Test No 478 Rodent Dominant Lethal Test PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Test No 478 Rodent Dominant Lethal Test PDF full book. Access full book title Test No 478 Rodent Dominant Lethal Test.
| Author | : Organisation de coopération et de développement économiques |
| Publisher | : |
| Total Pages | : 15 |
| Release | : 2015 |
| Genre | : |
| ISBN | : |
Download Test No. 478: Rodent Dominant Lethal Test Book in PDF, ePub and Kindle
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells. In addition, the dominant lethal test is relevant to assessing genotoxicity because, although they may vary among species, factors of in vivo metabolism, pharmacokinetics and DNA-repair processes are active and contribute to the response. Induction of a DL mutation after exposure to a test chemical indicates that the chemical has affected germinal tissue of the test animal. This modified version of the Test Guideline reflects more than thirty years of experience with this test and the potential for integrating or combining this test with other toxicity tests such as developmental, reproductive toxicity, or genotoxicity studies; however due to its limitations and the use of a large number of animals this assay is not intended for use as a primary method, but rather as a supplemental test method which can only be used when there is no alternative for regulatory requirements.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 15 |
| Release | : 2015-07-28 |
| Genre | : |
| ISBN | : 9264243119 |
Download Test No. 478: Rodent Dominant Lethal Test Book in PDF, ePub and Kindle
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 6 |
| Release | : 1984-04-04 |
| Genre | : |
| ISBN | : 9264071369 |
Download Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test Book in PDF, ePub and Kindle
Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, ...) indicates that the substance has affected germinal tissue of the test species ...
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 15 |
| Release | : 2016-07-29 |
| Genre | : |
| ISBN | : 9264264825 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 478: Rodent Dominant Lethal Test Book in PDF, ePub and Kindle
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells.
| Author | : |
| Publisher | : |
| Total Pages | : 6 |
| Release | : 1998 |
| Genre | : Embryos |
| ISBN | : |
Download OPPTS 870.5450 Rodent Dominant Lethal Assay Book in PDF, ePub and Kindle
| Author | : Neal R. Cutler |
| Publisher | : John Wiley & Sons |
| Total Pages | : 272 |
| Release | : 2010-01-22 |
| Genre | : Medical |
| ISBN | : 9781444318586 |
Download Critical Pathways to Success in CNS Drug Development Book in PDF, ePub and Kindle
Covering the latest advances in CNS drug development, this bookwill guide all those involved in pre-clinical to early clinicaltrials. The authors describe how recent innovations can acceleratethe development of novel CNS compounds, improve early detection ofefficacy and toxicity signals, and increase the safety oflater-stage clinical trials. The current crisis in the drug development industry iscritically reviewed, as well as the steps needed to correct theproblems, including new government-backed regulations andindustry-based innovations designed to accelerate CNS drugdevelopment in the future. Animal-based models of major CNS disorders are described indetail, and the ability of the latest in vitro and computer-basedmodels to simulate CNS disease states and predict drug efficacy andside-effects are examined. Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations
| Author | : Laura Robinson |
| Publisher | : John Wiley & Sons |
| Total Pages | : 400 |
| Release | : 2018-11-05 |
| Genre | : Science |
| ISBN | : 1118882075 |
Download A Practical Guide to Toxicology and Human Health Risk Assessment Book in PDF, ePub and Kindle
Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author’s training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.
| Author | : Peter Fisk |
| Publisher | : John Wiley & Sons |
| Total Pages | : 334 |
| Release | : 2013-10-28 |
| Genre | : Science |
| ISBN | : 1118684079 |
Download Chemical Risk Assessment Book in PDF, ePub and Kindle
This book is an essential guide and support to understanding of the science and policy, procedure and practice that underpins the REACH risk assessments required for the use and placing on the market of chemicals in the European Union. A clear understanding of information provision and how this affects the assessment of chemical safety is fundamentally important to the success of policy on chemicals and ultimately to the sustainability of the chemicals industry. Within the book, the scientific processes that underpin the policy are explained in a practical way. Importantly, it includes coverage of techniques to help solve the problems of using potentially risky and hazardous chemicals through the use of less hazardous alternatives and ‘green chemistry’, and also the analysis of the risks of the use of the most hazardous substances against the social and economic benefits of use. Chemical Risk Assessment: A Manual for REACH covers the following main themes: i) Assessment of chemical risk; ii) Risk management; iii) Hazard reduction, substitution and green chemistry; iv) Risk versus benefit – socio-economic analysis. The book acts as a practical guide and overview to chemicals risk assessment and risk management (in the EU context), as well as a support text for planning for the challenges of the future, which will see ever-increasing pressure to withdraw hazardous substances from the EU (and global) market, balanced against opportunities for innovation in the development of less hazardous chemicals.
| Author | : Michael J. Derelanko |
| Publisher | : CRC Press |
| Total Pages | : 1448 |
| Release | : 2001-08-29 |
| Genre | : Medical |
| ISBN | : 9780849303708 |
Download Handbook of Toxicology, Second Edition Book in PDF, ePub and Kindle
LOCATE FREQUENTLY USED INFORMATION EASILY AND QUICKLY Working in the laboratory or office, you use a diverse assortment of basic information to design, conduct, and interpret toxicology studies and to perform risk assessments. The Second Edition of the best-selling Handbook of Toxicology gives you the information you need in a single reference source. NEW IN THIS EDITION: Expanded coverage of inhalation toxicology, neurotoxicology, and histopathology Additional regulatory chapters dealing with pesticides, medical devices, consumer products, and world-wide notification of new chemicals Areas of toxicology missing from the first edition such as ecotoxicology and in vitro toxicology A chapter providing extensive overview of the toxicology of metals Two chapters on basic male and female endocrinology and related toxicology Information on differences in physiological and biochemical parameters between children and adults References to Web site sources of valuable information Over 200 new tables and figures THE SINGLE SOURCE FOR THE INFORMATION YOU USE MOST FREQUENTLY Updated and expanded, this unique book includes practical reference information useful to toxicologists in the chemical and pharmaceutical industries, contract laboratories, regulatory agencies, and academia. To help you find information quickly and easily, data is arranged by toxicology subspecialty and each chapter begins with a detailed listing of information presented. Containing over 700 tables and figures, Handbook of Toxicology, Second Edition gives you a single source for the information you use most often.
| Author | : Bengt Fadeel |
| Publisher | : Academic Press |
| Total Pages | : 488 |
| Release | : 2017-02-14 |
| Genre | : Medical |
| ISBN | : 0128094907 |
Download Adverse Effects of Engineered Nanomaterials Book in PDF, ePub and Kindle
Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population. Uses a schematic, non-exhaustive approach to summarizes the most important research data in this field Discusses the health implications of experimental data in nanotoxicology Presents a completely revised edition that focuses on the human health impacts of engineered nanomaterials, including many organ-specific chapters
