Targeted Molecular Imaging of Brain Cancer
Author | : Reinier Hernandez |
Publisher | : |
Total Pages | : 0 |
Release | : 2016 |
Genre | : |
ISBN | : |
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Author | : Reinier Hernandez |
Publisher | : |
Total Pages | : 0 |
Release | : 2016 |
Genre | : |
ISBN | : |
Author | : E. Edmund Kim |
Publisher | : Springer Science & Business Media |
Total Pages | : 302 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 1475735057 |
This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.
Author | : |
Publisher | : |
Total Pages | : 121 |
Release | : 2016 |
Genre | : |
ISBN | : |
Author | : Michael J. Welch |
Publisher | : Taylor & Francis |
Total Pages | : 378 |
Release | : 2012-02-24 |
Genre | : Medical |
ISBN | : 1439841969 |
Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies t
Author | : Otmar Schober |
Publisher | : Springer Nature |
Total Pages | : 911 |
Release | : 2020-06-27 |
Genre | : Medical |
ISBN | : 3030426181 |
This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit all readers who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.
Author | : Jay J. Pillai |
Publisher | : Springer Science & Business Media |
Total Pages | : 253 |
Release | : 2013-10-16 |
Genre | : Medical |
ISBN | : 1441958584 |
This book presents a comprehensive overview of current state-of-the-art clinical physiological imaging of brain tumors. It focuses on the clinical applications of various modalities as they relate to brain tumor imaging, including techniques such as blood oxygen level dependent functional magnetic resonance imaging, diffusion tensor imaging, magnetic source imaging/magnetoencephalography, magnetic resonance perfusion imaging, magnetic resonance spectroscopic imaging, amide proton transfer imaging, high angular resolution diffusion imaging, and molecular imaging. Featuring contributions from renowned experts in functional imaging, this book examines the diagnosis and characterization of brain tumors, details the application of functional imaging to treatment planning and monitoring of therapeutic intervention, and explores future directions in physiologic brain tumor imaging. Intended for neuro-oncologists, neurosurgeons, neuroradiologists, residents, and medical students, Functional Imaging of Brain Tumors is a unique resource that serves to advance patient care and research in this rapidly developing field.
Author | : Rajan Jain |
Publisher | : Thieme |
Total Pages | : 785 |
Release | : 2015-08-19 |
Genre | : Medical |
ISBN | : 1604068302 |
A concise yet in-depth analysis of imaging modalities for brain tumors FOUR STARS from Doody's Star Ratings™ Brain Tumor Imaging is a practical, comprehensive reference that covers all the methods of imaging used in the diagnosis and assessment of brain tumors. It includes key information on the use of advanced imaging technologies in the clinical setting for the successful treatment of patients with brain tumors. Key Features: Includes more than 500 high-quality images (color as well as black and white) that help illustrate the latest imaging modalities used in neuro-oncology Covers advanced, functional imaging techniques, giving readers the latest information on clinically advanced imaging tools for brain tumor assessment Provides details on how to accurately evaluate treatment effects and differentiate from tumor progression This book is an essential guide to advanced imaging modalities for all radiologists, neuro-radiologists, neuro-oncologists, and neurosurgeons involved in the treatment and evaluation of patients with brain tumors.
Author | : Elke Hattingen |
Publisher | : Springer |
Total Pages | : 166 |
Release | : 2015-09-02 |
Genre | : Medical |
ISBN | : 3642450407 |
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Author | : Rajan Jain |
Publisher | : Thieme |
Total Pages | : 784 |
Release | : 2015-08-19 |
Genre | : Medical |
ISBN | : 1638532435 |
A concise yet in-depth analysis of imaging modalities for brain tumors FOUR STARS from Doody's Star Ratings™ Brain Tumor Imaging is a practical, comprehensive reference that covers all the methods of imaging used in the diagnosis and assessment of brain tumors. It includes key information on the use of advanced imaging technologies in the clinical setting for the successful treatment of patients with brain tumors. Key Features: Includes more than 500 high-quality images (color as well as black and white) that help illustrate the latest imaging modalities used in neuro-oncology Covers advanced, functional imaging techniques, giving readers the latest information on clinically advanced imaging tools for brain tumor assessment Provides details on how to accurately evaluate treatment effects and differentiate from tumor progression This book is an essential guide to advanced imaging modalities for all radiologists, neuro-radiologists, neuro-oncologists, and neurosurgeons involved in the treatment and evaluation of patients with brain tumors.
Author | : Zhao Li |
Publisher | : |
Total Pages | : 184 |
Release | : 2015 |
Genre | : |
ISBN | : |
The common theme of my 5-year PhD research is to channel progress in spin physics and nano-bio-materials into meaningful improvements in the theoretical studies, methodological developments, and advanced applications of magnetic resonance (MR) to: 1) MR Molecular Imaging: to detect lesions (especially cancers) at early stages through imaging the existence and locations of physiologically important biomarkers; and 2) MR Nano Medicine: to cure diseases (especially cancers) by targeted therapy through nanodrugs and hyperthermia. The research activities had encompassed a balanced approach to develop a rigorous theoretical understanding on sensitively imaging magnetic nanoparticles by active- feedback spin dynamics of selective self-excitation and fixed-point dynamics on one hand and sound methodology with biomedical applicability to early pancreatic cancers and brain tumors detection on the other. Computer simulations, phantom experiments of superparamagnetic nanoparticles, and in vivo experiments of orthotopic pancreatic cancer and brain tumor mouse models had been used to validate the applicability and efficacy of our proposed methods. The major research projects and achievements with my coworkers under the supervision of Prof. Yung-Ya Lin include: 1) Developed original MR method, "Active-Feedback Fixed-Point Imaging", for early cancer detection, with both quantum and classical formulation of the spin dynamics. 2) Demonstrated 3-5 times of enhancement in the contrast-to-noise ratio (CNR) of early pancreatic cancers which were targeted and labeled by CA19-9 conjugated magnetic nanoparticles by our "Spin Avalanche Amplification" method, based on statistics from 7 orthotopic pancreatic cancer mouse models. 3) Demonstrated 4-10 times of enhancement in the CNR of early GBM (glioblastoma multiforme, the most common and aggressive form of brain cancers) by our "Active-Feedback Fixed-Point Imaging" method, based on statistics from 20 orthotopic GBM mouse models. 4) Developed novel multifunctional, theranostic, smart nanoparticles, called "UCS-Gd-Dox" for MR imaging and targeted cancer therapy. By conjugating Gd3+ at the stable core of unibody core-shell polymer (UCS) and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1 = 0.9 and 14.5 mM-1s-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect is significantly better than free cancer drugs in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. 5) Formulated more accurate theoretical description to magnetic resonance hyperthermia, including aggregation/disruption of monomers/clusters and nonlinear response under strong external magnetic field.