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Data requirements and protocol for determining comparative efficacy of vector control products

Data requirements and protocol for determining comparative efficacy of vector control products
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 36
Release: 2024-05-16
Genre: Medical
ISBN: 9240092749

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The aim of this protocol is to support the conduct of entomological comparative efficacy assessments for vector control products and the associated non-inferiority analysis. This evidence is used to inform discussions within the guidelines development context as to whether a new vector control product should be considered as covered by one or more existing WHO recommendations or not. Alternatively, the evidence may inform the extension of an existing WHO recommendation or the development of a new one, provided that non-inferiority is demonstrated.


WHO Malaria Policy Advisory Group (MPAG) meeting report, 18–20 April 2023

WHO Malaria Policy Advisory Group (MPAG) meeting report, 18–20 April 2023
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 29
Release: 2023-06-01
Genre: Medical
ISBN: 9240074384

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On 18–20 April 2023, the WHO Malaria Policy Advisory Group (MPAG) convened to review updates and progress, and to provide guidance on thematic areas of work by the Global Malaria Programme. The meeting focused on the following topics: 1) the RBM Partnership to End Malaria evaluation of the “High burden to high impact” (HBHI) approach; 2) updates on the vector control, treatment and diagnostic recommendations in the WHO guidelines for malaria; 3) revisiting comparative effectiveness in the context of the arrival of new vector control products; 4) an update on certification of malaria elimination and the E-2025 Global Forum; 5) an update on the RTS,S/AS01 Malaria Vaccine Implementation Programme and WHO evidence review for the R21/Matrix-M vaccine; 6) an update on the work areas of the Strategic Information for Response Unit; 7) a report from the technical consultation on the effectiveness of rectal artesunate (RAS) and field implementation manual; 8) a report from the technical consultation on community-based delivery of intermittent preventive treatment of malaria in pregnancy (IPTp); 9) an update on the WHO/TDR field implementation manual for seasonal malaria chemoprevention (SMC); 10) an update on the Anopheles stephensi regional strategy; 11) an update on histidine-rich protein 2 (HRP2) gene deletions and global response plan; and 12) an update on antimalarial drug resistance in Africa.


Technical consultation on determining non-inferiority of vector control products within an established class

Technical consultation on determining non-inferiority of vector control products within an established class
Author:
Publisher: World Health Organization
Total Pages: 30
Release: 2021-11-24
Genre: Medical
ISBN: 9240038019

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This meeting report describes the discussion and outcomes of the technical consultation on the value of non-inferiority assessments within the vector control evaluation process, for interventions that fall within an established intervention class. The discussion was based on pilot trials assessing non-inferiority of pyrethroid-PBO nets against malaria. Objectives of the meeting included determining the value, and challenges associated with using non-inferiority assessments and considerations of how these evaluations could be implemented within the existing framework of the WHO vector control evaluation process.


WHO Malaria Policy Advisory Group (MPAG) meeting report, 30 October–1 November 2023

WHO Malaria Policy Advisory Group (MPAG) meeting report, 30 October–1 November 2023
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 22
Release: 2024-02-21
Genre: Medical
ISBN: 9240089640

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On 30 October–1 November 2023, the WHO Malaria Policy Advisory Group (MPAG) convened to review updates and progress, and to provide guidance on thematic areas of work by the Global Malaria Programme. The meeting focused on the following topics: the Global Malaria Programme operational strategy 2024–2030; malaria vaccines R21/Matrix-M and RTS,S/AS01, the Malaria Vaccine Implementation Programme (MVIP) and status of malaria vaccine roll-out; guiding principles for prioritizing malaria interventions in resource-constrained settings to achieve maximum impact; progress and challenges on subnational tailoring of interventions; comparative effectiveness in the context of the arrival of new vector control products; the “High burden to high impact” (HBHI) approach; the WHO guidelines for malaria; antimalarial drug resistance in Africa; and the Mekong Malaria Elimination programme.


Toolkit for Integrated Vector Management in Sub-Saharan Africa (A)

Toolkit for Integrated Vector Management in Sub-Saharan Africa (A)
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 242
Release: 2016-07-27
Genre: Medical
ISBN: 9241549653

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This toolkit for integrated vector management (IVM) is designed to help national and regional programme managers coordinate across sectors to design and run large IVM programmes. It is an extension of earlier guidance and teaching material published by the World Health Organization (WHO): Handbook for integrated vector management Monitoring and evaluation indicators for integrated vector management Guidance on policy-making for integrated vector management and Core structure for training curricula on integrated vector management. The toolkit provides the technical detail required to plan implement monitor and evaluate an IVM approach. IVM can be used when the aim is to control or eliminate vector-borne diseases and can also contribute to insecticide resistance management. This toolkit provides information on where vector-borne diseases are endemic and what interventions should be used presenting case studies on IVM as well as relevant guidance documents for reference. The diseases that are the focus of this toolkit are malaria lymphatic filariasis dengue leishmaniasis onchocerciasis human African trypanosomiasis and schistosomiasis. It also includes information on other viral diseases (Rift Valley fever West Nile fever Chikungunya yellow fever) and trachoma. If other vector-borne diseases appear in a country or area vector control with an IVM approach should be adopted as per national priorities. Malaria as one of the most important vector-borne diseases in sub-Saharan Africa is the main focus of this document. Programmes targeting other vector-borne diseases can learn from the experiences gained from malaria vector control and presented here.


Saving Lives, Buying Time

Saving Lives, Buying Time
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 384
Release: 2004-09-09
Genre: Medical
ISBN: 0309165938

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For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.


World malaria report 2022

World malaria report 2022
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 372
Release: 2022-12-08
Genre: Medical
ISBN: 9240064893

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Each year, WHO’s World malaria report offers in-depth information on the latest trends in malaria control and elimination at global, regional and country levels. The report highlights progress towards global targets and describes opportunities and challenges for curbing and eliminating the disease. This year’s report includes three new sections on: (1) global and regional initiatives launched in 2021 and 2022; (2) global malaria surveillance and country-level case studies on surveillance systems assessments; and (3) research and development. The report also includes an expanded section on threats to malaria control, with a focus on the declining effectiveness of insecticide-treated mosquito nets.


Disease Prevention Through Vector Control

Disease Prevention Through Vector Control
Author: Madeleine C. Thomson
Publisher: Oxfam
Total Pages: 132
Release: 1995
Genre: Medical
ISBN: 9780855983062

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This work is intended to help development workers and planners to identify and assess the risks of vector-borne diseases in a camp and to plan and implement cost-effective ways of controlling them. The main vector-borne diseases are described, the importance of identifying the particular disease, and of considering methods of control is emphasized.