Synthesis Of Lactam Antibiotics PDF Download
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Author | : Alle Bruggink |
Publisher | : Springer Science & Business Media |
Total Pages | : 328 |
Release | : 2011-06-27 |
Genre | : Science |
ISBN | : 9401008507 |
Download Synthesis of β-Lactam Antibiotics Book in PDF, ePub and Kindle
Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Author | : M.I. Page |
Publisher | : Springer Science & Business Media |
Total Pages | : 368 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 9401129282 |
Download The Chemistry of β-Lactams Book in PDF, ePub and Kindle
It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH )=r)
Author | : Robert B. Morin |
Publisher | : |
Total Pages | : 430 |
Release | : 1982 |
Genre | : Antibiotics |
ISBN | : 9780125063029 |
Download Chemistry and Biology of [beta]-lactam Antibiotics Book in PDF, ePub and Kindle
Author | : Gunda I. Georg |
Publisher | : |
Total Pages | : 408 |
Release | : 1992 |
Genre | : Beta lactam antibiotics |
ISBN | : |
Download The Organic Chemistry of B [beta]-lactams Book in PDF, ePub and Kindle
Author | : Bimal K. Banik |
Publisher | : Springer |
Total Pages | : 419 |
Release | : 2017-05-11 |
Genre | : Science |
ISBN | : 3319556215 |
Download Beta-Lactams Book in PDF, ePub and Kindle
This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.
Author | : Gabor Lukacs |
Publisher | : Springer Science & Business Media |
Total Pages | : 808 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 3642756174 |
Download Recent Progress in the Chemical Synthesis of Antibiotics Book in PDF, ePub and Kindle
The use of antibiotics in the treatment by antibacterial and antifungal chemo therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.
Author | : Robert B. Morin |
Publisher | : Academic Press |
Total Pages | : 594 |
Release | : 2014-05-10 |
Genre | : Medical |
ISBN | : 1483277194 |
Download Penicillins and Cephalosporins Book in PDF, ePub and Kindle
Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
Author | : José-Luis Capelo-Martínez |
Publisher | : John Wiley & Sons |
Total Pages | : 730 |
Release | : 2019-09-24 |
Genre | : Medical |
ISBN | : 1119282527 |
Download Antibiotic Drug Resistance Book in PDF, ePub and Kindle
This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Author | : Robert B. Morin |
Publisher | : Elsevier |
Total Pages | : 441 |
Release | : 2014-05-10 |
Genre | : Medical |
ISBN | : 1483276694 |
Download The Biology of B-Lactam Antibiotics Book in PDF, ePub and Kindle
The Biology of ß-Lactam Antibiotics
Author | : Bimal K. Banik |
Publisher | : Springer |
Total Pages | : 386 |
Release | : 2010-06-01 |
Genre | : Science |
ISBN | : 3642128459 |
Download Heterocyclic Scaffolds I Book in PDF, ePub and Kindle
Contents: B. Alcaide ∙ P. Almendros: Novel Aspects on the Preparation of Spirocyclic and Fused Unsual β-Lactams.- S.S. Bari ∙ A. Bhalla: Spirocyclic β-Lactams: Synthesis and Biological Evaluation of Novel Heterocycles.- L. Troisi ∙ C. Granito ∙ E. Pindinelli: Novel and Recent Synthesis and Applications of β-Lactams.- C. Palomo ∙ M. Oiarbide: β-Lactams Ring Opening: A Useful Entry to Amino Acids and Relevant Nitrogen-Containing Compounds.- B. Mandal ∙ P. Ghosh ∙ B. Basu: Recent Approaches Towards Solid Phase Synthesis of β-Lactams.- A.Arrieta ∙ B. Lecea ∙ F.P. Cossio: Computational Studies on the Synthesis of β-Lactams Via [ 2+2] Thermal Cycloadditions.- B. K. Banik ∙ I. Banik ∙ F. F. Becker: Novel Anticancer β-Lactams