The Contribution Of Acute Toxicity Testing To The Evaluation Of Pharmaceuticals PDF Download
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Author | : Dietrich Schuppan |
Publisher | : Springer |
Total Pages | : 110 |
Release | : 2014-11-14 |
Genre | : Medical |
ISBN | : 3642703909 |
Download The Contribution of Acute Toxicity Testing to the Evaluation of Pharmaceuticals Book in PDF, ePub and Kindle
International Symposium. IFPMA Symposium, Geneva 30-31 October 1984
Author | : D Schuppan (Ed) |
Publisher | : |
Total Pages | : |
Release | : 1986 |
Genre | : |
ISBN | : |
Download The Contribution of Acute Toxicity Testing to the Evaluation of Pharmaceuticals Book in PDF, ePub and Kindle
Author | : Dietrich Schuppan |
Publisher | : |
Total Pages | : |
Release | : 1986 |
Genre | : |
ISBN | : 9780387153315 |
Download The Contribution of Acute Toxicity Testing to the Evaluation of Pharmaceuticals Book in PDF, ePub and Kindle
Author | : Shayne C. Gad |
Publisher | : Academic Press |
Total Pages | : 561 |
Release | : 1997-10-27 |
Genre | : Medical |
ISBN | : 008052592X |
Download Acute Toxicology Testing Book in PDF, ePub and Kindle
Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health. Key Features * Over 100 tables summarizing and interpreting results * Complete coverage of all major test designs and their limitations and advantages * Current status of alternative test designs and models
Author | : Shayne Cox Gad |
Publisher | : John Wiley & Sons |
Total Pages | : 914 |
Release | : 2016-11-07 |
Genre | : Medical |
ISBN | : 1119097398 |
Download Drug Safety Evaluation Book in PDF, ePub and Kindle
This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition
Author | : |
Publisher | : |
Total Pages | : 2 |
Release | : 1996 |
Genre | : Acute toxicity testing |
ISBN | : |
Download Guidance for industry Book in PDF, ePub and Kindle
Author | : Jean-Charles Gautier |
Publisher | : Humana Press |
Total Pages | : 431 |
Release | : 2011-08-24 |
Genre | : Medical |
ISBN | : 9781607618508 |
Download Drug Safety Evaluation Book in PDF, ePub and Kindle
Non-clinical drug safety evaluation, the assessment of the safety profile of therapeutic agents through the conduct of laboratory studies in in vitro systems and in animals, is an essential step in the progress of new pharmaceuticals heading toward the ultimate goal of clinical trials and, eventually, approval. In Drug Safety Evaluation: Methods and Protocols, expert researchers detail a compendium of analytical technologies with a focus on clarity and applicability in real life laboratory practice. These meticulous contributions feature key topics such as acute to chronic general toxicity studies, histopathology studies, reproductive toxicity studies, genotoxicity studies, safety pharmacology studies, investigative toxicity studies, and safety biomarker studies. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include brief introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Drug Safety Evaluation: Methods and Protocols serves as an ideal guide to this field, helpful to pharmaceutical scientists, toxicologists, biochemists, and molecular biologists as well as scientists from all other disciplines who wish to translate these thorough methods into their own work.
Author | : Alberto Lodola |
Publisher | : John Wiley & Sons |
Total Pages | : 280 |
Release | : 2011-03-31 |
Genre | : Medical |
ISBN | : 0470922729 |
Download Pharmaceutical Toxicology in Practice Book in PDF, ePub and Kindle
This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book proceeds to detail international regulations (including the impact of the new REACH standards for chemical safety), interdisciplinary interactions among scientists in drug development, steps in toxicity testing, and risk management. Further, the book covers the methods of genetic toxicology (assays, genomics, in vivo screening) as a complement to “traditional” toxicology in the risk assessment and risk management of pharmaceuticals.
Author | : Ali S. Faqi |
Publisher | : Academic Press |
Total Pages | : 904 |
Release | : 2012-11-02 |
Genre | : Business & Economics |
ISBN | : 0123878152 |
Download A Comprehensive Guide to Toxicology in Preclinical Drug Development Book in PDF, ePub and Kindle
A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --
Author | : |
Publisher | : |
Total Pages | : 192 |
Release | : 1986 |
Genre | : Animal experimentation |
ISBN | : |
Download Alternative Methods for Toxicity Testing Book in PDF, ePub and Kindle