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| Author | : Wei-Dong Zhang |
| Publisher | : Academic Press |
| Total Pages | : 380 |
| Release | : 2018-02-16 |
| Genre | : Medical |
| ISBN | : 0128127457 |
Download Systems Biology and Its Application in TCM Formulas Research Book in PDF, ePub and Kindle
Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment of cardiovascular diseases. The content combines theory and practice, and includes guidance for both theoretical concepts and operable technical routes. This is a valuable source not only for biomedical researchers involved in Systems Biology studies, but also for students and scientists interested in learning more about Traditional Chinese Medicine and its applications in contemporary medicine. Explains, in detail, the Shexiang Baoxin Pill (SBP), a TCM formula efficiently applied in the treatment of cardiovascular diseases Presents TCM formulas from perspectives of systems biology, basic chemical material groups, modern pharmacology and network biology Offers an overview on biology, modern chemistry and information technology as applied in Systems Biology research
| Author | : Guoan Luo |
| Publisher | : John Wiley & Sons |
| Total Pages | : 518 |
| Release | : 2012-05-11 |
| Genre | : Science |
| ISBN | : 1118313356 |
Download Systems Biology for Traditional Chinese Medicine Book in PDF, ePub and Kindle
The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.
| Author | : Guoan Luo |
| Publisher | : John Wiley & Sons |
| Total Pages | : 518 |
| Release | : 2012-07-03 |
| Genre | : Science |
| ISBN | : 0470637978 |
Download Systems Biology for Traditional Chinese Medicine Book in PDF, ePub and Kindle
The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.
| Author | : Saikat Gantait |
| Publisher | : Springer Nature |
| Total Pages | : 482 |
| Release | : 2021-11-13 |
| Genre | : Medical |
| ISBN | : 9811635293 |
Download Biotechnology of Anti-diabetic Medicinal Plants Book in PDF, ePub and Kindle
This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.
| Author | : Ram Sasisekharan |
| Publisher | : Springer |
| Total Pages | : 331 |
| Release | : 2019-04-23 |
| Genre | : Medical |
| ISBN | : 3030117510 |
Download The Science and Regulations of Naturally Derived Complex Drugs Book in PDF, ePub and Kindle
This volume in the AAPS Advances series covers various quality, safety and clinical aspects of drug development that are relevant to new and/or generic drugs containing a complex mixture of molecules. Specific topics discussed include: raw materials sourcing; manufacturing controls; characterization; identification of critical product quality components and attributes; identification of impurities, particularly as they bear on toxicity and immunogenicity; clinical trial study design considerations, and the regulatory science applications to development of such complex mixtures. Complex mixtures are challenging to characterize and analyze using standard methods. Further challenges extend throughout the product development cycle from raw material control to clinical study design. The regulatory landscape is rapidly changing as new types of complex mixtures are introduced into clinical trials and to the market (e.g., traditional Chinese medicines and medical marijuana products), while older products are facing generic competition for the first time (e.g., enoxaparin). The future outlook for complex generic drug products, as opposed to the more commonly developed targeted single agent drug products is not clear. The risks pertaining to lack of a full understanding of raw material control, process and controls in manufacture, as well as characterization of a complex mixture were seen vividly during the heparin crisis of 2008. As such powerful lessons have been learned about the regulatory science specific to complex products. The Science and Regulations of Naturally Derived Complex Drugs addresses the interests among industry, academics, and government on the issues surrounding the future development of mixtures for medicinal use.
| Author | : H.Gerhard Vogel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 576 |
| Release | : 2010-12-15 |
| Genre | : Medical |
| ISBN | : 3540898905 |
Download Drug Discovery and Evaluation: Methods in Clinical Pharmacology Book in PDF, ePub and Kindle
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
| Author | : Shao Li |
| Publisher | : Springer Nature |
| Total Pages | : 480 |
| Release | : 2021-09-29 |
| Genre | : Medical |
| ISBN | : 9811607532 |
Download Network Pharmacology Book in PDF, ePub and Kindle
This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
| Author | : Xian-Jun Fu |
| Publisher | : Frontiers Media SA |
| Total Pages | : 220 |
| Release | : 2023-06-05 |
| Genre | : Science |
| ISBN | : 2832525113 |
Download A new frontier for traditional medicine research - multi-omics approaches Book in PDF, ePub and Kindle
| Author | : Kang Ning |
| Publisher | : Springer Nature |
| Total Pages | : 144 |
| Release | : 2022-10-03 |
| Genre | : Medical |
| ISBN | : 9811947716 |
Download Traditional Chinese Medicine and Diseases Book in PDF, ePub and Kindle
This book focuses on the multi-omics big-data integration, the data-mining techniques and the cutting-edge omics researches in principles and applications for a deep understanding of Traditional Chinese Medicine (TCM) and diseases from the following aspects: (1) Basics about multi-omics data and analytical methods for TCM and diseases. (2) The needs of omics studies in TCM researches, and the basic background of omics research in TCM and disease. (3) Better understanding of the multi-omics big-data integration techniques. (4) Better understanding of the multi-omics big-data mining techniques, as well as with different applications, for most insights from these omics data for TCM and disease researches. (5) TCM preparation quality control for checking both prescribed and unexpected ingredients including biological and chemical ingredients. (6) TCM preparation source tracking. (7) TCM preparation network pharmacology analysis. (8) TCM analysis data resources, web services, and visualizations. (9) TCM geoherbalism examination and authentic TCM identification. Traditional Chinese Medicine has been in existence for several thousands of years, and only in recent tens of years have we realized that the researches on TCM could be profoundly boosted by the omics technologies. Devised as a book on TCM and disease researches in the omics age, this book has put the focus on data integration and data mining methods for multi-omics researches, which will be explained in detail and with supportive examples the “What”, “Why” and “How” of omics on TCM related researches. It is an attempt to bridge the gap between TCM related multi-omics big data, and the data-mining techniques, for best practice of contemporary bioinformatics and in-depth insights on the TCM related questions.
| Author | : Weici Tang |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1005 |
| Release | : 2013-06-29 |
| Genre | : Medical |
| ISBN | : 3642737390 |
Download Chinese Drugs of Plant Origin Book in PDF, ePub and Kindle
Traditional Chinese medicine has been used for thousands of years by a large population. It is currently still serving many of the health needs of the Chinese people; and still enjoying their confi dence it is practised in China in parallel with modern Western medical treatment. In addition to scientific organisations dedi cated to modern Western medicine, e. g. the Chinese Academy of Medical Sciences and various medical schools, a series of parallel institutions have been established in China to promote traditional Chinese medicine, such as the Academy of Traditional Chinese Medicine and training institutions. Almost all hospitals in China have a department of traditional medicine. Furthermore, a large number of scientific journals are dedicated to traditional Chinese medicine, covering both experimental and clinical investigations. Medicinal materials constitute a key topic in the treatment of disease according to traditional Chinese medicine. The Chinese Pharmacopoeia (1985 edition) is therefore divided into two sepa rate volumes, Volume I containing traditional Chinese medicinal materials and preparations and Volume II containing pharmaceu tics of Western medicine. The oldest Chinese review of medicinal materials, Shennong Bencao Jing (100-200 A. D. ), covered 365 herbal drugs. The clas sic compilation in this field, Bencao Gangmu (Compendium of Materia Medica), was published in 1578 by Li Shi-zhen and recorded as many as 1898 crude drugs of plant, animal and min eral origin.
