The Future Of Hiv 1 Therapeutics PDF Download
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Author | : Bruce E. Torbett |
Publisher | : Springer |
Total Pages | : 257 |
Release | : 2015-04-22 |
Genre | : Medical |
ISBN | : 3319185187 |
Download The Future of HIV-1 Therapeutics Book in PDF, ePub and Kindle
This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.
Author | : David G. Ostrow |
Publisher | : Springer Science & Business Media |
Total Pages | : 232 |
Release | : 1999-02-28 |
Genre | : Medical |
ISBN | : 0306459736 |
Download Psychosocial and Public Health Impacts of New HIV Therapies Book in PDF, ePub and Kindle
This volume addresses the issues surrounding combination drug therapies and the treatment of HIV/AIDS. Each chapter, written by a leading researcher, provides the latest information on the pharmacology, clinical use - including adherence to treatment guidelines - prevention implications, mental health ramifications, and ethical and policy issues. By highlighting context as well as content, and focusing on general principles in addition to specific details, this necessary text remains relevant and valuable for future treatment advances.
Author | : King K. Holmes |
Publisher | : World Bank Publications |
Total Pages | : 506 |
Release | : 2017-11-06 |
Genre | : Medical |
ISBN | : 1464805253 |
Download Disease Control Priorities, Third Edition (Volume 6) Book in PDF, ePub and Kindle
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author | : Nouri Neamati |
Publisher | : John Wiley & Sons |
Total Pages | : 710 |
Release | : 2011-08-10 |
Genre | : Science |
ISBN | : 1118015363 |
Download HIV-1 Integrase Book in PDF, ePub and Kindle
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
Author | : Saurabh Mehta |
Publisher | : CRC Press |
Total Pages | : 326 |
Release | : 2018-05-15 |
Genre | : Medical |
ISBN | : 1351058185 |
Download Nutrition and HIV Book in PDF, ePub and Kindle
The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.
Author | : World Health Organization |
Publisher | : |
Total Pages | : 429 |
Release | : 2016 |
Genre | : AIDS (Disease) |
ISBN | : 9789241549684 |
Download Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection Book in PDF, ePub and Kindle
These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.
Author | : Matthias Gotte |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2018-02-12 |
Genre | : Medical |
ISBN | : 9781493906932 |
Download Handbook of Antimicrobial Resistance Book in PDF, ePub and Kindle
While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.
Author | : Stuart LeGrice |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2015-08-06 |
Genre | : Medical |
ISBN | : 9781489999535 |
Download Human Immunodeficiency Virus Reverse Transcriptase Book in PDF, ePub and Kindle
The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable “model system” in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discuss mechanisms involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage research aimed at the development of novel RT inhibitors. The lack of bona fide RNase H inhibitors with potent antiviral activity provides an example for challenges and opportunities in the field.
Author | : World Health Organization. Department of Mental Health and Substance Abuse |
Publisher | : World Health Organization |
Total Pages | : 133 |
Release | : 2009 |
Genre | : Medical |
ISBN | : 9241547545 |
Download Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence Book in PDF, ePub and Kindle
"These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv
Author | : Guido Silvestri |
Publisher | : Springer |
Total Pages | : 248 |
Release | : 2018-10-11 |
Genre | : Medical |
ISBN | : 303002816X |
Download HIV-1 Latency Book in PDF, ePub and Kindle
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.