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Systems Thinking in Medicine and New Drug Discovery

Systems Thinking in Medicine and New Drug Discovery
Author: Robert E. Smith
Publisher: Cambridge Scholars Publishing
Total Pages: 632
Release: 2018-12-17
Genre: Medical
ISBN: 1527523667
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Total Quality Management (TQM) and systems thinking are being used to improve all aspects of human health. This first book in a two-volume set details how the healthcare community is working with patients and their caregivers to improve healthcare and reduce its costs. Systems-based thinking encourages us to work together to look at the effects of new drugs on entire systems and not just single molecular targets. It also leads us to a better understanding of genetics and epigenetics, as well as the deep ecology of the human body. The healthcare community is developing targeted therapies that stimulate our own bodies to cure ourselves and eliminate the need for animal testing. This book will appeal to specialists, who will find recommendations on safer materials for 3D bioprinting and ways to analyze dietary supplements for toxic contaminants, and physicians, pharmacists and non-professionals, who will learn the important different ways that dietary supplements and prescription drugs are developed, sold and marketed.

Systems Thinking in Medicine and New Drug Discovery

Systems Thinking in Medicine and New Drug Discovery
Author: Robert E. Smith
Publisher: Cambridge Scholars Publishing
Total Pages: 347
Release: 2018-12-19
Genre: Medical
ISBN: 1527523772
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This second book in a two-volume set tells how the healthcare community is working with patients and their caregivers to help improve health using P4 medicine, proper nutrition and a healthy lifestyle. The healthcare community is finding ways to predict one’s susceptibility to diseases, so they can be prevented from occurring, when possible. When diseases do emerge, it is developing personalized therapies and ways for patients to participate in their own healthcare. At the same time, systems thinking dispels many misconceptions, such as ‘natural’ foods and ‘superfoods’. In fact, the only true superfood is mother’s breast milk. Also, dietary antioxidants prevent inflammation by activating our natural antioxidant system (Nrf2). However, environmental toxins can counteract our best efforts. Still, systems thinking encourages us to fix the problem and not the blame. This book will appeal to professionals, non-professionals and patients, who can learn how to improve healthcare and prevent diseases, while reversing the effects of global climate change.

Advances in Patient Safety

Advances in Patient Safety
Author: Kerm Henriksen
Publisher:
Total Pages: 526
Release: 2005
Genre: Medical
ISBN:
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v. 1. Research findings -- v. 2. Concepts and methodology -- v. 3. Implementation issues -- v. 4. Programs, tools and products.

Systems Thinking for Health Systems Strengthening

Systems Thinking for Health Systems Strengthening
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 113
Release: 2009
Genre: Business & Economics
ISBN: 9241563893
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Makes the case for systems thinking in an easily accessible form for a broad interdisciplinary audience, including health system stewards, programme implementers, researchers, evaluators, and funding partners.

Social Aspects of Drug Discovery, Development and Commercialization

Social Aspects of Drug Discovery, Development and Commercialization
Author: Odilia Osakwe
Publisher: Academic Press
Total Pages: 326
Release: 2016-02-18
Genre: Medical
ISBN: 0128024976
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Social Aspects of Drug Discovery, Development and Commercialization provides an insightful analysis of the drug discovery and development landscape as it relates to society. This book examines the scientific, legal, philosophical, economic, political, ethical and cultural factors that contribute to drug development. The pharmaceutical industry is under scrutiny to develop safer and more effective drugs in a quicker and more affordable manner. Recent criticism and debates have emphasized varying opinions on the issues concerning the drug discovery and development process. This book provides thoughtful and valuable discussions and analysis of the social challenges and potential opportunities through all stages of the pharmaceutical process, from inception through marketing. With a unique focus on the social factors that increasingly play a role in how drug development is planned, structured, and executed throughout the drug product lifecycle, this is an essential resource for students, professors, and researchers who seek a better understanding of the interface between the pharmaceutical industry, health care systems, and society. Organized in a sequence of interrelated theories and principles that provide the foundation for increased understanding of the relevant social aspects Includes analysis of important new advances, key scientific and strategic issues, and overviews of recent progress in drug development Provides a global perspective with examples from developed areas, such as the US, Japan, Canada and Europe, as well as faster-growing and emerging economies including Brazil, Russia, India, and China Serves as an essential resource for students, professors, and researchers who seek a better understanding of the interface between the pharmaceutical industry, health care systems, and society

Managing the Drug Discovery Process

Managing the Drug Discovery Process
Author: Susan Miller
Publisher: Woodhead Publishing
Total Pages: 538
Release: 2016-11-08
Genre: Medical
ISBN: 0081006322
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Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and strategically manage the drug discovery process. This book takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but also how they can be overcome to ensure a robust pharmacoeconomic future. Written in an engaging manner and including memorable insights, this book is aimed at redirecting the drug discovery process to make it more efficient and cost-effective in order to achieve the goal of saving countless more lives through science. A valuable and compelling resource, this is a must-read for all students and researchers in academia and the pharmaceutical industry. Considers drug discovery in multiple R&D venues, including big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable

The Master Adaptive Learner

The Master Adaptive Learner
Author: William Cutrer
Publisher: Elsevier Health Sciences
Total Pages: 242
Release: 2019-09-29
Genre: Medical
ISBN: 032371112X
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Tomorrow’s best physicians will be those who continually learn, adjust, and innovate as new information and best practices evolve, reflecting adaptive expertise in response to practice challenges. As the first volume in the American Medical Association’s MedEd Innovation Series, The Master Adaptive Learner is an instructor-focused guide covering models for how to train and teach future clinicians who need to develop these adaptive skills and utilize them throughout their careers. Explains and clarifies the concept of a Master Adaptive Learner: a metacognitive approach to learning based on self-regulation that fosters the success and use of adaptive expertise in practice. Contains both theoretical and practical material for instructors and administrators, including guidance on how to implement a Master Adaptive Learner approach in today’s institutions. Gives instructors the tools needed to empower students to become efficient and successful adaptive learners. Helps medical faculty and instructors address gaps in physician training and prepare new doctors to practice effectively in 21st century healthcare systems. One of the American Medical Association Change MedEd initiatives and innovations, written and edited by members of the ACE (Accelerating Change in Medical Education) Consortium – a unique, innovative collaborative that allows for the sharing and dissemination of groundbreaking ideas and projects.

Complex Systems in Medicine

Complex Systems in Medicine
Author: David C. Aron
Publisher: Springer Nature
Total Pages: 255
Release: 2019-08-30
Genre: Medical
ISBN: 3030245934
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This unique title explores complex systems in clinical medicine and the subsequent implementation of that knowledge into practice. Written conversationally and as a reflection on the journey of learning about complex systems, the book explores how knowledge of these systems can be applied to four key roles in academic medicine: clinical practice, education, research, and administration. Further, this title emphasizes how gaining an understanding of complex systems can greatly help a physician deal with the many challenges found in academic medicine. Unlike other books on complexity in medicine, which tend to focus on only one aspect of the management of patients, Complex Systems in Medicine deals with the multifaceted roles of a physician. The approach in this book is uniquely qualitative rather than mathematical, and is written to make it not only of interest to physicians, trainees, and allied health providers, but also to make it more accessible to a non-medical audience. The inclusion of personal anecdotes by the author provides concrete examples of the application of knowledge of complex systems in academic medicine. A first-of-its-kind contribution to the literature, Complex Systems in Medicine: A Hedgehog’s Tale of Complexity in Clinical Practice, Research, Education, and Management is not only a novel reference for medical professionals, it is an accessible tool for the non-medical audience hoping to learn more about complex systems and their direct relevance to medicine, a field that deals with the infinite variety of humans and their ills. It illustrates the consequences of the interactive elements of patient care that make medicine both a science and an art.

Overcoming Obstacles in Drug Discovery and Development

Overcoming Obstacles in Drug Discovery and Development
Author: Kan He
Publisher: Elsevier
Total Pages: 448
Release: 2023-05-18
Genre: Medical
ISBN: 0128173394
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Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development. Provides real-world case studies in drug discovery and the development of drugs Illustrates the use of critical thinking and problem solving in approaching preclinical and clinical problems in drug discovery and development Illustrates and analyses examples of successes and failures in drug discovery and development that have not previously been reported

Health Design Thinking

Health Design Thinking
Author: Bon Ku
Publisher: MIT Press
Total Pages: 228
Release: 2020-03-17
Genre: Design
ISBN: 0262358913
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Applying the principles of human-centered design to real-world health care challenges, from drug packaging to early detection of breast cancer. This book makes a case for applying the principles of design thinking to real-world health care challenges. As health care systems around the globe struggle to expand access, improve outcomes, and control costs, Health Design Thinking offers a human-centered approach for designing health care products and services, with examples and case studies that range from drug packaging and exam rooms to internet-connected devices for early detection of breast cancer. Written by leaders in the field—Bon Ku, a physician and founder of the innovative Health Design Lab at Sidney Kimmel Medical College, and Ellen Lupton, an award-winning graphic designer and curator at Cooper Hewitt Smithsonian Design Museum—the book outlines the fundamentals of design thinking and highlights important products, prototypes, and research in health design. Health design thinking uses play and experimentation rather than a rigid methodology. It draws on interviews, observations, diagrams, storytelling, physical models, and role playing; design teams focus not on technology but on problems faced by patients and clinicians. The book's diverse case studies show health design thinking in action. These include the development of PillPack, which frames prescription drug delivery in terms of user experience design; a credit card–size device that allows patients to generate their own electrocardiograms; and improved emergency room signage. Drawings, photographs, storyboards, and other visualizations accompany the case studies. Copublished with Cooper Hewitt, Smithsonian Design Museum