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The Mitochondrion in Aging and Disease

The Mitochondrion in Aging and Disease
Author:
Publisher: Academic Press
Total Pages: 300
Release: 2014-08-19
Genre: Science
ISBN: 0123948401

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Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed. Reviews current topics of interest Written by experts in the field


Mitochondrial Dysfunction in Aging and Diseases of Aging

Mitochondrial Dysfunction in Aging and Diseases of Aging
Author: Richard H. Haas
Publisher: MDPI
Total Pages: 268
Release: 2019-10-01
Genre: Science
ISBN: 303921327X

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This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.


Mitochondrial Dysfunction in Ageing and Diseases

Mitochondrial Dysfunction in Ageing and Diseases
Author: Jaime M. Ross
Publisher: MDPI
Total Pages: 543
Release: 2018-09-28
Genre: Electronic book
ISBN: 3038422517

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This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS


Mitochondrial Dysfunction

Mitochondrial Dysfunction
Author: Lawrence H. Lash
Publisher: Elsevier
Total Pages: 527
Release: 2013-10-22
Genre: Science
ISBN: 1483218619

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Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.


Understanding the Process of Aging

Understanding the Process of Aging
Author: Lester Packer
Publisher: CRC Press
Total Pages: 384
Release: 1999-01-12
Genre: Medical
ISBN: 1482292947

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This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the researc


Mitochondrial Dysfunction in Aging and Diseases of Aging

Mitochondrial Dysfunction in Aging and Diseases of Aging
Author: Richard H. Haas
Publisher:
Total Pages: 1
Release: 2019
Genre: Electronic books
ISBN: 9783039213283

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This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.


Mitochondria and the Future of Medicine

Mitochondria and the Future of Medicine
Author: Lee Know
Publisher: Chelsea Green Publishing
Total Pages: 274
Release: 2018
Genre: Health & Fitness
ISBN: 1603587675

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With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.


Mitochondria Dysfunction

Mitochondria Dysfunction
Author: Tailor Fran
Publisher: Independently Published
Total Pages: 0
Release: 2024-02-12
Genre: Self-Help
ISBN:

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Attention: We all age, and with it comes a decline in health. But have you ever considered the tiny powerhouses lurking inside your cells, playing a pivotal role in this process? 'Mitochondria dysfunction: The unexpected roles of Mitochondria in Aging and Diseases' delves into the fascinating and often surprising world of these cellular power plants, revealing their profound impact on your health and longevity. Interest: Imagine mitochondria as tiny factories fueled by oxygen and nutrients, generating the energy that keeps your body ticking. But what happens when these factories malfunction? This book unveils the unexpected ways in which mitochondrial dysfunction contributes to not just aging, but also a spectrum of diseases, from neurodegenerative disorders like Alzheimer's and Parkinson's to chronic conditions like heart disease and diabetes. Desire: This isn't just a scientific exploration; it's a guide to understanding your own health. You'll discover the latest research on how lifestyle choices, diet, and even exercise can influence mitochondrial function, potentially slowing down the aging process and reducing your risk of disease. The book empowers you to become an active participant in your own well-being, offering evidence-based strategies for optimizing your cellular powerhouses. Action: Forget fad diets and quick fixes. This book equips you with the knowledge to make informed decisions about your health. You'll learn about cutting-edge research in areas like mitochondrial-targeted therapies, offering a glimpse into the future of personalized medicine focused on rejuvenating your cellular powerhouses. 'More than just understanding aging and disease, this book empowers you to take control of your health and unlock the potential for a longer, healthier life.'


The Role of Mitochondria in Human Aging and Disease

The Role of Mitochondria in Human Aging and Disease
Author: Yau-Huei Wei
Publisher: Wiley-Blackwell
Total Pages: 556
Release: 2006-08-04
Genre: Science
ISBN: 9781573315425

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Virtually every aspect of mitochondrial research and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.


Mitochondria in Health and Diseases

Mitochondria in Health and Diseases
Author: Sabzali Javadov
Publisher:
Total Pages: 434
Release: 2020-09-04
Genre:
ISBN: 9783039363841

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Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.