Test No 431 In Vitro Skin Corrosion Reconstructed Human Epidermis Rhe Test Method PDF Download
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 34 |
Release | : 2013-07-26 |
Genre | : |
ISBN | : 9264203826 |
Download Test No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method Book in PDF, ePub and Kindle
The present Test Guideline addresses the human health hazard endpoint skin corrosion, following exposure to a test chemical. Skin corrosion is defined as the production of irreversible tissue damage, manifested as visible necrosis of the skin ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 29 |
Release | : 2019-06-18 |
Genre | : |
ISBN | : 9264264612 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Book in PDF, ePub and Kindle
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2013 |
Genre | : |
ISBN | : |
Download Test No. 431 Book in PDF, ePub and Kindle
Author | : Organisation de coopération et de développement économiques |
Publisher | : |
Total Pages | : 26 |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Test No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method Book in PDF, ePub and Kindle
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information. The test protocol may also provide an indication of the distinction between severe and less severe skin corrosives. This Test Guideline does not require the use of live animals or animal tissue for the assessment of skin corrosivity. The test material (solid or liquid) is applied uniformly and topically to a three-dimensional human skin model, comprising at least a reconstructed epidermis with a functional stratum corneum. Two tissue replicates are used for each treatment (exposure time), and for controls. Corrosive materials are identified by their ability to produce a decrease in cell viability below defined threshold levels at specified exposure periods. Coloured chemicals can also be tested by used of an HPLC procedure. The principle of the human skin model assay is based on the hypothesis that corrosive chemicals are able to penetrate the stratum corneum by diffusion or erosion, and are cytotoxic to the underlying cell layers.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 8 |
Release | : 2004-11-23 |
Genre | : |
ISBN | : 9264071148 |
Download Test No. 431: In Vitro Skin Corrosion: Human Skin Model Test Book in PDF, ePub and Kindle
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using ...
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2013 |
Genre | : |
ISBN | : |
Download Test No. 439 Book in PDF, ePub and Kindle
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 26 |
Release | : 2015-07-28 |
Genre | : |
ISBN | : 9264242759 |
Download Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method Book in PDF, ePub and Kindle
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
Author | : Organisation for Economic Co-operation and Development |
Publisher | : Organisation for Economic Co-operation and Development ; [Montréal : Renouf] |
Total Pages | : |
Release | : 1981 |
Genre | : Chemical industry |
ISBN | : 9789264122215 |
Download OECD Guidelines for Testing of Chemicals Book in PDF, ePub and Kindle
Author | : Hajime Kojima |
Publisher | : Springer |
Total Pages | : 130 |
Release | : 2018-12-27 |
Genre | : Medical |
ISBN | : 9811324476 |
Download Alternatives to Animal Testing Book in PDF, ePub and Kindle
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
Author | : Chantra Eskes |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2018-08-30 |
Genre | : Medical |
ISBN | : 9783319843780 |
Download Alternatives for Dermal Toxicity Testing Book in PDF, ePub and Kindle
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.