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The Future of Low Dose Radiation Research in the United States

The Future of Low Dose Radiation Research in the United States
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 143
Release: 2020-01-13
Genre: Medical
ISBN: 030949771X

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Exposures at low doses of radiation, generally taken to mean doses below 100 millisieverts, are of primary interest for setting standards for protecting individuals against the adverse effects of ionizing radiation. However, there are considerable uncertainties associated with current best estimates of risks and gaps in knowledge on critical scientific issues that relate to low dose radiation. The Nuclear and Radiation Studies Board of the National Academies hosted the symposium on The Future of Low Dose Radiation Research in the United States on May 8 and 9, 2019. The goal of the symposium was to provide an open forum for a national discussion on the need for a long-term strategy to guide a low dose radiation research program in the United States. The symposium featured presentations on low dose radiation programs around the world, panel discussions with representatives from governmental and nongovernmental organizations about the need for a low dose radiation research program, reviews of low dose radiation research in epidemiology and radiation biology including new directions, and lessons to be learned from setting up large research programs in non-radiation research fields. This publication summarizes the presentation and discussion of the symposium.


Leveraging Advances in Modern Science to Revitalize Low-Dose Radiation Research in the United States

Leveraging Advances in Modern Science to Revitalize Low-Dose Radiation Research in the United States
Author: National Academies Of Sciences Engineeri
Publisher: National Academies Press
Total Pages:
Release: 2023-03-02
Genre: Medical
ISBN: 9780309275774

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Radiation exposure at low doses (below 100 milligray) or low-dose rates (less than 5 milligray per hour) occurs in a wide range of medical, industrial, military, and commercial settings. The effects of exposure at these levels are not fully understood, but there are long-standing concerns that such exposure could negatively affect human health. Although cancer has been linked to low-dose radiation exposure for decades, there is increasing evidence that low-dose radiation exposure may also be associated with cardiovascular disease, neurological disorders, immune dysfunction, and cataracts. Recent advances in research, new tools, and a coordinated multidisciplinary research program could help fill knowledge gaps about the health impacts of low-dose radiation exposures. This report calls for the development of a U.S. research program to study how low doses of radiation affect cancer, cardiovascular disease, neurological disorders, and other disease risks. Research should also better define the impacts of radiation doses, dose rates, types of radiation, and exposure duration. The report estimates $100 million annually for the next 15 years would be required to conduct epidemiological and biological research, and to establish an infrastructure for research.


The Future of Low Dose Radiation Research

The Future of Low Dose Radiation Research
Author: United States. Congress. House. Committee on Science, Space, and Technology (2011). Subcommittee on Energy
Publisher:
Total Pages: 66
Release: 2018
Genre: Radiation
ISBN:

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Low Dose Radiation

Low Dose Radiation
Author: Antone L. Brooks
Publisher:
Total Pages:
Release: 2018
Genre: Radiation
ISBN: 9781636820248

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Introduction -- Life and times of a radiation biologist -- A brief history of radiation biology -- The birth of the DOE Low Dose Radiation Research Program -- Early observations and new technology -- Paradigm shifts in low dose radiation biology and application of data -- Biomarkers of radiation exposure and dose -- Mechanisms of action -- Modeling -- Taking a systems biology approach to risk -- Program communication and monitoring -- Current and potential impact on standards -- Applying lessons learned to future direction -- Epilogue.


Low Dose Radiation

Low Dose Radiation
Author: Antone L. Brooks
Publisher:
Total Pages: 0
Release: 2018
Genre: Science
ISBN: 9780874223545

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Chief Scientist Dr. Antone Brooks and his Low Dose Radiation Research Program team redefined the field, applying advances in instrumentation and molecular biology from the Human Genome Project and developing new technologies to examine cellular responses. Their findings were startling. At low doses, biological reactions are unique and often unrelated to those that occur at high doses. The influential linear-no-threshold model--which predicted that damage from acute exposures can be extrapolated linearly to low dose exposures--was flawed. Small doses of radiation can have an adaptive protective effect. "Hit theory," the idea that radiation only affected cells it directly traversed, yielded to "bystander theory," which hypothesizes that cells communicate with each other and a dose to one affects others surrounding it. Low Dose Radiation describes the program's development, the scientists who made it viable, and the fundamental results, highlighting lessons learned during its lifespan.


Health Risks from Exposure to Low Levels of Ionizing Radiation

Health Risks from Exposure to Low Levels of Ionizing Radiation
Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher: National Academies Press
Total Pages: 422
Release: 2006-03-23
Genre: Science
ISBN: 0309133343

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This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.


Health Effects of Exposure to Low Levels of Ionizing Radiation

Health Effects of Exposure to Low Levels of Ionizing Radiation
Author: National Research Council
Publisher: National Academies
Total Pages: 436
Release: 1990-02-01
Genre: Science
ISBN: 0309039959

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This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.


Low-Dose Radiation Effects on Animals and Ecosystems

Low-Dose Radiation Effects on Animals and Ecosystems
Author: Manabu Fukumoto
Publisher: Springer Nature
Total Pages: 259
Release: 2019-11-14
Genre: Science
ISBN: 9811382182

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This open access book summarizes the latest scientific findings regarding the biological effects of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in 2011. Various cases of changes in animals and organisms have been reported since the FNPP accident. However, it is often unknown whether they are actually due to radiation, since the dose or dose-rate are not necessarily associated with the changes observed. This book brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem. Since the biological impact of radiation is influenced by various factors, it is difficult to scientifically define the effects of low-dose/low-dose-rate radiation. However, the detailed research data presented can be combined with the latest scientific and technological advances, such as artificial intelligence, to provide new insights in the future. This book is a unique and valuable resource for researchers, professionals and anyone interested in the impact of exposure to radiation or contamination with radioactive materials.


Low-Dose Radiation

Low-Dose Radiation
Author: United States Government Accountability Office
Publisher: Createspace Independent Publishing Platform
Total Pages: 26
Release: 2018-05-11
Genre:
ISBN: 9781718981317

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LOW-DOSE RADIATION: Interagency Collaboration on Planning Research Could Improve Information on Health Effects