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Bloodstream

Bloodstream
Author: Tess Gerritsen
Publisher: Simon and Schuster
Total Pages: 518
Release: 2010-07-20
Genre: Fiction
ISBN: 1439140782

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With her acclaimed novels Harvest and Life Support, Tess Gerritsen has injected a powerful dose of adrenaline into the medical thriller. Now, Gerritsen melds page-turning suspense with chilling realism as a small-town doctor races to unravel the roots of a violent outbreak—before it destroys everything she loves. Lapped by the gentle waters of Locust Lake, the small resort town of Tranquility, Maine, seems like the perfect spot for Dr. Claire Elliot to shelter her adolescent son, Noah, from the distractions of the big city and the lingering memory of his father's death. But with the first snap of winter comes shocking news that puts her practice on the line: a teenage boy under her care has committed an appalling act of violence. And as Claire and all of Tranquility soon discover, it is just the start of a chain of lethal outbursts among the town's teenagers. As the rash of disturbing behavior grows, Claire uncovers a horrifying secret: this is not the first time it has happened. Twice a century, the children of Tranquility lash out with deadly violence. Claire suspects that there is a biological cause for the epidemic, and she fears that the placid Locust Lake may conceal an insidious danger. As she races to save Tranquility—and her son—from harm, Claire discovers an even greater threat: a shocking conspiracy to manipulate nature and cause innocents to slaughter.


Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition
Author: Roland N. Pittman
Publisher: Biota Publishing
Total Pages: 117
Release: 2016-08-18
Genre: Medical
ISBN: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.


Molecular Biology of The Cell

Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
Total Pages: 0
Release: 2002
Genre: Cytology
ISBN: 9780815332183

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Core Concepts in Clinical Infectious Diseases (CCCID)

Core Concepts in Clinical Infectious Diseases (CCCID)
Author: Carlos Franco-Paredes
Publisher: Academic Press
Total Pages: 246
Release: 2016-03-16
Genre: Medical
ISBN: 0128044802

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Core Concepts in Clinical Infectious Diseases (CCCID) provides medical students and researchers, infectious disease fellows, and practicing clinicians with key clinical concepts in the differential diagnosis and workup of infectious diseases. With the use of tables, charts, and problem-oriented medical diagnosis, it will provide a way of organizing and thinking about commonly seen clinical presentations of infectious diseases. Instead of discussing each disease process or any particular infectious process, this book will assist clinicians in seeing the forest and not focusing on the leaf. Graphs and tables have been constructed over 14 years of taking notes, teaching clinical infectious diseases, and discussing real clinical cases. This book is not about acquiring the structure of infectious diseases that is presented in classic textbooks of infectious disease; instead, it is about refining the process of putting the pieces together in clinical thinking to achieve an accurate clinical diagnosis and thus improved patient care. Assists the reader in connecting the dots (process of accumulating real-time knowledge) during the thinking process of clinical decision-making in the area of infectious diseases Uses tables and charts for easy understanding and application Contains a manual style that targets different audiences, such as medical students, hospital medicine specialists, outpatient internal medicine practitioners, infectious disease fellows in training, and practicing clinicians Provides an up-to-date discussion of core concepts in clinical infectious diseases


Caffeine for the Sustainment of Mental Task Performance

Caffeine for the Sustainment of Mental Task Performance
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 172
Release: 2002-01-07
Genre: Medical
ISBN: 0309082587

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This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.


Vascular Responses to Pathogens

Vascular Responses to Pathogens
Author: Felicity N.E. Gavins
Publisher: Academic Press
Total Pages: 254
Release: 2015-10-31
Genre: Medical
ISBN: 0128013257

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Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease. Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs


Vessel Health and Preservation: The Right Approach for Vascular Access

Vessel Health and Preservation: The Right Approach for Vascular Access
Author: Nancy L. Moureau
Publisher: Springer
Total Pages: 303
Release: 2019-06-10
Genre: Medical
ISBN: 3030031497

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This Open access book offers updated and revised information on vessel health and preservation (VHP), a model concept first published in poster form in 2008 and in JVA in 2012, which has received a great deal of attention, especially in the US, UK and Australia. The book presents a model and a new way of thinking applied to vascular access and administration of intravenous treatment, and shows how establishing and maintaining a route of access to the bloodstream is essential for patients in acute care today. Until now, little thought has been given to an intentional process to guide selection, insertion and management of vascular access devices (VADs) and by default actions are based on crisis management when a quickly selected VAD fails. The book details how VHP establishes a framework or pathway model for each step of the patient experience, intentionally guiding, improving and eliminating risk when possible. The evidence points to the fact that reducing fragmentation, establishing a pathway, and teaching the process to all stakeholders reduces complications with intravenous therapy, improves efficiency and diminishes cost. As such this book appeals to bedside nurses, physicians and other health professionals.


Life Support

Life Support
Author: Tess Gerritsen
Publisher: Random House
Total Pages: 484
Release: 2010
Genre: Medical innovations
ISBN: 055382452X

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Dr Toby Harper's quiet night is disrupted when a severely ill man stumbles into ER. She suspects a viral brain infection. But shortly after trying to treat him, he disappears without a trace. When a second person is admitted with the same symptoms, she starts to trace the deadly infection backwards. And begins to suspect foul play.


The Blood Brain Barrier (BBB)

The Blood Brain Barrier (BBB)
Author: Gert Fricker
Publisher: Springer
Total Pages: 169
Release: 2014-10-24
Genre: Science
ISBN: 3662437872

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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.