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| Author | : A. M. L. Lever |
| Publisher | : |
| Total Pages | : 240 |
| Release | : 1996-05-07 |
| Genre | : Medical |
| ISBN | : |
This study, based on both clinical and molecular trials, outlines the principles of the molecular biology of HIV and AIDS. Topics such as the origins of the virus, viral interactions with the immune system, antiviral intervention and vaccine prospects are covered.
| Author | : Ajit Kumar |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 355 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1468459287 |
Since the discovery of HIV-l as the etiologic agent of acquired immunodeficiency syndrome (AIDS) in the early 1980s, remarkable progress has been made in both the basic understanding of the biological processes leading to AIDS and an accelerated effort in finding new treatments. As is often the case in rapidly advancing fields, most of the scientific discussions are best handled in specialized groups. The effort to organize a meeting on advances in molecular biology and targeted treatment for AIDS was an experiment of sorts to gather experts in selected areas of overlapping interests where advances in basic biology and its application in the development of new drugs could be discussed. Of necessity, the scope of the meeting had to be limited to maintain a certain focus. Important areas of rapid development in AIDS research, such as the vaccine development, epidemiology, animal models, etc. , had to be left out for more specialized meetings. The result, from all accounts, appeared to be quite a successful gathering, which provided a forum for informal discussions among scientists from industry and academic institutions. A remarkable feature of the AIDS virus is its genetic complexity and how some of its seemingly "extra genes" manage to regulate the normal functions of the host and most importantly its immune system.
| Author | : Nelson Michael |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 402 |
| Release | : 2008-02-01 |
| Genre | : Medical |
| ISBN | : 1592596010 |
The worldwide impact of infection with human immunodeficiency virus type 1 (HIV- is reflected in the cumulative number ofHIV- 1 infections, which is now predicted to exceed 40 million by the year 2000---equivalent to the n- ber of humans who perished in World War II. The medical and scientific - sponse to the HIV-1 pandemic has steadily grown since its recognition in 1981. The outlay by the United States alone for HIV research funded by the National Institutes of Health in 1997 was $1. 4 billion. Laboratory-based HIV research has brought together academic clinicians, retrovirologists, molecular biologists, and immunologists in the formation of research teams attempting to dissect the viral and host factors contributing to disease pathogenesis. Increasing focus is being placed on those aspects of viral biology and host immune responses that bear on the development of vaccines to prevent HIV infection. HIVProtocols reflects the state of HIV research in several ways. First, chapters are organized into four sections: Virology, Molecular Biology, Humoral Immunology, and Cellular Immunology. This organization is a natural consequence of the diverse scientific disciplines that have been attracted to HIV research. Second, the chapters reflect such diverse research directions as viral coreceptor usage, quantitation of viral genomes, HIV promoter function, B-cell epitope mapping, and measurements of T-cell function, each of which bears on the goal of understanding the viral and host immune responses that will be critical to the design of effective preventive vaccines.
| Author | : S. Myint |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 290 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9401115303 |
Human immunodeficiency virus and AIDS have received much attention in the last decade. As the major cause of death in young adults, this concern is merited. AIDS has also ushered onto the clinical agenda a number of unusual and interesting pathogens. These have had considerably less attention than the virus itself, but are arguably as important. This book attempts to put into one volume a state of the art review of the basic biology of these opportunistic organisms. When compiling this book, the perceived difficulty was deciding how to restrict the number of chapters, as there is a large number of opportunistic organisms. It soon became clear, however, that the chapters would select themselves, as the work on many of these organisms was still in its infancy. We can be criticized for including Salmonella, which is not thought to be an opportunistic infection, and excluding Cryptococcus. Our defence is that the former has an interesting relationship with HIV and the latter is one of those organisms for which the basic biology is still in its early stages. The authors are all active researchers in their respective fields and we are grateful that they managed to review their subjects in the short turn-around time required for a book such as this not to be needlessly outdated on publication. We hope that, if nothing else, this book stimulates interest and more research on these agents: perhaps, in future editions, there will be much more to describe on their molecular biology.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 561 |
| Release | : 2000-09-26 |
| Genre | : Medical |
| ISBN | : 0080549861 |
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines. The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Detailed insights into viral packaging, expression, and assembly Mechanistic understanding of how HIV interacts with receptors and infects cells Delineation of virally encoded regulatory processes unique to HIV Clinical Applications: An updated review of current chemotherapeutics for HIV New concepts in the discovery and design of novel anti-HIV drugs The latest developments in HIV-vaccine research
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 524 |
| Release | : 2000-09-07 |
| Genre | : Science |
| ISBN | : 0080553923 |
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Detailed insights into viral packaging, expression, and assembly Mechanistic understanding of how HIV interacts with receptors and infects cells Delineation of virally encoded regulatory processes unique to HIV Clinical Applications: An updated review of current chemotherapeutics for HIV New concepts in the discovery and design of novel anti-HIV drugs The latest developments in HIV-vaccine research
| Author | : Eric O. Freed |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 229 |
| Release | : 2013-07-12 |
| Genre | : Medical |
| ISBN | : 1461477298 |
Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 488 |
| Release | : 2007-06-27 |
| Genre | : Medical |
| ISBN | : 9780123736109 |
This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.
| Author | : Dr. Taussig |
| Publisher | : |
| Total Pages | : 88 |
| Release | : 1997 |
| Genre | : AIDS (Disease) |
| ISBN | : |
| Author | : Anna Aldovini |
| Publisher | : Springer |
| Total Pages | : 277 |
| Release | : 1990-06-18 |
| Genre | : Medical |
| ISBN | : 1349118885 |
A comprehensive compilation of research techniques necessary for investigating the virology, immunology and molecular biology of HIV-1. Protocols are also provided which represent state of the art approaches to a wide spectrum of HIV related issues.
