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| Author | : Salem Chouaib |
| Publisher | : Frontiers Media SA |
| Total Pages | : 196 |
| Release | : 2020-07-02 |
| Genre | : |
| ISBN | : 2889638170 |
| Author | : Pawel Kalinski |
| Publisher | : Springer |
| Total Pages | : 271 |
| Release | : 2017-12-22 |
| Genre | : Medical |
| ISBN | : 331967577X |
The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
| Author | : Peter P. Lee |
| Publisher | : Springer Nature |
| Total Pages | : 326 |
| Release | : 2020-03-25 |
| Genre | : Medical |
| ISBN | : 303038862X |
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
| Author | : Rebecca G. Bagley |
| Publisher | : Springer |
| Total Pages | : 770 |
| Release | : 2010-09-09 |
| Genre | : Medical |
| ISBN | : 9781441966148 |
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.
| Author | : Rebecca G. Bagley |
| Publisher | : Springer |
| Total Pages | : 770 |
| Release | : 2012-11-06 |
| Genre | : Medical |
| ISBN | : 9781461426608 |
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.
| Author | : Mansoor M. Amiji |
| Publisher | : Academic Press |
| Total Pages | : 550 |
| Release | : 2021-08-18 |
| Genre | : Business & Economics |
| ISBN | : 012823637X |
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
| Author | : Joschka Matthias Bartneck |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2023 |
| Genre | : |
| ISBN | : |
The treatment of cancer diseases is one of the greatest challenges for modern medicine. In addition to conventional cancer therapy approaches, cancer immunotherapy has been gaining importance for more than two decades. In this context, the use of cancer vaccines that induce the formation of high-quality tumor-specific T cells is a promising tool that is now being intensively researched. Therapeutic approaches are needed that specifically sensitize the host immune system to the tumor and are able to specifically address targets in the complex immune-inhibitory network of the tumor microenvironment, a major obstacle affecting the efficiency of immunotherapeutic approaches. The transcutaneous immunization method developed in the research group of Prof. Dr. Markus Radsak enables the generation of antigen-specific CD8+ and CD4+ T cells by activating skin tissue-resident antigen-presenting cells. With the aim of first optimizing the memory T cell response, the frequency of antigen-specific activated T cells was massively increased in the present work by multiple TCI. The optimized Dithranol-Imiquimod-based transcutaneous immunization (DIVA2) enabled protection against MC38mOVA tumor cells in a prophylactic tumor setting. Applied in a therapeutic Tumor setting, DIVA2 resulted in transient tumor immune control. High-dimensional flow cytometry analysis and single-cell mRNA-sequencing of tumor-infiltrating leukocytes showed that DIVA2-induced cytotoxic CD8+ T cells facilitate initial tumor immune control, but are inhibited by immunosuppressive CCR2+ PD L1+ monocyte-derived myeloid-derived suppressor cells (M-MDSC), resulting in partial T-cell exhaustion. Furthermore, CD38 expression by macrophages during immune control implicated production of the immunosuppressive adenosine. Anti-CCR2 antibody-based depletion of CCR2+ monocytes in the tumor experiment highlighted their immunosuppressive nature, but could not persistently limit tumor growth as depletion could not be continuously ensured. The use of the immune checkpoint inhibitor anti-PD-1 enabled a strong regression of the tumors in a therapeutic tumor setting, which illustrates the immunosuppressive role of the PD-1/PD-L1 axis in the tumor microenvironment of MC38mOVA tumors after initial DIVA2-induced immune control. In summary, the present work provides a platform for generating a strong antigen-specific primary and memory T cell immune response using the optimized transcutaneous immunization method DIVA2. This enables protection against tumor cells and transient therapeutic immune control of solid tumors. For a successful therapeutic elimination of tumors, the identification of specific immune targets is necessary.
| Author | : Matthias Theobald |
| Publisher | : Springer Nature |
| Total Pages | : 190 |
| Release | : 2019-08-31 |
| Genre | : Medical |
| ISBN | : 3030237656 |
This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.
| Author | : Alexander Birbrair |
| Publisher | : Springer Nature |
| Total Pages | : 122 |
| Release | : 2020-02-14 |
| Genre | : Science |
| ISBN | : 3030383156 |
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-1, IL-8, IL-21, IL-36 signaling, and more. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part A updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
| Author | : Vita Golubovskaya |
| Publisher | : Mdpi AG |
| Total Pages | : 0 |
| Release | : 2022-07-05 |
| Genre | : Medical |
| ISBN | : 9783036544199 |
The book is based on the Cancers journal Special Issue entitled "Immunotherapy, Tumor Microenvironment and Survival Signaling", and focuses on important problems concerning tumors and tumor microenvironment interactions, as well as novel immunotherapies such as CAR-T cell therapy. Immunotherapies have recently shown remarkable results in the treatment of cancer patients. However, there are still many questions that remain to be solved in regards to more effective therapies, such as the tumor heterogeneous profile, tumor microenvironment, and tumor survival epigenetic and genetic pathways, all of which make patients resistant to the presently available treatments for cancer. This book demonstrates different approaches to overcome the challenges faced by immunotherapies due to suppressive tumor microenvironments. This book includes 18 papers that can be divided into three chapters: 1. novel immunotherapies; 2. targeting tumor microenvironment and novel approaches; 3. targeting tumors and tumor microenvironment in different types of cancer.
