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| Author | : Peng Xiao |
| Publisher | : Frontiers Media SA |
| Total Pages | : 222 |
| Release | : 2022-12-06 |
| Genre | : Medical |
| ISBN | : 2832508928 |
| Author | : Feng Wen |
| Publisher | : Frontiers Media SA |
| Total Pages | : 373 |
| Release | : 2022-09-30 |
| Genre | : Medical |
| ISBN | : 2832501257 |
| Author | : David Huang |
| Publisher | : Kugler Publications |
| Total Pages | : 594 |
| Release | : 2024-01-08 |
| Genre | : Medical |
| ISBN | : 9062999433 |
Optical coherence tomography angiography (OCTA) has undergone tremendous growth since its first commercial introduction in 2014. Because it provides injection-free, capillary-resolution, 3-dimensional angiography of the retina and choroid, OCTA is likely to overtake fluorescein as the most important angiographic imaging technique in the eye. Nearly all manufacturers of ophthalmic OCT now offer OCTA products. A PubMed search now yields over 5700 articles on OCTA and related terms. Clinical investigators have already found a use for OCTA in almost every category of retinal and optic nerve diseases. This book is meant to bring together all this information so clinicians can have one authoritative text to turn to as we begin to use this new imaging modality that was never taught when we were in formal training. Table of contents Introduction Dedication About the Editors Contributors 1. Optical coherence tomography systems for angiography 2. Optical coherence tomographic angiography algorithms 3. Vascular anatomy of the normal retina and choroid 4. OCTA of the normal anterior eye circulations 5. Artifacts 6. Quantification 7. Artificial intelligence in optical coherence tomographic angiography 8. Terminology: a new standard 9. AngioVue SSADA OCTA on the Optovue SOLIX Spectral-Domain OCT 10. Optical microangiography with AngioPlex® and PLEX® Elite systems 11. Optical coherence tomography angiography imaging on the Topcon Triton and Maestro2 systems 12. NIDEK Mirante OCT angiography 13. OCTA on the Heidelberg spectralis spectral-domain OCT 14. OCTA on the Optopol REVO NX spectral-domain OCT 15. OCTA on the Canon OCT-HS100 and Xephilio OCT-A1 Spectral-Domain OCT 16. Exudative neovascular age-related macular degeneration—Type 1, 2 and 3 neovascularization 17. Retinal angiomatous proliferation—type 3 choroidal neovascularization 18. Short- and long-term follow-up of macular neovascularization response to antiangiogenic treatment 19. Nonexudative neovascular age-related macular degeneration 20. Non-neovascular age-related macular degeneration 21. Polypoidal choroidal vasculopathy 22. Macular telangiectasia 23. Central serous chorioretinopathy 25. Nonproliferative diabetic retinopathy 26. Subclinical neovascular diabetic retinopathy 27. Proliferative diabetic retinopathy 28. Retinal venous occlusion 29. Retinal arterial occlusion 30. Plexus-specific occlusions in retinal vascular diseases 31. Paracentral acute middle maculopathy 32. Inherited retinal degenerations 33. Pathologic myopia 34. Multimodal imaging and the role of optical coherence tomography angiography in retinal vasculitis 35. White spot syndromes 36. Choroidal tumors 37. Radiation retinopathy 38. Open-angle glaucoma 39. Primary angle-closure glaucoma 40. Optic neuritis and multiple sclerosis 41. Alzheimer’s disease 42. Corneal neovascularization 43. Ocular surface and iris tumors
| Author | : Miguel A. Quiroz-Reyes, Virgilio Lima-Gomez |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 276 |
| Release | : 2023-12-21 |
| Genre | : Medical |
| ISBN | : 9815124102 |
This handbook covers Optical Coherence Tomography Angiography (OCT-A) with a specific focus on choroidal and vitreoretinal disorders. It serves as an invaluable resource for teaching and aiding daily clinical decision-making in the field. Book chapters dissect the fundamentals of angiography through OCT, offering guidance on OCT-A and insights into macular perfusional findings across various vitreoretinal and choroidal pathologies. From diabetic retinopathy to autoimmune diseases and neovascularization, the book addresses prevalent vascular entities encountered in routine practice. Furthermore, it explores innovative approaches, including antivascular endothelial growth factor molecules and extended-release delivery devices, contributing significantly to the diagnostic and decision-making processes in clinical and surgical retina care. Each chapter is contributed by experts in the relevant subspecialty. Key Features: Practical, patient-centered guide emphasizing a clinical approach. Demonstrative clinical cases for enhanced understanding. Evaluation of perfusional indices using noninvasive and noncontact imaging techniques. High histopathological correlation of structural tissue characterization with microvascular evaluation. Exploration of new perfusion concepts and their role in disease pathogenesis. Part 1 of the book focuses on OCT-A principles and applications in ophthalmology. It covers the basics of OCT-A, its contributions to eye disease study and treatment, and a comparative analysis with OCT for choroidal and vitreoretinal diseases. Additional information on nomenclature, normative datasets, and data analysis, presenting indices in different eye conditions is also presented. The emphasis is on macular perfusion in surgically resolved myopic foveoretinal detachment, postoperative evaluation in retinal detachment, and long-term analysis in diabetic retinopathy
| Author | : Josef F. Bille |
| Publisher | : Springer |
| Total Pages | : 407 |
| Release | : 2019-08-13 |
| Genre | : Medical |
| ISBN | : 3030166384 |
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
| Author | : |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 142 |
| Release | : 2019-09-04 |
| Genre | : Medical |
| ISBN | : 1838803114 |
In the last 10 years, there has been huge progress in the general understanding of ocular disorders due to the availability and development of new in vivo imaging techniques, such as anterior and posterior eye segment optical coherence tomography as well as biochemical methods allowing rapid confirmation of clinical diagnosis.Introducing noninvasive diagnostic methods in ophthalmology led to an improvement in early differential diagnosis of conditions such as corneal dystrophies, dry eye disease, and various retinal and optic nerve diseases.Recent advances in diagnostic methods have also impacted the treatment methods. This book intends to provide the reader with a comprehensive overview of current ocular diagnostic methods, including the theoretical basis as well as practical approaches and usage in clinical practice.
| Author | : Biwei Yin |
| Publisher | : |
| Total Pages | : 228 |
| Release | : 2013 |
| Genre | : |
| ISBN | : |
Optical Coherence Tomography (OCT) is a non-invasive three-dimensional imaging technique. OCT synthesizes a cross-sectional image from a series of lateral adjacent depth scans, and with a two-dimensional scanning scheme, three-dimensional intensity image of sample can be constructed. Due to its non-invasive capability, OCT has been widely applied in ophthalmology, cardiology and dermatology; and in addition to three-dimensional intensity image construction, various functional OCT imaging techniques have been developed for clinical application. My research is focused on developing functional OCT systems for application in ophthalmology, including polarization-sensitive optical coherence tomography (PS-OCT) for retinal nerve fiber layer (RNFL) birefringence measurement and dual-wavelength photothermal optical coherence tomography (DWP-OCT) for microvasculature blood oxygen saturation (SO2) measurement. In the study, a single-mode-fiber based polarization-sensitive swept-source OCT (PS-SS-OCT) with polarization modulator, polarization-sensitive bulk-optics balanced detection module is constructed and polarization processing methods based on Stokes vectors are applied to determine birefringence. PS-OCT is able to provide human subject's RNFL thickness, phase retardation, and birefringence information. Degradation in the degree of polarization (DOP) along depth is investigated and its difference between four quadrants of RNFL (superior, temporal, inferior and nasal) indicates the structural property difference. DWP-OCT is a novel functional OCT system consisting of a phase-sensitive optical coherence tomography system (PhS-OCT) and two photothermal excitation lasers. PhS-OCT is based on a swept-source laser operating in the 1060 nm wavelength range; the two photothermal excitation lasers with wavelength 770 nm and 800 nm are intensity modulated at different frequencies. PhS-OCT probe beam and two photothermal excitation beams are combined and incident on the sample, optical pathlength (op) change on the sample introduced by two photothermal excitation beams are measured and used for blood SO2 estimation. A polarization microscope is proposed for future study. The polarization microscope is an imaging technique providing molecular structure and orientation based on probe light's polarization state information. The polarization microscope uses a wavelength tunable light source, and can achieve any incident polarization state by a retarder-rotator combination. Specimen's birefringence can be determined based on the changing of detected light amplitude.
| Author | : Wolfgang Drexler |
| Publisher | : Springer |
| Total Pages | : 1346 |
| Release | : 2010-11-16 |
| Genre | : Medical |
| ISBN | : 9783540870180 |
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
| Author | : Charles J. Pavlin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 369 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461224705 |
The history of the use of ultrasound in medicine has been one of evolution of technology and innovative methods of applying this technology to imaging body structures. Many scientists and clinicians have contributed to this evolution. Ophthalmic ultrasound has become an indispensible tool in ophthalmic practice, with its own instrumentation and techniques. Ultrasound frequencies used in ophthalmology have generally been higher than those used in general medicine because of a requirement for higher resolution and a lesser need for deep penetration. Most ophthalmic diagnostic equipment uses frequencies in the 10 MHz range. The use of ultrasound frequencies in the 50-100 MHz range is a relatively new development in ultrasound imaging of the eye. This technique has been developed in our laboratories over the past several years. We have progressed from the theoretical description of the basic science required, past the first in-vitro experiments in eye bank eyes, to the construction of an instrument capable of clinical application. We have gained broad clinical experience with this instrument in normal patients and patients with ocular disease. A commercial instrument based on our original clinical scanner has recently become available, allowing other clinicians to apply this tool to ophthalmic research and clinical practice. We have applied the term ultrasound biomicroscopy to this new imaging technique because of similarities to optical biomicroscopy, i. e. , the observation of living tissue at microscopic resolution.
| Author | : Jonathan Jaoshin Liu |
| Publisher | : |
| Total Pages | : 142 |
| Release | : 2014 |
| Genre | : |
| ISBN | : |
Optical coherence tomography (OCT) is a non-contact, non-invasive, micron-scale optical imaging technology that has become a standard clinical tool in ophthalmology. Fourier domain OCT detection methods have enabled higher sensitivity and imaging speeds compared to previous generation timedomain OCT. Spectral / Fourier domain OCT (SD-OCT) detects the interference spectrum using a broadband light source and spectrometer. Swept-source / Fourier domain OCT (SS-OCT) detects the interference spectrum over time using a wavelength-swept laser. Current standard commercial ophthalmic clinical systems based on SD-OCT technology have imaging speeds of 20,000 - 40,000 axial scans per second and axial resolutions of 5 - 7 ptm. In this thesis, ultrahigh speed OCT for ophthalmic imaging applications are presented. SD-OCT systems using high speed CMOS camera technology can achieve imaging speeds over 70,000 axial scans per second. Axial resolutions better than 3 ptm can be achieved with multiplexed broadband superluminescent diodes. A novel registration motion-correction algorithm for volumetric OCT datasets reducing motion artifacts and improving signal quality is investigated. Ultrahigh speed, ultrahigh resolution SD-OCT ophthalmic imaging applications including small animal retinal imaging and clinical imaging of age-related macular degeneration (AMD) are illustrated. SS-OCT systems using short cavity wavelength-swept laser light sources can achieve imaging speeds over 100,000 axial scans per second with 6 pm axial resolution for small animal and clinical imaging. The high sensitivity of SS-OCT enables enhanced vitreous imaging, visualizing features in the vitreous and vitreoretinal interface. Finally, a new vertical cavity surface-emitting (VCSEL) technology based wavelength-swept laser light source SS-OCT system with tunable speed and wavelength range as well as long coherence length enabling ultrahigh speed and ultralong range OCT imaging applications is demonstrated. In addition to comprehensive structural imaging, the emergence of functional OCT imaging of retinal blood flow using ultrahigh speed OCT may also improve the understanding of ocular disease pathogenesis. Therefore, ultrahigh speed OCT is a promising tool for the diagnosis and management of diseases in ophthalmology.
