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Heritable Human Genome Editing

Heritable Human Genome Editing
Author: The Royal Society
Publisher: National Academies Press
Total Pages: 239
Release: 2021-01-16
Genre: Medical
ISBN: 0309671132

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Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.


Evolution of Translational Omics

Evolution of Translational Omics
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 354
Release: 2012-09-13
Genre: Science
ISBN: 0309224187

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Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.


Disease Pathways

Disease Pathways
Author: Anastasia P. Nesterova
Publisher: Elsevier
Total Pages: 732
Release: 2019-10-18
Genre: Science
ISBN: 0128170875

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Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.


Encyclopedia of Systems Biology

Encyclopedia of Systems Biology
Author: Werner Dubitzky
Publisher: Springer
Total Pages: 2367
Release: 2013-08-17
Genre: Science
ISBN: 9781441998644

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Systems biology refers to the quantitative analysis of the dynamic interactions among several components of a biological system and aims to understand the behavior of the system as a whole. Systems biology involves the development and application of systems theory concepts for the study of complex biological systems through iteration over mathematical modeling, computational simulation and biological experimentation. Systems biology could be viewed as a tool to increase our understanding of biological systems, to develop more directed experiments, and to allow accurate predictions. The Encyclopedia of Systems Biology is conceived as a comprehensive reference work covering all aspects of systems biology, in particular the investigation of living matter involving a tight coupling of biological experimentation, mathematical modeling and computational analysis and simulation. The main goal of the Encyclopedia is to provide a complete reference of established knowledge in systems biology – a ‘one-stop shop’ for someone seeking information on key concepts of systems biology. As a result, the Encyclopedia comprises a broad range of topics relevant in the context of systems biology. The audience targeted by the Encyclopedia includes researchers, developers, teachers, students and practitioners who are interested or working in the field of systems biology. Keeping in mind the varying needs of the potential readership, we have structured and presented the content in a way that is accessible to readers from wide range of backgrounds. In contrast to encyclopedic online resources, which often rely on the general public to author their content, a key consideration in the development of the Encyclopedia of Systems Biology was to have subject matter experts define the concepts and subjects of systems biology.


Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases

Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases
Author: Nenad Blau
Publisher: Springer
Total Pages: 880
Release: 2014-07-08
Genre: Medical
ISBN: 3642403379

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This book, combining and updating two previous editions, is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for both clinicians and laboratory personnel. Reference laboratory data are scattered, and clinical descriptions may be obscure. The Physician’s Guide documents the features of more than five hundred conditions, grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). Relevant clinical findings are provided and pathological values for diagnostic metabolites highlighted. Guidance on appropriate biochemical genetic testing is provided. Established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book will be a valuable desk reference for all who deal with inherited metabolic diseases.


Molecular Biology of The Cell

Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
Total Pages: 0
Release: 2002
Genre: Cytology
ISBN: 9780815332183

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"The Human Pathway"

Author: Jim Larsson
Publisher: Jim Knut Larsson
Total Pages: 343
Release: 2010-11-15
Genre: Philosophy
ISBN: 0615413870

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Jim Knut Larsson establishes that the foundation for freewill, meaning and purpose is anchored in the latest findings in quantum mechanics and cosmology-empowering us to create the future. The Human Pathway is destined to become the catalyst for a transformation in politics, justice, government, economics and spiritualism. What choices does humanity need to make now, in order to avoid destruction? What goals can we set up to maximize meaning and purpose both for the individual and also for all of humanity? The Human Pathway might be the most important, inspiring and interesting book you will ever read. Our future depends upon your participation! Also included as an addendum: "What to do in case of arrest!" It could save your life or ... someone close to you! A must read! Some more questions ... What is "enlightenment"? Why the earth created humans? What would be the ultimate goals for humanity? How can you unleash your creative powers and create your own future? Why every act, movement and thought is a manifestation of freewill and why it affects the evolution of the universe? Why the living standard in the US declines daily? Why there are more than 3 million people in jail and more than 50 million with a criminal record? People in America always talk about "they". "Back then, 'they' castrated people who were homosexuals. "They" had strict laws against sodomy." They" did radiation experiments on the population. The question is; who are "they"? Revelation: Does it matter if you are resurrected at some point in the future? It is your desire to know the "truth" that drives your desire for resurrection. You will live forever as long as humanity-or if human intelligence lives on forever-because what is living, even if your ego is dead, is you being one with humanity. Individuals only manifest by their "clinging" to their egos. This "clinging" prevents you from becoming creative, happy and blissful. If you get rid of your ego, which should be everybody's goal, you will dedicate yourself to the eternal "now" and to serve humanity. A great quest is to help humanity reach its highest potential and to achieve "absolute" knowledge, "finish" the creation of the universe and acquire the power to recreate everything that existed forever. Then, at that point, you will be resurrected! However there is a final revelation and, if it is revealed to you, it will give you "absolute" knowledge and peace. This final revelation is the logical conclusion of this book. Understand what is written and the truth will be revealed to you. When it is, you will understand that it cannot be directly communicated and understood by others unless they have the same revelation! You will know that you have the final knowledge when you get the revelation and you don't need to seek validation for it! However, you want to share it with others! Study the revelations in this book and hopefully you will get it. You will know it when you do. We need to dismantle many laws and make society free again. We must get the government out of our lives. The benefit you get from reading my book is that you will be able to see through the myths. When you read my book, you will become an enlightened person. Actually after you read this book you will say, "I'm enlightened now". You will have revelations that will make you enjoy life more and become a happier person, but also you will no longer be seduced by propaganda. This, in the end, is a book of cosmic and spiritual enlightenment and enlightenment with regard to politics, economics and justice. What does it mean to be an enlightened person who helps secure the future prosperity and excitement of living for yourself and for humanity as a whole? Another bonus from this book is that you may no longer fear death. You will become a participant in the conversation and the future goals and aspirations of humanity.


Sequence — Evolution — Function

Sequence — Evolution — Function
Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
Total Pages: 482
Release: 2013-06-29
Genre: Science
ISBN: 1475737831

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Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.


Communities in Action

Communities in Action
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 583
Release: 2017-04-27
Genre: Medical
ISBN: 0309452961

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In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.


Clinical Neuro-Ophthalmology

Clinical Neuro-Ophthalmology
Author: Ulrich Schiefer
Publisher: Springer Science & Business Media
Total Pages: 320
Release: 2007-09-11
Genre: Medical
ISBN: 3540327088

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This book covers all relevant techniques of diagnosis as well as interpretations of clinical signs in Clinical Neuro-Ophthalmology. All information is highly structured, highlighting ‘definition’, ‘note’ and ‘pearl’, so that it can also be used by the physician during the patient encounter. The included flow chart posters remind the physician of the most important information. This unique and practical guide offers invaluable and practical advice for physicians treating patients with neuro-ophthalmic problems.