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| Author | : Gregory Grant |
| Publisher | : Oxford University Press |
| Total Pages | : 404 |
| Release | : 2002-04-04 |
| Genre | : Science |
| ISBN | : 9780198030430 |
Download Synthetic Peptides Book in PDF, ePub and Kindle
The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are often unfamiliar with not only the synthetic chemistry but also with important and useful aspects of design, analysis, handling, and applications. This volume is the second edition of a volume that was first published 10 years ago. It is written by experts in the field who provide detailed descriptions as well as practical advice for producing and using synthetic peptides. The various chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product, and the modern applications of synthetic peptides. This includes the basic principles of peptide structure, analysis and chain assembly as well as the latest in selective disulfide bond formation, new strategies for the production of large peptides, and sequencing peptides by mass spectrometry. This book was designed with the intent of providing useful information both for the novices to the field as well as more seasoned practitioners. Its contents will help prevent problems commonly encountered and allow scientists to optimize their use of synthetic peptides.
| Author | : Bernd Gutte |
| Publisher | : Elsevier |
| Total Pages | : 527 |
| Release | : 1995-10-24 |
| Genre | : Science |
| ISBN | : 0080538592 |
Download Peptides Book in PDF, ePub and Kindle
In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines
| Author | : Knud J. Jensen |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2016-08-27 |
| Genre | : Science |
| ISBN | : 9781493960040 |
Download Peptide Synthesis and Applications Book in PDF, ePub and Kindle
Peptides are used ubiquitously for studies in biology, biochemistry, chemical biology, peptide based medicinal chemistry, and many other areas of research. There is a number of marketed peptide drugs, and the prospects for the development of new peptide drugs are very encouraging. The second edition of Peptide Synthesis and Applications expands upon the previous editions with current, detailed methodologies for peptide synthesis. With new chapters on laboratory protocols for both the specialist and the non-specialist. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis and Application, Second Edition seeks to aid scientists in understanding different approaches to the synthesis of peptides by using a broad range of methods and strategies.
| Author | : Yi Yang |
| Publisher | : Academic Press |
| Total Pages | : 378 |
| Release | : 2015-09-01 |
| Genre | : Science |
| ISBN | : 0128011815 |
Download Side Reactions in Peptide Synthesis Book in PDF, ePub and Kindle
Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration
| Author | : Alessandro Contini |
| Publisher | : Frontiers Media SA |
| Total Pages | : 145 |
| Release | : 2019-09-26 |
| Genre | : |
| ISBN | : 2889630455 |
Download Folded Synthetic Peptides for Biomedical Applications Book in PDF, ePub and Kindle
Folded peptides - and peptide motifs within proteins - are abundant in living organisms, where they are essential for the biological activities of the peptides and proteins. During the past decades, much research has been dedicated to understanding the rules that govern peptide folding. Simultaneously, a range of strategies have been established for the conformational stabilization of bioactive peptides, as well as for the de novo design of peptides with defined secondary structures. These methods are either based on the chemical modification of the peptide backbone, such as cyclization and stapled peptides, or on the use of a range of non-proteinogenic amino acids that, in a defined sequential arrangement, induce secondary structures peptides. Such building blocks include D- and other non-proteinogenic amino acids, as well as beta- and gamma-amino acids. This Research Topic comprises a collection of papers by an international group of 77 scientists with a background in synthetic, analytical, computational and medicinal chemistry, as well as in biochemistry and pharmacology. Their research is presented here in a total of 11 papers (8 original research reports and 3 reviews), covering diverse aspects of folded synthetic peptides. These studies include the preparation and characterization of new peptide monomers with interesting folding properties, the synthesis and conformational analysis of non-natural peptides, as well as the use of folded peptidomimetics as molecular switches. Additionally, a range of biomedical applications, such as antimicrobial, anti-inflammatory, antiangiogenic and immune-stimulating activities, are also reported. We hope this eBook will be a source of inspiration and knowledge for scientist in various disciplines related to folded peptides and their many applications, as well as for those who want to learn more about this fascinating field of research.
| Author | : S. Muller |
| Publisher | : Elsevier |
| Total Pages | : 401 |
| Release | : 1999-11-25 |
| Genre | : Medical |
| ISBN | : 008085897X |
Download Synthetic Peptides as Antigens Book in PDF, ePub and Kindle
This newest edition to the Laboratory Techniques Series gives current state of the art use of synthetic peptides in molecular biology and practical protocols on how to conjugate peptides, immunize animals with peptides and monitor immune responses to peptides in vitro. It gives background information on antigenic specificity, prediction of antigenic sites in proteins and applications of peptides in immunology and virology, as probes in diagnosis and as vaccines. The book also describes antigenicity of proteins and methods to localize antigenic sites as well as methods for predicting epitoxes, and gives detailed protocols for peptide-carrier conjugation, immunization with peptides, and peptide immunoassays. The volume also describes typical use of antipeptide antibodies in molecular and cellular biology as well as the use of peptides in the diagnosis of viral infections and autoimmune diseases, and the use of peptides as potential synthetic vaccines. An excellent edition to an excellent series, available in hardbound and paperback.
| Author | : Paul Lloyd-Williams |
| Publisher | : CRC Press |
| Total Pages | : 306 |
| Release | : 1997-04-23 |
| Genre | : Medical |
| ISBN | : 9780849391422 |
Download Chemical Approaches to the Synthesis of Peptides and Proteins Book in PDF, ePub and Kindle
Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.
| Author | : N. Leo Benoiton |
| Publisher | : CRC Press |
| Total Pages | : 304 |
| Release | : 2016-04-19 |
| Genre | : Medical |
| ISBN | : 1420027697 |
Download Chemistry of Peptide Synthesis Book in PDF, ePub and Kindle
Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th
| Author | : Waleed M. Hussein |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2019-12-27 |
| Genre | : Science |
| ISBN | : 9781071602263 |
Download Peptide Synthesis Book in PDF, ePub and Kindle
This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis: Methods and Protocols serves as an essential guide to the many crucial processes that will allow researchers to efficiently prepare, purify, characterize, and use peptides for chemical, biochemical, and biological studies.
| Author | : Gregory A. Grant |
| Publisher | : W H Freeman & Company |
| Total Pages | : 382 |
| Release | : 1992 |
| Genre | : Science |
| ISBN | : 9780716770091 |
Download Synthetic Peptides Book in PDF, ePub and Kindle
Contemporary solid-phase peptide synthesis is a streamlined, automated technology and its products are more readily available to a larger group of researchers than ever before. But because many researchers rely on contract services to obtain their peptides, they are often not familiar with the "tricks of the trade" in artificial peptide design, manufacturing, and handling. This practical guide to the new peptide synthesis helps you to use artificial peptides more effectively, devise efficient experiments and avoid common pitfalls. The appendix lists sources offering custom peptide synthesis or other analytical services. Synthetic Peptides is the second volume in the UWBC Biotechnical Resource Series with Dr. Richard R. Burgess, Director of the University of Wisconsin Biotechnology Center, as Series Editor. The series is dedicated to providing practical guidance to researchers exploring new technologies and services.
