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Maternal Control of Development in Vertebrates

Maternal Control of Development in Vertebrates
Author: Florence Louise Marlow
Publisher: Morgan & Claypool Publishers
Total Pages: 221
Release: 2010
Genre: Family & Relationships
ISBN: 161504051X
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Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References

The Maternal-to-Zygotic Transition

The Maternal-to-Zygotic Transition
Author:
Publisher: Academic Press
Total Pages: 449
Release: 2015-09-14
Genre: Science
ISBN: 0124166121
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The Maternal-to-Zygotic Transition provides users with an expert accounting of the mechanisms and functions of this transition in a range of animal and plant models. The book provides critical information on how maternal gene products program the initial development of all animal and plant embryos, then undergoing a series of events, termed the maternal-to-zygotic transition, during which maternal products are cleared and zygotic genome activation takes over the developmental control. Maternal gene products program the initial development of all animal and plant embryos These then undergo a series of events, termed the maternal-to-zygotic transition, during which maternal products are cleared and zygotic genome activation takes over developmental control In this book, experts provide their insights into the mechanisms and functions of this transition in a range of animal and plant models.

Vertebrate Development

Vertebrate Development
Author: Francisco Pelegri
Publisher: Springer
Total Pages: 554
Release: 2016-12-13
Genre: Science
ISBN: 3319460951
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This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.

Gastrulation: From Embryonic Pattern to Form

Gastrulation: From Embryonic Pattern to Form
Author:
Publisher: Academic Press
Total Pages: 478
Release: 2020-01-18
Genre: Science
ISBN: 0128127996
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Gastrulation: From Embryonic Pattern to Form Volume 136 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters on D. melanogaster, Zebrafish, Chick, Mouse and Human, C. elegans, D. melanogaster Internalization, Sea urchin, Ascidians, Xenopus Internalization, Xenopus Convergent Extension, Zebrafish Epiboly, Zebrafish Internalization, Zebrafish Convergence and Extension, Chick Primitive streak formation and mesendoderm internalization, Octavian Voiculescu, Mouse Primitive streak formation and internalization, Mouse Definitive endoderm morphogenesis, Conservation of movements, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on gastrulation from embryonic pattern to form

Gamete and Embryo-fetal Origins of Adult Diseases

Gamete and Embryo-fetal Origins of Adult Diseases
Author: He-Feng Huang
Publisher: Springer Science & Business Media
Total Pages: 229
Release: 2013-11-19
Genre: Health & Fitness
ISBN: 9400777728
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The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians. Editor He-Feng Huang, M.D., is Professor and President of Women’s Hospital, School of Medicine, Zhejiang University, China. Editor Jian-Zhong Sheng, Ph.D., is Professor at the Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, China.

Textbook of Clinical Embryology

Textbook of Clinical Embryology
Author: Kevin Coward
Publisher: Cambridge University Press
Total Pages: 408
Release: 2013-10-31
Genre: Medical
ISBN: 110727625X
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The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.

Oocyte Growth and Maturation

Oocyte Growth and Maturation
Author: T.A. Dettlaff
Publisher: Springer Science & Business Media
Total Pages: 456
Release: 2012-12-06
Genre: Science
ISBN: 1468406825
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Studies of oogenesis occupy an important place in current in vestigations in developmental biology. Today no one has any doubt whatsoever that oogenesis is not just the prelude to development, but is development itself, and a very essential part of it. These words of an eminent Soviet scientist, B. L. As taurov , taken by T. B. Aizenshtadt as an epigraph to her chapter in this book, make a good epigraph for the entire book. It is now clear that during oogenesis not only vast reserves of ribosomes and mitochondria, of yolk, carbohydrates, and lipids, and of enzymes for protein and nucleic acid synthesis and for carbohydrate and fat metabolism (which ensures the energy supply and metabolism of the oocyte and the developing embryo) are formed, but also long-lived mRNA and proteins are synthesized, which determine both the completion of oocyte maturation and the initial stages of embryonic development. In the last 15-20 years, the use of molecular biology methods, electron microscopy, autoradiography, and microsurgical methods of experimental embryology in studying the pre-embryonic development of animals has greatly increased our knowledge of oogenesis. This has led to the need to systematize the data obtained, to reinter pret old ideas, and to review the results obtained by new research trends which have emerged in the last few years and which are of general biological interest. Such a task was undertaken in the book Sovremennye Problemy Oogeneza (Current Problems of Oogenesis), published in 1977 (in Russian).

Fertilization

Fertilization
Author: Brian Dale
Publisher: Cambridge University Press
Total Pages: 149
Release: 2018-09-13
Genre: Medical
ISBN: 1316607895
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Charts the fascinating interaction of specialized gamete cells, forming the early embryo and a blueprint of new life.

Zygotic Genome Activation

Zygotic Genome Activation
Author: Kiho Lee
Publisher: Humana Press
Total Pages: 272
Release: 2017-04-29
Genre: Medical
ISBN: 9781493969869
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This volume provides an overview of zygotic genome activation (ZGA) and the use of recent tools to elucidate the events that occur during ZGA. The chapters in this book cover topics such as: clearance of maternal RNAs, detection of miRNA in mammalian oocytes and embryos, RNA FISH to study ZGA in early mouse embryos, and CRISPR/Cas9-mediated gene targeting during embryogenesis in the mouse and pig. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Zygotic Genome Activation: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about practical approaches to monitor the changes seen during ZGA.

Molecular Methods in Developmental Biology

Molecular Methods in Developmental Biology
Author: Matt Guille
Publisher: Springer Science & Business Media
Total Pages: 222
Release: 2008-02-03
Genre: Science
ISBN: 1592596789
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The process whereby a single cell, the fertilized egg, develops into an adult has fascinated for centuries. Great progress in understanding that process, h- ever, has been made in the last two decades, when the techniques of molecular biology have become available to developmental biologists. By applying these techniques, the exact nature of many of the interactions responsible for forming the body pattern are now being revealed in detail. Such studies are a large, and it seems ever-expanding, part of most life-science groups. It is at newcomers to this field that this book is primarily aimed. A number of different plants and animals serve as common model org- isms for developmental studies. In Molecular Methods in Developmental Bi- ogy: Xenopus and Zebrafish, a range of the molecular methods applicable to two of these organisms are described, these are the South African clawed frog, Xenopus laevis, and the zebrafish, Brachydanio rerio. The embryos of both of these species develop rapidly and externally, making them particularly suited to investigations of early vertebrate development. However, both Xenopus and zebrafish have their own advantages and disadvantages. Xenopus have large, robust embryos that can be manipulated surgically with ease, but their pseudotetraploidy and long generation time make them unsuitable candidates for genetics. This disadvantage may soon be overcome by using the diploid Xenopus tropicalis, and early experiments are already underway. The transp- ent embryos of zebrafish render them well-suited for in situ hybridization and immunohistochemistry, and good for observing mutations in genetic screens.