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| Author | : Leslie M. Shaw |
| Publisher | : Amer. Assoc. for Clinical Chemistry |
| Total Pages | : 564 |
| Release | : 2001 |
| Genre | : Analytical chemistry |
| ISBN | : 9781890883539 |
| Author | : Hema Ketha |
| Publisher | : Academic Press |
| Total Pages | : 542 |
| Release | : 2020-06-20 |
| Genre | : Medical |
| ISBN | : 0128163739 |
Toxicology Cases for the Clinical and Forensic Laboratory brings together carefully selected case studies to teach important principles relating to drug and toxin exposures. Each case study includes contemporary clinical and forensic toxicologist studies that include a comprehensive analytical and clinical approach to patient management and address overdoses from designer drugs, to NSAIDS, to opioids, to stimulants. These cases present a comprehensive, analytical and clinical approach to managing a drug overdose. This is a must-have reference for clinical and forensic laboratory scientists, along with toxicology and pathology residents who need to know aspects of both. Brings together expert cases encompassing analytical toxicology, clinical medicine and basic science in a consolidated format Presents unique and challenging cases in clinical laboratories contributed by experts in the field Consolidated format that make concepts in toxicology easy to learn and teach Key learning points highlighted with multiple choice questions
| Author | : Barbarajean Magnani |
| Publisher | : |
| Total Pages | : 375 |
| Release | : 2020 |
| Genre | : Toxicity testing |
| ISBN | : 9781941096505 |
"A comprehensive overview of clinical laboratory toxicology services and analytes"--
| Author | : Barbarajean Magnani |
| Publisher | : |
| Total Pages | : 286 |
| Release | : 2012 |
| Genre | : Medical |
| ISBN | : 9780983706816 |
This book is a practical guide to setting up, overseeing, and directing hospital toxicology laboratory operations. It focuses on the complex issues facing the laboratory director or pathologist in this role, as well as those in training in the field of laboratory medicine. It addresses not only pharmacological principles, testing menus, and methodologies, but also clinical test interpretation for specialized areas such as the emergency department, the pain clinic, and the autopsy suite. In addition, it serves as an introduction to such topics as workplace drug testing and relevant regulatory issues. It provides the reader with a comprehensive view of what is needed--and expected--when offering a clinical toxicology service --
| Author | : John E. Whalan |
| Publisher | : Springer |
| Total Pages | : 165 |
| Release | : 2015-03-25 |
| Genre | : Medical |
| ISBN | : 3319158538 |
This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studies. In a typical toxicity study, dozens of parameters are measured several times over the course of the study. There may be hundreds of data points, each of which needs to be considered. A Toxicologist’s Guide to Clinical Pathology in Animals will serve as an essential primer for toxicologists in training and in industry as well as for researchers and professionals in a veterinary practice or a laboratory.
| Author | : John Joseph Fenton |
| Publisher | : CRC Press |
| Total Pages | : 585 |
| Release | : 2001-10-10 |
| Genre | : Law |
| ISBN | : 1420042068 |
REAL-LIFE CASES, TUTORIAL QUESTIONS, NARRATIVE HISTORY Intriguing anecdotal pedagogy, like the alleged arsenical poisonings of Napoleon and President Taylor and the probable mercury overdose of Isaac Newton, is one of the things that set Toxicology: A Case-Oriented Approach apart from other toxicology texts. Based on an undergraduate-graduat
| Author | : Hari Nair |
| Publisher | : Academic Press |
| Total Pages | : 306 |
| Release | : 2016-11-02 |
| Genre | : Science |
| ISBN | : 0128009926 |
Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab
| Author | : Frank A Barile |
| Publisher | : CRC Press |
| Total Pages | : 368 |
| Release | : 2013-04-02 |
| Genre | : Medical |
| ISBN | : 1842145282 |
Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
| Author | : Konnie Plumlee |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 504 |
| Release | : 2003-12-10 |
| Genre | : Medical |
| ISBN | : 0323058345 |
This book covers all aspects of toxicology, including toxic diseases of large animals, small animals, and exotic pets. It provides key information on how poisons affect the body, how the body responds to a foreign substance, how poisonings are diagnosed, and how poisonings are treated. Coverage includes every organ system of every species of animal with details on each body system's susceptibility to poison. Poisons affect animals differently depending on species, breed, age, gender, health status, and reproductive status. This resource addresses these differences, allowing the veterinarian to determine the class of toxicant, the mechanism of action, and the proper course of treatment. If confronted with an unknown poison, the information in this book will assist the veterinarian in formulating a list of potential poisons based on the clinical signs that the animal is exhibiting, and in choosing the appropriate tests to narrow the list to one or a few possible poisons. Most comprehensive toxicology book available Written in a user-friendly style that makes it easy to master the content Covers poisonings in both large and small domestic animals The Principles of Toxicology section provides comprehensive coverage of concepts & terminology, toxicokinetics, treatments, and regulatory information The Manifestations of Toxicoses section is devoted to differentiating between poisons based on lesions and clinical signs The Classes of Toxicants section offers detailed information on each poison, including sources, risk factors, pathophysiology, clinical signs and lesions, diagnostic testing, and treatment The author is board-certified in toxicology, and the contributors are all toxicologists and educators, ensuring authoritative, up-to-date clinical information
| Author | : Alan Woolf |
| Publisher | : Academic Press |
| Total Pages | : 648 |
| Release | : 2021-10-13 |
| Genre | : Medical |
| ISBN | : 0128222190 |
History of Modern Clinical Toxicology describes the extraordinary advances in the practice of clinical toxicology within the past 70 years and brings together stories of the people – the champions of clinical toxicology - who contributed to these advances, discovered new therapies and antidotes, and made change happen. This book lays out the poison control system they built and the fascinating story of how they created a new and evolving medical specialty. With the participation of renowned international experts as authors, the book showcases the development of poison control centers around the world and the growth of the professional societies that represent and support them today. This book also tells the stories of the modern-day toxic disasters and recent toxic exposures that gained worldwide attention and notoriety. It outlines the public health responses to such calamities which have led to improvements in our understanding of the science and changes in public health policies and regulations to forestall future such events. Finally, the book covers key policies and agencies affecting poison control centers, addresses the challenges facing clinical toxicologists of today, and predicts advances and future innovations in the field. History of Modern Clinical Toxicology is a unique resource that provides the historical and international perspective that will help students, practitioners, scientists, and health policy makers put current issues and methods in perspective. It will help them understand how infrastructure and processes in clinical toxicology have evolved and why poison control systems are configured as they are. Offers descriptions of the key regulatory advances affecting clinical toxicology Provides synopses of modern-day poisoning disasters Outlines the development of modern antidotes and future directions in clinical toxicology Describes the origins and development of the U.S. poison control system Includes the origins and features of professional clinical toxicology societies from around the world Includes descriptions of the history of clinical toxicology and poison control in more than 35 countries
