The Extracellular Environment In Controlling Neuronal Migration During Neocortical Development PDF Download
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Author | : Yuki Hirota |
Publisher | : Frontiers Media SA |
Total Pages | : 217 |
Release | : 2021-06-30 |
Genre | : Science |
ISBN | : 2889669300 |
Download The Extracellular Environment in Controlling Neuronal Migration During Neocortical Development Book in PDF, ePub and Kindle
Author | : Laurent Nguyen |
Publisher | : Springer Science & Business Media |
Total Pages | : 194 |
Release | : 2013-11-18 |
Genre | : Medical |
ISBN | : 940077687X |
Download Cellular and Molecular Control of Neuronal Migration Book in PDF, ePub and Kindle
Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.
Author | : Chiaki Ohtaka-Maruyama |
Publisher | : Frontiers Media SA |
Total Pages | : 185 |
Release | : 2016-07-15 |
Genre | : Neurosciences. Biological psychiatry. Neuropsychiatry |
ISBN | : 2889198863 |
Download Mechanisms of Neuronal Migration during Corticogenesis Book in PDF, ePub and Kindle
The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis.
Author | : S.H. Fatemi |
Publisher | : Springer Science & Business Media |
Total Pages | : 473 |
Release | : 2008-06-04 |
Genre | : Medical |
ISBN | : 0387767614 |
Download Reelin Glycoprotein Book in PDF, ePub and Kindle
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.
Author | : Andre M. Goffinet |
Publisher | : Springer Science & Business Media |
Total Pages | : 347 |
Release | : 2012-08-10 |
Genre | : Science |
ISBN | : 3540480021 |
Download Mouse Brain Development Book in PDF, ePub and Kindle
Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.
Author | : Catherine Lambert de Rouvroit |
Publisher | : Springer Science & Business Media |
Total Pages | : 117 |
Release | : 2013-03-12 |
Genre | : Medical |
ISBN | : 3642722571 |
Download The Reeler Mouse as a Model of Brain Development Book in PDF, ePub and Kindle
Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.
Author | : Donald W. Pfaff |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2016-10-27 |
Genre | : Medical |
ISBN | : 9781493934737 |
Download Neuroscience in the 21st Century Book in PDF, ePub and Kindle
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Author | : Abel Lajtha |
Publisher | : Springer Science & Business Media |
Total Pages | : 332 |
Release | : 2008-06-06 |
Genre | : Medical |
ISBN | : 0387326707 |
Download Handbook of Neurochemistry and Molecular Neurobiology Book in PDF, ePub and Kindle
The nervous system is highly fragile, especially during aging, illness and trauma. This book addresses a small sampling of major constituents of neural function at the cellular and molecular level that play crucial roles in development and aging.
Author | : Joe Marwah |
Publisher | : CRC Press |
Total Pages | : 304 |
Release | : 1994-02-23 |
Genre | : Medical |
ISBN | : 9780849386831 |
Download Neural Transplantation, CNS Neuronal Injury, and Regeneration Book in PDF, ePub and Kindle
This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Author | : Gerd Kempermann |
Publisher | : Oxford University Press, USA |
Total Pages | : 464 |
Release | : 2006 |
Genre | : Adulthood |
ISBN | : 9780195179712 |
Download Adult Neurogenesis Book in PDF, ePub and Kindle
The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place. This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.