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Pain Management and the Opioid Epidemic

Pain Management and the Opioid Epidemic
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 483
Release: 2017-09-28
Genre: Medical
ISBN: 0309459575

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Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.


Medications for Opioid Use Disorder Save Lives

Medications for Opioid Use Disorder Save Lives
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 175
Release: 2019-06-16
Genre: Medical
ISBN: 0309486483

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The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.


Federal Regulation of Methadone Treatment

Federal Regulation of Methadone Treatment
Author: Committee on Federal Regulation of Methadone Treatment
Publisher: National Academies Press
Total Pages: 251
Release: 1995-02-01
Genre: Medical
ISBN: 0309598621

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For nearly three decades, methadone hydrochloride has been the primary means of treating opiate addiction. Today, about 115,000 people receive such treatment, and thousands more have benefited from it in the past. Even though methadone's effectiveness has been well established, its use remains controversial, a fact reflected by the extensive regulation of its manufacturing, labeling, distribution, and use. The Food and Drug Administration regulates the safety and effectiveness of methadone, as it does for all drugs, and the Drug Enforcement Administration regulates it as a controlled substance. However, methadone is also subjected to a unique additional tier of regulation that prescribes how and under what circumstances it may be used to treat opiate addiction. Federal Regulation of Methadone Treatment examines current Department of Health and Human Services standards for narcotic addiction treatment and the regulation of methadone treatment programs pursuant to those standards. The book includes an evaluation of the effect of federal regulations on the provision of methadone treatment services and an exploration of options for modifying the regulations to allow optimal clinical practice. The volume also includes an assessment of alternatives to the existing regulations.


Pain Modulation

Pain Modulation
Author: Howard L. Fields
Publisher: Elsevier Publishing Company
Total Pages: 454
Release: 1988-01-01
Genre: Medical
ISBN: 9780444809841

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This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.


Prescription of Narcotics for Heroin Addicts

Prescription of Narcotics for Heroin Addicts
Author: Ambros Uchtenhagen
Publisher: S. Karger AG (Switzerland)
Total Pages: 152
Release: 1999
Genre: Medical
ISBN:

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This is the first volume of the long-awaited research report on a much discussed study on the prescription of heroin and other narcotics to chronic heroin addicts in Switzerland. Data were collected over a period of 3 years on a cohort of 1,035 chronic heroin addicts who had failed in drug-free or methadone substitution treatments and who were prescribed heroin, morphine or methadone within the framework of a comprehensive care program. According to the findings of the study, heroin maintenance is considered to have a positive effect on both patients and their social environment due to an improvement in health and social status of the patients as well as a significant decrease in drug-related delinquency. This report provides a unique source of information on pharmacological, medical and psychosocial aspects of heroin maintenance. It is indispensable reading for psychiatrists, doctors, and social workers working with drug addicts as well as for pharmacologists, social scientists, criminologists and public health officials concerned with the treatment and management of drug addiction.


Understanding Prescription Drugs For Canadians For Dummies

Understanding Prescription Drugs For Canadians For Dummies
Author: Ian Blumer
Publisher: John Wiley & Sons
Total Pages: 511
Release: 2009-08-26
Genre: Medical
ISBN: 0470677058

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The ultimate Canadian guide to prescription medication Over half of all Canadians take at least one prescription drug, but most of us know very little about the medication we're taking, including why we've been prescribed anything in the first place. Understanding Prescription Drugs Canadians For Dummies will answer many of the questions Canadians have about prescription drugs, but were afraid ask our doctors and pharmacists. Topics covered include: * What a prescription drug is * Common concerns * Side effects * Ailments and drugs used to treat them * Prescribing practices Understanding Prescription Drugs For Canadians For Dummies will go beyond the encyclopedic and often overwhelming information offered in massive pill books on the Web. It will empower readers, providing them with the knowledge they need as responsible consumers.


The Medical Prescription of Narcotics

The Medical Prescription of Narcotics
Author: David C. Lewis
Publisher: Seattle ; Toronto : Hogrefe & Huber Pub.
Total Pages: 348
Release: 1997
Genre: Medical
ISBN:

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Presents selected experiences with medical prescription of narcotics, focusing on a Swiss experiment and reporting on experiences in other countries, including the US, Germany, Great Britain, Australia, and The Netherlands. Part I examines the development of medical prescription of narcotics in Switzerland, with perspectives on scientific considerations, ethical and legal aspects, and attitudes of drug users and their parents. Part II reports on drug policy and treatment in other countries, and Part III discusses new developments in pharmacology and therapy. Includes a research plan and implementation guidelines for trials involving the medical prescription of narcotics. Annotation copyrighted by Book News, Inc., Portland, OR


Drug Dealer, MD

Drug Dealer, MD
Author: Anna Lembke
Publisher: JHU Press
Total Pages: 187
Release: 2016-11-15
Genre: Medical
ISBN: 1421421402

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The disturbing connection between well-meaning physicians and the prescription drug epidemic. Three out of four people addicted to heroin probably started on a prescription opioid, according to the director of the Centers for Disease Control and Prevention. In the United States alone, 16,000 people die each year as a result of prescription opioid overdose. But perhaps the most frightening aspect of the prescription drug epidemic is that it’s built on well-meaning doctors treating patients with real problems. In Drug Dealer, MD, Dr. Anna Lembke uncovers the unseen forces driving opioid addiction nationwide. Combining case studies from her own practice with vital statistics drawn from public policy, cultural anthropology, and neuroscience, she explores the complex relationship between doctors and patients, the science of addiction, and the barriers to successfully addressing drug dependence and addiction. Even when addiction is recognized by doctors and their patients, she argues, many doctors don’t know how to treat it, connections to treatment are lacking, and insurance companies won’t pay for rehab. Full of extensive interviews—with health care providers, pharmacists, social workers, hospital administrators, insurance company executives, journalists, economists, advocates, and patients and their families—Drug Dealer, MD, is for anyone whose life has been touched in some way by addiction to prescription drugs. Dr. Lembke gives voice to the millions of Americans struggling with prescription drugs while singling out the real culprits behind the rise in opioid addiction: cultural narratives that promote pills as quick fixes, pharmaceutical corporations in cahoots with organized medicine, and a new medical bureaucracy focused on the bottom line that favors pills, procedures, and patient satisfaction over wellness. Dr. Lembke concludes that the prescription drug epidemic is a symptom of a faltering health care system, the solution for which lies in rethinking how health care is delivered.


Pain Killer

Pain Killer
Author: Barry Meier
Publisher: Rodale
Total Pages: 348
Release: 2003-10-17
Genre: Medical
ISBN: 9781579546380

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Examines OxyContin, the so-called miracle prescription drug that swept the nation but led to overdoes and addiction, providing a look at the multi-billion-dollar pain managment business, its excesses and its abuses.


The Delta Receptor

The Delta Receptor
Author: Kwen-Jen Chang
Publisher: CRC Press
Total Pages: 522
Release: 2003-12-11
Genre: Science
ISBN: 0824758587

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The Delta Receptor spans current research in delta receptor biology, pharmacology, physiology, and chemistry to identify, advance, and inspire the development of novel drug candidates. It demonstrates the potential significance and impact of the delta receptor in the therapy and treatment of medical conditions such as pain, gastrointestinal disorders, bladder dysfunction, and depression, as well as heart attack prevention. This reference examines the pathophysiological functions and mechanisms of receptor-selective drugs. Documenting key advances in the field, The Delta Receptor represents the most comprehensive and up-to-date studies on receptor applications currently available.