The Genetics Of Complex Thyroid Diseases PDF Download
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| Author | : T. Akamizu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 242 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 4431678859 |
Download The Genetics of Complex Thyroid Diseases Book in PDF, ePub and Kindle
The rapid developments in molecular genetics have clarified many of the muta tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin guished researchers from the United States, the United Kingdom, France, Ger many, Italy, and Japan were invited. Each presentation precipitated intense dis cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.
| Author | : Susana Nunes Silva |
| Publisher | : MDPI |
| Total Pages | : 118 |
| Release | : 2021-04-21 |
| Genre | : Medical |
| ISBN | : 303650544X |
Download Genetic Perspectives in Thyroid Cancer Book in PDF, ePub and Kindle
Thyroid cancer is an uncommon type of cancer, but it is one of the most common endocrine malignancies. The etiology of thyroid cancer is multifactorial, and radiation is the best documented risk factor related to the disease. Further risk factors have been hypothesized; however, we have yet to gather a wide range of information that will help us better understand the genetic mechanisms of thyroid cancer. The influence of genetics in the clinic and in therapeutics has been improved based on retrospective and prospective studies published worldwide in the last few decades, but the development of high through-put approaches has also been crucial. The new advances in high through-put methodologies such as next generation sequencing will open the door to new genetic variants that will help to clarify genotype–phenotype correlations, new gene associations, new genetic targets useful as potential biomarkers, and so on. The new decade that is now beginning may provide new evidence for the disease. “Genetic Perspectives in Thyroid Cancer” is an issue that intends to cover several topics on thyroid cancer, aiming to reach new findings based on genetic evidence in thyroid cancer as expressed in case studies, molecular approaches, and hereditary evidences, clinical and therapeutic developments.
| Author | : Yuri E. Nikiforov |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 451 |
| Release | : 2012-04-20 |
| Genre | : Medical |
| ISBN | : 1451114559 |
Download Diagnostic Pathology and Molecular Genetics of the Thyroid Book in PDF, ePub and Kindle
Diagnostic Pathology and Molecular Genetics of the Thyroid, Second Edition, offers a comprehensive overview of the diagnostic surgical pathology, cytopathology, immunohistochemistry and molecular genetics of the thyroid diseases, including neoplastic and non-neoplastic conditions. The book provides a detailed description of the surgical pathology of thyroid diseases side by side with major advances in immunohistochemistry and molecular genetics that can be used in evaluating thyroid tumors and non-neoplastic diseases.
| Author | : Clyde Michael Williams |
| Publisher | : |
| Total Pages | : 116 |
| Release | : 1960 |
| Genre | : Radiation |
| ISBN | : |
Download Thyroid Scanning Book in PDF, ePub and Kindle
| Author | : A. Pinchera |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 579 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 146130945X |
Download Thyroid Autoimmunity Book in PDF, ePub and Kindle
In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.
| Author | : Syed Z. Ali |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 257 |
| Release | : 2010-03-20 |
| Genre | : Medical |
| ISBN | : 0387876669 |
Download The Bethesda System for Reporting Thyroid Cytopathology Book in PDF, ePub and Kindle
This atlas is the offspring of the “The National Cancer Institute (NCI) Thyroid Fine Needle Aspiration (FNA) State of the Science Conference,” hosted by the NCI and organized by Dr. Andrea Abati. Preparations for the conference began 18 months earlier with the designation of a steering committee and the establishment of a dedicated, p- manent web site. The meeting took place on October 22 and 23, 2007 in Bethesda, Maryland and was co-moderated by Susan J. Mandel and Edmund S. Cibas. The discussions and conclusions regarding terminology and morphologic criteria 1, 2 from the meeting were summarized in publications by Baloch et al. and form the framework for this atlas. The atlas is organized by the general categories of “Nondiagnostic,” “Benign,” “Follicular Neoplasm/Suspicious for a Follicular Neoplasm”, “Suspicious for Malignancy,” and “Malignant,” and it includes the defi- tions and morphologic criteria of these categories as set forth by Baloch et al. The majority of the conference participants also agreed on a category of “undetermined significance,” which is incorporated in this atlas (Chap. 4). It is critical that the cytopathologist communicate thyroid FNA interpretations to the referring physician in terms that are succinct, unambiguous, and helpful clinically. We recognize that the terminology used here is a flexible framework that can be modified by individual laboratories to meet the needs of their providers and the patients they serve.
| Author | : Paolo Vitti |
| Publisher | : Springer |
| Total Pages | : 770 |
| Release | : 2018-09-09 |
| Genre | : Medical |
| ISBN | : 9783319450124 |
Download Thyroid Diseases Book in PDF, ePub and Kindle
This book presents the latest advances in knowledge of the pathogenesis of thyroid diseases and describes the state of the art in their diagnosis and treatment, including newly emerging management approaches. After an opening section that addresses thyroid physiology and laboratory evaluation, each of the major thyroid diseases and their subtypes is discussed, covering goiter and thyroid nodule, thyroiditis, hypothyroidism, hyperthyroidism and thyrotoxicosis, and thyroid carcinoma. Other conditions that affect thyroid function or induce thyroid dysfunction are also considered, e.g., pregnancy, non-thyroidal disorders, and medication use. The book is designed to assist practitioners to achieve optimal outcomes in clinical routine by providing clear guidance on clinical examination, the use of diagnostic tests, first- and second-line therapies, and follow-up. Chapter have been written by recognized experts in the field.
| Author | : Yehuda Shoenfeld |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 555 |
| Release | : 2010-06-08 |
| Genre | : Medical |
| ISBN | : 1603272852 |
Download Diagnostic Criteria in Autoimmune Diseases Book in PDF, ePub and Kindle
According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.
| Author | : Roy E. Weiss |
| Publisher | : Academic Press |
| Total Pages | : 462 |
| Release | : 2015-10-09 |
| Genre | : Science |
| ISBN | : 0128011343 |
Download Genetic Diagnosis of Endocrine Disorders Book in PDF, ePub and Kindle
Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases Teaches the essentials of the genetic basis of disease in each major endocrine organ system Offers expert advice from genetic counselors on how to use genetic information in counseling patients Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing
| Author | : Paul Ruggieri |
| Publisher | : Addicus Books |
| Total Pages | : 139 |
| Release | : 2012-02-01 |
| Genre | : Health & Fitness |
| ISBN | : 1936374811 |
Download A Simple Guide to Thyroid Disorders Book in PDF, ePub and Kindle
Do You Have a Thyroid Disorder? If your doctor has told you that you have a thyroid disorder, perhaps you feel some relief in having pinpointed the source of your troublesome symptoms. As you may know, thyroid ailments often elude a diagnosis since they may mimic other illnesses. Now that you have a diagnosis, becoming informed will help you receive better health care. The authors, specialists in thyroid treatment, can help you understand both the complex function of your thyroid and how your disorder can best be treated. In A Simple Guide to Thyroid Disorders, they take special care to lay out the basics in a reader-friendly way. Among the topics they discuss: &· medical tests you need to diagnose thyroid problems &· hypothyroidism...symptoms and treatment &· hyperthyroidism...symptoms and treatment &· coping with emotional highs and lows &· dealing with thyroid-related weight problems &· medications and surgeries for thyroid disorders &· thyroid nodules and cancers A Simple Guide to a Complex Disorder
