download The Molecular and Genetic Basis of Neurologic and Psychiatric Disease Book in PDF, ePub and Kindle
Inside the third edition of this reference, the reader will find thorough and authoritative discussions of all of these developments and their implications for clinical practice. It includes a major new section on Psychiatric Diseases; descriptions of the molecular and genetic basis of the spongiform encephalopathies as well as the expression of the prion gene under physiologic and pathologic conditions; additional coverage examines the human genome project and neurologic disease; and coverage on alzheimer's disease and related dementias.
