Synthetic Peptides And Peptidomimetics PDF Download
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Author | : Antonio Guarna |
Publisher | : John Wiley & Sons |
Total Pages | : 334 |
Release | : 2014-04-07 |
Genre | : Science |
ISBN | : 1119950600 |
Download Peptidomimetics in Organic and Medicinal Chemistry Book in PDF, ePub and Kindle
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Author | : Murray Goodman |
Publisher | : Thieme Medical Publishers |
Total Pages | : 785 |
Release | : 2004 |
Genre | : Medical |
ISBN | : 9781588903136 |
Download Synthesis of Peptides and Peptidomimetics Book in PDF, ePub and Kindle
It is now over 100 years since the first report of peptide synthesis by Emil Fischer in 1899. Houben-Weyl Synthesis of Peptides and Peptidomimetics, published in the English language, will reflect the current changes of this important discipline, which is at the center of modern chemistry and biology. The four-volume set, edited by the internationally renowned peptide chemists Professors Murray Goodman, Arthur Felix, Luis Moroder, and Claudio Toniolo will comprise a critical selection of synthetic methods in a consistent style. Synthesis of Peptides and Peptidomimetics is an indispensable resource for every synthetic chemist. For full information on the complete Houben-Weyl series, please visit the Houben-Weyl Homepage.
Author | : Sotirios Koutsopoulos |
Publisher | : Woodhead Publishing |
Total Pages | : 655 |
Release | : 2017-11-16 |
Genre | : Technology & Engineering |
ISBN | : 0081007426 |
Download Peptide Applications in Biomedicine, Biotechnology and Bioengineering Book in PDF, ePub and Kindle
Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides
Author | : Nir Qvit |
Publisher | : Academic Press |
Total Pages | : 792 |
Release | : 2022-09-22 |
Genre | : Science |
ISBN | : 0128204478 |
Download Peptide and Peptidomimetic Therapeutics Book in PDF, ePub and Kindle
Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development
Author | : Antonio Guarna |
Publisher | : John Wiley & Sons |
Total Pages | : 334 |
Release | : 2014-03-14 |
Genre | : Science |
ISBN | : 1118683145 |
Download Peptidomimetics in Organic and Medicinal Chemistry Book in PDF, ePub and Kindle
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Author | : Henry I. Mosberg |
Publisher | : MDPI |
Total Pages | : 406 |
Release | : 2020-03-13 |
Genre | : Medical |
ISBN | : 3039282883 |
Download Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery Book in PDF, ePub and Kindle
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.
Author | : Hirokazu Tamamura |
Publisher | : Springer |
Total Pages | : 113 |
Release | : 2018-01-16 |
Genre | : Science |
ISBN | : 981107691X |
Download Mid-size Drugs Based on Peptides and Peptidomimetics Book in PDF, ePub and Kindle
This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.
Author | : Alessandro Contini |
Publisher | : Frontiers Media SA |
Total Pages | : 145 |
Release | : 2019-09-26 |
Genre | : |
ISBN | : 2889630455 |
Download Folded Synthetic Peptides for Biomedical Applications Book in PDF, ePub and Kindle
Folded peptides - and peptide motifs within proteins - are abundant in living organisms, where they are essential for the biological activities of the peptides and proteins. During the past decades, much research has been dedicated to understanding the rules that govern peptide folding. Simultaneously, a range of strategies have been established for the conformational stabilization of bioactive peptides, as well as for the de novo design of peptides with defined secondary structures. These methods are either based on the chemical modification of the peptide backbone, such as cyclization and stapled peptides, or on the use of a range of non-proteinogenic amino acids that, in a defined sequential arrangement, induce secondary structures peptides. Such building blocks include D- and other non-proteinogenic amino acids, as well as beta- and gamma-amino acids. This Research Topic comprises a collection of papers by an international group of 77 scientists with a background in synthetic, analytical, computational and medicinal chemistry, as well as in biochemistry and pharmacology. Their research is presented here in a total of 11 papers (8 original research reports and 3 reviews), covering diverse aspects of folded synthetic peptides. These studies include the preparation and characterization of new peptide monomers with interesting folding properties, the synthesis and conformational analysis of non-natural peptides, as well as the use of folded peptidomimetics as molecular switches. Additionally, a range of biomedical applications, such as antimicrobial, anti-inflammatory, antiangiogenic and immune-stimulating activities, are also reported. We hope this eBook will be a source of inspiration and knowledge for scientist in various disciplines related to folded peptides and their many applications, as well as for those who want to learn more about this fascinating field of research.
Author | : Gregory Grant |
Publisher | : Oxford University Press |
Total Pages | : 404 |
Release | : 2002-04-04 |
Genre | : Science |
ISBN | : 9780198030430 |
Download Synthetic Peptides Book in PDF, ePub and Kindle
The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are often unfamiliar with not only the synthetic chemistry but also with important and useful aspects of design, analysis, handling, and applications. This volume is the second edition of a volume that was first published 10 years ago. It is written by experts in the field who provide detailed descriptions as well as practical advice for producing and using synthetic peptides. The various chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product, and the modern applications of synthetic peptides. This includes the basic principles of peptide structure, analysis and chain assembly as well as the latest in selective disulfide bond formation, new strategies for the production of large peptides, and sequencing peptides by mass spectrometry. This book was designed with the intent of providing useful information both for the novices to the field as well as more seasoned practitioners. Its contents will help prevent problems commonly encountered and allow scientists to optimize their use of synthetic peptides.
Author | : Jaya Varkey |
Publisher | : BoD – Books on Demand |
Total Pages | : 120 |
Release | : 2019-12-18 |
Genre | : Science |
ISBN | : 1839682574 |
Download Peptide Synthesis Book in PDF, ePub and Kindle
Peptide synthesis includes an array of techniques and procedures that enable the preparation of materials ranging from small peptides to large proteins. Many synthetic peptides have commercial and pharmaceutical applications, however, the synthesis of these peptides is a difficult task. This book addresses the common problems relating to the synthesis and applications of synthetic peptides. It discusses novel methods for the efficient synthesis of long chain and difficult peptide sequences and presents detailed analysis of various aspects of solid phase peptide synthesis. It also includes a section on antimicrobial peptides.